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Medical Sciences Innovation Hub Program Cancer Immunology Data Multi-level Integration Unit

Unit Leader: Kazuhiro Kakimi (M.D., Ph.D.)

Research Summary

Kazuhiro  Kakimi(M.D., Ph.D.)

The activities of my laboratory are directed at understanding the dynamics of the anti-tumor immune response in vivo at the molecular, cellular and organismal levels and to develop more effective immunotherapy against cancer. I perform both clinical immunology in humans and basic preclinical immunology using animal models. I especially focus on the spatiotemporal analysis of anti-tumor immunity in both humans and experimental animals. Tumor-specific immunity is evaluated using standardized immunological assays and molecular analysis with NGS technology. By integrating all the information in each individual patient, comprehensive immunomonitoring can be performed and the most appropriate cancertherapy can be provided to patients in the future.

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Biological Sciences
  • Biology
  • Tumor diagnostics
  • Immunology
  • Oncology medicine

Keywords

  • Tumor Immunology
  • Immune regulation
  • Immunotherapy
  • Biomarker
  • Neoantigen

Selected Publications

  • 1.Nagaoka K, Hosoi A, Iino T, Morishita Y, Matsushita H, Kakimi K.:
    “Dendritic cell vaccine induces antigen-specific CD8(+) T cells that are metabolically distinct from those of peptide vaccine and is well-combined with PD-1 checkpoint blockade.”
    Oncoimmunology 7, e1395124 (2017)
  • 2.Hosoi A, Takeda K, Nagaoka K, Iino T, Matsushita H, Ueha S, Aoki S, Matsushima K, Kubo M, Morikawa T, Kitaura K, Suzuki R, Kakimi K.:
    “Increased diversity with reduced "diversity evenness" of tumor infiltrating T-cells for the successful cancer immunotherapy.”
    Sci Rep. 8, 1058 (2018)
  • 3.Matsushita H, Hasegawa K, Oda K, Yamamoto S, Nishijima A, Imai Y, Asada K, Ikeda Y, Karasaki T, Fujiwara K, Aburatani H, Kakimi K.:
    “The frequency of neoantigens per somatic mutation rather than overall mutational load or number of predicted neoantigens per se is a prognostic factor in ovarian clear cell carcinoma.”
    Oncoimmunology 6, e1338996 (2017)
  • 4.Karasaki T, Nagayama K, Kuwano H, Nitadori JI, Sato M, Anraku M, Hosoi A, Matsushita H, Morishita Y, Kashiwabara K, Takazawa M, Ohara O, Kakimi K, Nakajima J.:
    “An Immunogram for the Cancer-Immunity Cycle: Towards Personalized Immunotherapy of Lung Cancer.”
    J Thorac Oncol. 12, 791-803 (2017)
  • 5.Karasaki T, Nagayama K, Kuwano H, Nitadori JI, Sato M, Anraku M, Hosoi A, Matsushita H, Takazawa M, Ohara O, Nakajima J, Kakimi K.:
    “Prediction and prioritization of neoantigens: integration of RNA sequencing data with whole-exome sequencing.”
    Cancer Sci. 108, 170-177 (2017)
  • 6.Matsushita H, Sato Y, Karasaki T, Nakagawa T, Kume H, Ogawa S, Homma Y, Kakimi K.:
    “Neoantigen Load, Antigen Presentation Machinery, and Immune Signatures Determine Prognosis in Clear Cell Renal Cell Carcinoma.“
    Cancer Immunol Res. 4, 463-71 (2016)
  • 7.Karasaki T, Nagayama K, Kawashima M, Hiyama N, Murayama T, Kuwano H, Nitadori J, Anraku M, Sato M, Miyai M, Hosoi A, Matsushita H, Kikugawa S, Matoba R, Ohara O, Kakimi K, Nakajima J.:
    “Identification of Individual Cancer-Specific Somatic Mutations for Neoantigen-Based Immunotherapy of Lung Cancer.”
    J Thorac Oncol 11, 324-33 (2016)
  • 8.Kurose K, Ohue Y, Wada H, Iida S, Ishida T, Kojima T, Doi T, Suzuki S, Isobe M, Funakoshi T, Kakimi K, Nishikawa H, Udono H, Oka M, Ueda R, Nakayama E.:
    “Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients.”
    Clin Cancer Res. 21, 4327-36 (2015)
  • 9.Matsushita H, Enomoto Y, Kume H, Nakagawa T, Fukuhara H, Suzuki M, Fujimura T, Homma Y, Kakimi K.:
    “A pilot study of autologous tumor lysate-loaded dendritic cell vaccination combined with sunitinib for metastatic renal cell carcinoma.”
    J Immunother Cancer. 2, 30 (2014)
  • 10.Matsushita H, Hosoi A, Ueha S, Abe J, Fujieda N, Tomura M, Maekawa R, Matsushima K, Ohara O, Kakimi K.:
    “Cytotoxic T lymphocytes block tumor growth both by lytic activity and IFNγ-dependent cell-cycle arrest.”
    Cancer Immunol Res 3, 26-36 (2015)

Related Links

Lab Members

Principal investigator

Kazuhiro Kakimi
Unit Leader

Contact Information

Nihonbashi 1-chome Mitsui Building, 15th floor
1-4-1 Nihonbashi Chuo-ku, Tokyo
103-0027, Japan
Tel: +81-(0)3-6225-2246

Email: kazuhiro.kakimi [at] riken.jp

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