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  5. Beam Mutagenesis Group

RIKEN Nishina Center for Accelerator-Based Science Plant Genome Evolution Research Team

Team Leader: Tomoko Abe (D.Agr.)

Research Summary

Whole genome analyses have become familiar along with innovations in the field of molecular biology. We have been using high-throughput DNA sequencing techniques such as next-generation sequence instruments to analyze gene mutations. LETmax mutants have become more and more useful and important in modern genetic studies, enabling the discovery of genes that control important traits, and revealing the functions and mechanisms underlying their operation. The discovery of genes using mutants may lead to emergence of a new field in biology, “mutagenomics”.

Main Research Fields

  • Biology

Related Research Fields

  • Complex Systems
  • Interdisciplinary Science & Engineering
  • Biological Sciences
  • Agricultural Sciences

Selected Publications

  • 1.Kazama Y., Ishii K., Hirano T., Wakana T., Yamada M., Ohbu S., and Abe T.:
    “Different mutational function of low- and high-linear energy transfer heavy-ion irradiation demonstrated by whole genome re-sequencing of Arabidopsis mutants”
    Plant J. 92, 1020-1030 (2017)
  • 2.Ishii K., Kazama Y., Hirano T., Hamada M., Ono Y., Yamada M., and Abe T.:
    “AMAP: A pipeline for whole-genome mutation detection in Arabidopsis thaliana”
    Genes Genet. Syst. 91, 229-233 (2016)
  • 3.Kazama Y., Ishii K., Aonuma W., Ikeda T., Kawamoto H., Koizumi A., Filatov D.A., Chibalina M., Bergero R., Charlesworth D., Abe T., and Kawano S.:
    “A new physical mapping approach refines the sex-determining gene positions on the Silene latifolia Y-chromosome”
    Sci. Rep. 6,18917 (2016)
  • 4.Katano M., Takahashi K., Hirano T., Kazama Y., Abe T., Tsukaya H., and Ferjani A.:
    “Suppressor screen and phenotype analyses revealed an emerging role of the monofunctional peroxisomal enoyl-CoA hydratase 2 in compensated cell enlargement”
    Front. Plant. Sci. 7, 132 (2016)
  • 5.Yamada K, Suzuki H, Takeuchi T, Kazama Y, Mitra S, Abe T, Goda K, Suzuki K, and Iwata O.:
    “Efficient selective breeding of live oil-rich Euglena gracilis with fluorescence-activated cell sorting”
    Sci. Rep. 6, 26327 (2016)
  • 6.Hirano T., Kazama Y., Ishii K., Ohbu S., Shirakawa Y., and Abe T.:
    “Comprehensive identification of mutations induced by heavy‐ion beam irradiation in Arabidopsis thaliana”
    Plant J. 82, 93–104 (2015)
  • 7.Kazama Y., Fujiwara M.T., Takehisa H., Ohbu S., Saito H., Ichida H., Hayashi Y., and Abe T.:
    “Characterization of a heavy-ion induced white flower mutant of allotetraploid Nicotiana tabacum”
    Plant Cell Rep. 32, 11–19 (2013).
  • 8.Kazama Y., Nishihara K., Bergero R., Fujiwara M.T., Abe T., Charlesworth D., and Kawano S.:
    “SlWUS1; An X-linked Gene Having No Homologous Y-Linked Copy in Silene latifolia”
    G3 2, 1269-1278 (2012)
  • 9.Kazama Y., Hirano T., Saito H., Liu Y., Ohbu S., Hayashi Y., and Abe T.:
    “Characterization of highly efficient heavy-ion mutagenesis in Arabidopsis thaliana”
    BMC Plant Biol. 11, 161 (2011).
  • 10.Kazama Y., Fujiwara M.T., Koizumi A., Nishihara K., Nishiyama R., Kifune E., Abe T., and Kawano S.:
    “A SUPERMAN-like gene is exclusively expressed in female flowers of the dioecious plant Silene latifolia” Plant Cell Physiol. 50, 1127-1141(2009).

Related Links

Lab Members

Principal investigator

Tomoko Abe
Team Leader

Core members

Kotaro Ishii
Contract Researcher

Contact Information

Bioscience Building
2-1 Hirosawa, Wako, Saitama 351-0198, Japan