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RIKEN Center for Integrative Medical Sciences Laboratory for Inflammatory Regulation

Team Leader: Takashi Tanaka (M.D., Ph.D)

Research Summary

Takashi  Tanaka(M.D., Ph.D)

Inflammation is an important host defense mechanism to fight against invading microbial pathogens. Inflammatory responses should be tightly regulated, otherwise, an excess of these responses can damage normal tissue and may cause autoimmune or allergic diseases. Our research goal is to identify key regulators of inflammation-related signal transduction pathways, and to clarify the molecular mechanisms for regulating inflammatory responses. These studies should contribute to the development of new therapeutic tools to control the exaggerated inflammation seen in certain human diseases. We now focus on the analysis of LIM proteins that negatively regulate inflammatory responses.

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Biology


  • Inflammatory Regulation
  • Autoimmune Diseases
  • Transcriptional regulation
  • Ubiquitonn E3 ligase
  • LIM protein family

Selected Publications

  • 1.Shin, C., Ito, Y., Ichikawa, S., Tokunaga, M., Sataka-Sogawa, K., Tanaka ,T.;
    “MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-kB and negatively regulates inflammatory responses”
    Sci. Rep. 7, 46097 (2017)
  • 2.Ono, R., Kaisho, T., Tanaka, T.:
    “PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm”
    Sci. Rep. 5, 18327 (2015)
  • 3.Tanaka, T., Shibazki, A., Ono, R., Kaisho, T.:
    “HSP70 mediates degradation of the p65 subunit ofnuclear factor κB to inhibit inflammatory signaling”
    Sci. Signal. 7(356), ra119 (2014)
  • 4.Tanaka, T., Yamamoto, Y., Muromoto, R., Ikeda, O., Sekine, Y., Grusby, M.J., Kaisho, T., Matsuda, T.:
    “PDLIM2 inhibits T Helper 17 cell development and granulomatous inflammation through degradation of STAT3.”
    Sci. Signal. 4(202), ra85 (2011)
  • 5.Kaisho, T. and Tanaka, T.:
    “Turning NF-κB and IRFs on and off in DCs.”
    Trends Immunol., 29, 329-336 (2008)
  • 6.Tanaka, T. Grusby, M.J. and Kaisho, T.:
    “PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunit.”
    Nat. Immunol. 8, 584-591 (2007)
  • 7.Nakahira, M., Tanaka, T., Robson, B.E., Mizgerd, J.P. and Grusby, M.J.:
    “Regulation of Signal Transducer and Activator of Transcription Signaling by the Tyrosine Phosphatase PTP-BL.”
    Immunity 26, 163-176 (2007)
  • 8.Tanaka, T., Soriano, M.A. and Grusby, M.J.:
    “SLIM is a nuclear ubiquitin ligase that negatively regulates STAT signaling.”
    Immunity, 22, 729-736 (2005)

Related Links

Lab Members

Principal investigator

Takashi Tanaka
Team Leader

Core members

Asuka Onuma
Postdoctoral Researcher
Aya Jodo
Technical Staff I
Akiko Sugimoto
Technical Staff I

Contact Information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9283
Fax: +81-(0)45-503-7064
Email: takashi.tanaka [at] riken.jp