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RIKEN SPring-8 Center SACLA Science Research Group

Group Director: So Iwata (Ph.D.)

Research Summary

So  Iwata(Ph.D.)

SACLA produces X-ray pulses billion times brighter than synchrotron radiation sources. SACLA has a potential to change life-science, particular structural biology, revolutionary. The user operation of SACLA has started and now it's critical to develop data collection systems focusing on specific scientific areas. Recently, we are developing a data collection system focusing on dynamic crystallography putting a particular effort on membrane proteins. An experimental system for pump-probe experiments based on serial femtosecond crystallography using a viscous material injector has been developed to visualize conformational changes in bacteriorhodopsin (bR) from nanoseconds to milliseconds following photoactivation.

Main Research Fields

  • Biology

Related Research Fields

  • Medicine, Dentistry & Pharmacy
  • Biological Science

Keywords

  • X-ray Free Electron Laser
  • Serial Femtosecond Crystallography
  • Membrane Protein
  • Protein Dynamics
  • Technical Development in Life-Science

Selected Publications

  • 1.Nango E, Royant A, Kubo M, Nakane T, Wickstrand C, Kimura T, Tanaka T, Tono K, Song C, Tanaka R, Arima T, Yamashita A, Kobayashi J, Hosaka T, Mizohata E, Nogly P, Sugahara M, Nam D, Nomura T, Shimamura T, Im D, Fujiwara T, Yamanaka Y, Jeon B, Nishizawa T, Oda K, Fukuda M, Andersson R, Båth P, Dods R, Davidsson J, Matsuoka S, Kawatake S, Murata M, Nureki O, Owada S, Kameshima T, Hatsui T, Joti Y, Schertler G, Yabashi M, Bondar AN, Standfuss J, Neutze R*, and Iwata S*.:
    "A three-dimensional movie of structural changes in bacteriorhodopsin"
    Science 354(6319), 1552-1557 (2016)

Recent Research Results

Publications

Related Links

Lab Members

Principal investigator

So Iwata
Group Director

Contact Information

1-1-1 Kouto, Sayo-cho
Sayo-gun, Hyogo
679-5148 Japan

Email: s.iwata [at] spring8.or.jp

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