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RIKEN SPring-8 Center Advanced NMR Technology Development Team

Team Leader: Toshio Yamazaki (Ph.D.)

Research Summary

Toshio  Yamazaki(Ph.D.)

We are developing experimental technology and equipment of nuclear magnetic resonance (NMR) spectroscopy. High-temperature superconductor makes ultrahigh magnetic field, which brings about high sensitivity and high resolution. We enhance performance of spectrometer for the higher field and the higher frequencies. There are more benefits from high field. By using field-depended sharpening and relaxation of NMR signals, the motion of molecules can be detected more clearly. Moreover, we use enhanced alignment and relaxation and control them to pursue new experimental methods. We also develop new high-sensitive probes for variety of samples and conditions.

Main Research Fields

  • Interdisciplinary Science & Engineering

Related Research Fields

  • Chemistry
  • Engineering
  • Biological Sciences
  • Applied chemistry
  • Electrical and electronic engineering

Keywords

  • Nuclear Magnetic Resonance
  • Photoisomerization
  • Protein Folding

Selected Publications

  • 1.Nagashima, T., Ueda, K., Nishimura, C., Yamazaki, T.:
    "Structure-Correlation NMR spectroscopy for Macromolecules Using Repeated Bidirectional Photoisomerization of Azobenzene"
    Anal. Chem. 87, 11544-11552 (2015)
  • 2.Shi, X., Prasanna, C., Nagashima, T., Yamazaki, T., Pervushin, K., NOrdenskiold, L.:
    "Structure and Dynamics in the Nucleosome Revealed by Solid-State NMR"
    Angew. Chem. Int. Ed. Engl. 57 9734-9738 (2018)
  • 3.Yanaka, S., Yamazaki, T., Yogo, R., Noda, M., Uchiyama, S., Yagi, H., Kato, K.:
    "NMR Detection of Semi-Specific Antibody Interactions in Serum Envirionments"
    Molecules 22, 1619 (2017)
  • 4.Anandalakshmi, V., Murugan, E., Leng, EGT., Ting, LW., Chaurasia SS, Yamazaki, T., Nagashima, T., George BL, Peh, GSL, Pervushi, K., Lakshminarayanan, R., Mehta, JS.:
    "Effect of position-specific single-point mutations and biophysical characterization of amyloidogenic peptide fragments identified from lattice corneal dystrophy patients"
    Biochem J. 474 1705-1725 (2017)
  • 5.Hashi, K., Ohki, S., Matasumoto, S., Nishijima, G., Goto, A., Deguchi, K., Yamada, K., Noguchi, T., Sakai, S., Takahashi, M., Yanagisawa, Y., Iguchi, S., Yamazaki, T., Naeda, H., Tanamka, R., Beniti, T., Suematsu, H., Miki, T., Saito, K., Shimizu, T.:
    "Achievement of 1020 MHz NMR"
    J. Magn. Reson. 256, 30-33 (2015)
  • 6.Hashi, K., Deguchi, K., Yamazaki, T., Ohki, S., Matsumoto, S., Nishijima, G., Goto, A., Yamada, K., Noguchi, T., Sakai, S., Takahashi, M., Yanagisawa, Y., Iguchi, S., Maeda, H., Tanaka, R., Nemoto, T., Suematsu, H., To, J., Torres, J., Pervushin, K., Shimizu, T.:
    "Efficiency of High Magnetic Fields in Solid-state NMR"
    Chemistry Letters 45, 209-210 (2016)

Related Links

Lab Members

Principal investigator

Toshio Yamazaki
Team Leader

Core members

Masato Takahashi
Senior Scientist
Yoshinori Yanagisawa
Senior Scientist
Renzhong Piao
Postdoctoral Researcher
Tatsuya Matsunaga
Postdoctoral Researcher

Contact Information

West NMR Complex N108,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9262
Fax: +81-(0)45-503-9641
Email: toshio.yamazaki [at] riken.jp

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