Research Summary

Selected Publications

• 1.Miyauchi.K, Sugimoto-Ishige, Ishige A. Harada, Y. Adachi, Y. Usami, Y. Kaji, T., Inoue, K., Hasegawa, H., Watanabe, T. Hijikata, A., Maemura, T.,Okada-Hatakeyame, M., Ohara, O., Kawaoka, Y., Takahashi, Y. Takemoir, T. Kubo, M.:
  “Protecitve neutralizing influenza antibody response in the subset of T follicular helper cells.”
  Nat. Immunol. 17, 1447-1458 (2016)
• 2.Kaji, T., Hijikata A., Ishige A., Kitami T., A., Watanabe T., Ohara, O., Shimoda, M., Okada, M., Taniguchi M., and Takemori, T.:
  “CD4 memory T cells develop and acquire functional competence by sequential cognate interactions and stepwise gene regulations.”
  Int. Immunol. 28, 267-282 (2016)
• 3.Nance, J.P., Belanger, S., Johnston, R.J., Hu J.K., Takemori, T. and Crotty, S.:
  “Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3.”
  Proc. Natl. Acad. Sci. USA 112, 13324-13329 (2015)
• 4.Nance, J.P., Belanger, S., Johnston, R.J., Takemori, T. and Crotty, S.:
  “Cutting Edge: T Follicular Helper Cell Differentiation Is Defective in the Absence of Bcl6 BTB Repressor Domain Function.”
  J. Immunol. 194: 5599-5603 (2015)
• 5.Takemori T.:
  “Generation of memory B cells.”
  pp227-230. In Molecular Biology of B cells. 2^nd edition. Edited by Alt, F., Honjo, T., Radbruch A. and Reth, M. Life Science Academic Press/ Elsevier. (2014)
• 6.Takemori, T., Kaji T, Takahashi T., Shimoda, M., and Rajewsky, K.:
  “Generation of memory B cells inside and outside the germinal center.”
  Eur. J. Immunol. 44:1258-1264 (2014)
• 7.Kaji, T., Furukawa, K., Ishige, A., Toyokura, I., Nomura, M., Okada, M., Takahashi, Y., Shimoda, M. and Takemori, T.:
  “Both mutated and unmutated memory B cells accumulate mutations and develop a new antibody repertoire optimally adapted to the secondary response.”
  Int. Immunol. 25(12):683-95 (2013)
• 8.Kometani K, Nakagawa R, Shinnakasu R, Kaji T, Rybouchkin A, Moriyama S, Furukawa K, Koseki H, Takemori T, Kurosaki T.:
  “Repression of the transcription factor Bach2 contributes to predisposition of IgG1 memory B cells toward plasma cell differentiation.”
  Immunity. 13:1074-7613 (2013)
• 9.Ato, A., Takahashi, Y., Fujii H., Hashimoto, S.-I., Kaji, T., Yamamoto, K., Itamura, S., Horiuchi, Y., Arakawa, Y., Tashiro, M., Takemori, T.:
  “Influenza A whole virion vaccine induces a rapid reduction of peripheral blood leukocytes via interferon-α-dependent apoptosis.”
  Vaccine, 31:2184-2190 (2013)
• 10.Kaji T, Ishige A, Hikida M, Taka J, Hijikata A, Kubo A, Nagashima T, Takahashi Y, Okada M, Kurosaki, T., Ohara O, Rajewsky K and Takemori T.:
  “Distinct cellular pathways select germ-line encoded and somatically mutated antibodies into immunological memory.”
  J. Exp. Med. 209:2079-2097 (2012)

Lab Members

Contact Information