研究概要

主要論文

• 1. Takatani S., Tahara T., Tsuji E., et al.:
  "Synthesis of L-[5-¹¹C]Leucine and L-α-[5-¹¹C]Methylleucine via Pd⁰-mediated ¹¹C-Methylatn and Microfluidic Hydrogenation: Potentiality of Leucine PET Probes for Tumor Imaging"
  ChemMedChem, 2021, in press. doi: 10.1002/cmdc.202100255
• 2. Doi H., Goto M., Sato.Y.:
  "Pd0-Mediated Cross-Coupling of [11C]Methyl Iodide with Carboxysilane for Synthesis of [11C]Acetic Acid and Its Active Esters: 11C-Acetylation of Small, Medium, and Large Molecules"
  Eur. J. Org. Chem., 3970–3979, (2021). doi: 10.1002/ejoc.202100638
• 3. Goto M., Nishiyama A., Yamaguchi T., et al.:
  "Synthesis of ¹¹C-labeled ubiquinone and ubiquinol via Pd⁰-mediated rapid C-[¹¹C]methylation using [¹¹C]methyl iodide and 39-demethyl-39-(pinacolboryl)ubiquinone."
  Journal of Labelled Compounds and Radiopharmaceuticals 62. 86–94 (2019) doi: 10.1002/jlcr.3700
• 4. Doi H., Kida T., Nishino K., et al.:
  "Blood-Brain Barrier Permeability of Ginkgolide: Comparison of the Behavior of PET Probes 7α-{ ¹⁸ F]Fluoro- and 10-O -p -[¹¹C]Methylbenzyl Ginkgolide B in Monkey and Rat Brains"
  The Journal of Organic Chemistry 80(12). 6250-6258 (2015) doi: 10.1021/acs.joc.5b00685
• 5. Doi H., Sato K., Shindou H., et al.:
  "Blood-Brain Barrier Permeability of Ginkgolide: Comparison of the Behavior of PET Probes 7α-{ ¹⁸ F]Fluoro- and 10-O -p -[¹¹C]Methylbenzyl Ginkgolide B in Monkey and Rat Brains"
  Bioorganic & Medicinal Chemistry 24. 5148–5157 (2016) doi: 10.1016/j.bmc.2016.08.032
• 6. Doi H., Mawatari A., Kanazawa M., et al.:
  "Synthesis of ¹¹C-Labeled Thiamine and Fursultiamine for in Vivo Molecular Imaging of Vitamin B₁ and Its Prodrug Using Positron Emission Tomography."
  The Journal of Organic Chemistry 80(12). 6250-6258 (2015) doi: 10.1021/acs.joc.5b00685
• 7. Doi H.:
  "Pd-mediated rapid cross-couplings using [¹¹C]methyl iodide: groundbreaking labeling methods in ¹¹C radiochemistry."
  Journal of Labelled Compounds and Radiopharmaceuticals 58(3). 73-85 (2015) doi: 10.1002/jlcr.3253
• 8. Doi H., Goto M.,Suzuki M.:
  "Pd0 -Mediated Rapid C-[¹⁸F]Fluoromethylation by the Cross-Coupling Reaction of a [ ¹⁸ F]Fluoromethyl Halide with an Arylboronic Acid Ester: Novel Method for the Synthesis of a ¹⁸ F-Labeled Molecular Probe for Positron Emission Tomography."
  Bulletin of the Chemical Society of Japan 85. 1233-1238 (2012) doi: 10.1246/bcsj.20120151
• 9. Kuboyama T., Nakahara M., Yoshino M., et al.:
  "Stoichiometry-focused ¹⁸F-labeling of alkyne-substituted oligodeoxynucleotides using azido([¹⁸F]fluoromethyl)benzenes by Cu-catalyzed Huisgen reaction."
  Bioorganic & Medicinal Chemistry 19(1). 249-255 (2011) doi: 10.1016/j.bmc.2010.11.033
• 10. Doi H., Ban I., Nonoyama A., et al.:
  "Palladium(0)-mediated rapid methylation and fluoromethylation on carbon frameworks by reacting methyl and fluoromethyl iodide with aryl and alkenyl boronic acid esters: useful for the synthesis of [¹¹C]CH₃–C- and [¹⁸F]FCH₂–C-Containing PET tracers (PET=positron emission tomography)."
  Chemistry 15(16). 4165-4171 (2009) doi: 10.1002/chem.200801974

研究成果（プレスリリース）

• 

  2019年1月15日
  性ホルモン産生酵素が個人の性格・気質に関連する

関連リンク

メンバーリスト

お問い合わせ先