RIKEN SPring-8 Center Advanced NMR Technology Development Team
Team Leader: Toshio Yamazaki (Ph.D.)
Research Summary

We are developing experimental technology and equipment of nuclear magnetic resonance (NMR) spectroscopy. High-temperature superconductor makes ultrahigh magnetic field, which brings about high sensitivity and high resolution. We enhance performance of spectrometer for the higher field and the higher frequencies. There are more benefits from high field. By using field-depended sharpening and relaxation of NMR signals, the motion of molecules can be detected more clearly. Moreover, we use enhanced alignment and relaxation and control them to pursue new experimental methods. We also develop new high-sensitive probes for variety of samples and conditions.
Main Research Fields
- Interdisciplinary Science & Engineering
Related Research Fields
- Chemistry
- Engineering
- Biological Sciences
- Applied chemistry
- Electrical and electronic engineering
Keywords
- Nuclear Magnetic Resonance
- Photoisomerization
- Protein Folding
Selected Publications
- 1.Nagashima, T., Ueda, K., Nishimura, C., Yamazaki, T.:
"Structure-Correlation NMR spectroscopy for Macromolecules Using Repeated Bidirectional Photoisomerization of Azobenzene"
Anal. Chem. 87, 11544-11552 (2015) - 2.Shi, X., Prasanna, C., Nagashima, T., Yamazaki, T., Pervushin, K., NOrdenskiold, L.:
"Structure and Dynamics in the Nucleosome Revealed by Solid-State NMR"
Angew. Chem. Int. Ed. Engl. 57 9734-9738 (2018) - 3.Yanaka, S., Yamazaki, T., Yogo, R., Noda, M., Uchiyama, S., Yagi, H., Kato, K.:
"NMR Detection of Semi-Specific Antibody Interactions in Serum Envirionments"
Molecules 22, 1619 (2017) - 4.Anandalakshmi, V., Murugan, E., Leng, EGT., Ting, LW., Chaurasia SS, Yamazaki, T., Nagashima, T., George BL, Peh, GSL, Pervushi, K., Lakshminarayanan, R., Mehta, JS.:
"Effect of position-specific single-point mutations and biophysical characterization of amyloidogenic peptide fragments identified from lattice corneal dystrophy patients"
Biochem J. 474 1705-1725 (2017) - 5.Hashi, K., Ohki, S., Matasumoto, S., Nishijima, G., Goto, A., Deguchi, K., Yamada, K., Noguchi, T., Sakai, S., Takahashi, M., Yanagisawa, Y., Iguchi, S., Yamazaki, T., Naeda, H., Tanamka, R., Beniti, T., Suematsu, H., Miki, T., Saito, K., Shimizu, T.:
"Achievement of 1020 MHz NMR"
J. Magn. Reson. 256, 30-33 (2015) - 6.Hashi, K., Deguchi, K., Yamazaki, T., Ohki, S., Matsumoto, S., Nishijima, G., Goto, A., Yamada, K., Noguchi, T., Sakai, S., Takahashi, M., Yanagisawa, Y., Iguchi, S., Maeda, H., Tanaka, R., Nemoto, T., Suematsu, H., To, J., Torres, J., Pervushin, K., Shimizu, T.:
"Efficiency of High Magnetic Fields in Solid-state NMR"
Chemistry Letters 45, 209-210 (2016)
Related Links
Lab Members
Principal investigator
- Toshio Yamazaki
- Team Leader
Core members
- Masato Takahashi
- Senior Scientist
- Yoshinori Yanagisawa
- Senior Scientist
- Renzhong Piao
- Postdoctoral Researcher
- Tatsuya Matsunaga
- Postdoctoral Researcher
Contact Information
West NMR Complex N108,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9262
Fax: +81-(0)45-503-9641
Email: toshio.yamazaki [at] riken.jp