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Medical Sciences Innovation Hub Program Developmental Disorder Data Multi-level Integration Unit

Unit Leader: Kazuhiro Sakurada (Ph.D.)

Research Summary

Kazuhiro  Sakurada(Ph.D.)

Abnormal rhythms of various biological functions are observed in Autism spectrum disorders (ASD) patients. Current evidences suggest that disturbance of the development and cooperation of rhythms of biological functions in fetuses may be related to maternal sleep disorder, and low nutritional status including vitamin D during pregnancy. Then, we will systematically approach developing mechanisms of the rhythms of biological functions even at a fetus stage and during an infant stage by analyzing in an integrated manner both medical and non-medical data such as physiological data from blood analysis or wearable devices, life-style surveys, behavior observation, etc.

This Unit was built by Yukuo KONISHI and has been led by Sakurada since September, 2019.

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Complex Systems


  • Pediatrics
  • Developmental neurology
  • Developmental disorders

Selected Publications

  • 1.*Tanaka M, Tajima S, Mizuno K, Ishii A, Konishi Y, Miike T,and Watanabe Y.:
    "Frontier studies on fatigue,autonomic nerve dysfunction,and sleep-rhythm disorder."
    The Journal of Physiological Sciences 65. 483-498 (2015).
  • 2.*Kanemaru N, Watanabe H, Kihara H, Nakano H, Nakamura T, Nakano J, Taga G, and Konishi Y.:
    "Jerky spontaneous movements at term age in preterm infants who later developed cerebral palsy. "
    Early Human Development 90. 387-392 (2014).
  • 3.*Kanemaru N, Watanabe H, Kihara H, Nakano H, Takaya R, Nakamura T, Nakano J, Taga G, and Konishi Y.:
    "Specific characteristics of spontaneous movements in preterm infants at term age sre associated with developmental delays at age 3 years."
    Developmental Medicine & Child Neurology 55. 713-721 (2013).
  • 4.*Yukihiko Konishi , Kensuke Okubo, Ikuko Kato, Sonoko Ijichi, Tomoko Nishida, Takashi Kusaka, Kenichi Isobe, Susumu Itoh, Masaharu Kato, and Yukuo Konishi.:
    "A developmental change of the visual behavior of the face recognition in the early infancy."
    Brain & Development 34. 719-722 (2012).
  • 5.*Sato H, Hirabayashi Y, Tsubokura H, Kanai M, Ashida T, Konishi I, Uchida-Ota M, Konishi Y, and Maki A.:
    "Cerebral Hemodynamics in Newborn Infants Exposed to Speech Sounds: A Whole-Head Optical Topography Study."
    Human Brain Mapping 33. 2092-2103 (2011).
  • 6.*Homae F, Watanabe H, Otobe T, Nakano T, Go T, Konishi Y and Taga G.:
    "Development of Global Cortical Networks in Early Infancy."
    The Journal of Neuroscience 30. 4877-4882 (2010).
  • 7.*Kato M, Konishi Y.:
    "Auditory dominance in the error correction process:A synchronized tapping study."
    Brain Research 1084. 115-122 (2006).
  • 8.*Taga G, Asakawa K, Maki A,, Konishi Y, and Koizumi H.:
    "Brain imaging in awake infants by near-infrared optical topography."
    PNAS 100. 10722-10727 (2003).

Related Links

Lab Members

Principal investigator

Kazuhiro Sakurada
Unit Leader

Contact Information

Nihonbashi 1-chome Mitsui Building, 15th floor
1-4-1 Nihonbashi Chuo-ku, Tokyo
103-0027, Japan
Tel: +81-(0)3-6225-2246
Email: yukuo.konishi [at] riken.jp