RIKEN Center for Integrative Medical Sciences Laboratory for Genomics of Diabetes and Metabolism
Team Leader: Momoko Horikoshi (M.D., Ph.D)
The prevalence of life-style related diseases, such as diabetes mellitus, is progressively increasing worldwide including Japan. Patients with diabetes may develop micro- and/or macro-vascular complications if they are not treated properly, and will face deterioration of prognosis and quality of life. The pathogenesis of the disease is multi-factorial, and genetic susceptibility is considered as an important factor for the development and progression of diabetes. By using genome-wide genetic data, our laboratory aims to identify genetic regions associated with diabetes to better understand the mechanism through which the disease develops, and translate the information into clinical practice.
Main Research Fields
- Medicine, Dentistry & Pharmacy
- Genomic Medicine
- Early growth
Papers with an asterisk(*) are based on research conducted outside of RIKEN.
- 1.*Horikoshi M, Beaumont RN, Day FR, et al:
Genome-wide associations for birth weight and correlations with adult disease.
Nature 538(7624):248-252 (2016).
- 2.*Horikoshi M, Pasquali L, Wiltshire S, et al:
Trans-ethnic fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.
Hum Mol Genet 25(10):2070-2081 (2016).
- 3.*Horikoshi M, Mӓgi R, van de Bunt M, et al:
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.
PLoS Genet 11(7):e1005230 (2015).
- 4.*Surakka I, Horikoshi M, Mägi R, et al:
The impact of low-frequency and rare variants on lipid levels.
Nat Genet 47(6):589-97 (2015).
- 5.*Horikoshi M, Yaghootkar H, Mook-Kanamori DO, et al:
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Nat Genet 45(1):76-82 (2013).
- 6.*Kodama K, Horikoshi M, Toda K, et al:
Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes.
Proc Natl Acad Sci USA 109(18):7049-54 (2012).
- 7.*Horikoshi M, Hara K, Ito C, et al:
Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.
Diabetologia 50(12):2461-6 (2007).
- 8.*Horikoshi M, Hara K, Ito C, et al:
A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.
Diabetologia 50(4):747-51 (2007).
- Momoko Horikoshi
- Team Leader
- Makiko Taira
- Postdoctoral Researcher
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
Email: momoko.horikoshi [at] riken.jp