研究概要

主要論文

• 1.Doi, H., Sato, K., Shindou, H., Sumi, K., Koyama, H., Hosoya, T., Watanabe, Y., Ishii, S., Tsukada, H., Nakanishi, K., Suzuki, M.:
  “Blood-Brain Barrier Permeability of Ginkgolide: Comparison of the Behavior of PET Probes 7α-[¹⁸F]Fluoro- and 10-O-p-[¹¹C]Methylbenzyl Ginkgolide B in Monkey and Rat Brains”
  Bioorg. Med. Chem. 24, 5148–5157 (2016).
  
• 2.Doi H., Mawatari, A., Kanazawa, M., Nozaki, S., Nomura, Y., Kitayoshi, T., Akimoto, K., Suzuki, M., Ninomiya, Y. and Watanabe, Y.:
  "Synthesis of 11C-Labeled Thiamine and Fursultiamine for In Vivo Molecular Imaging of Vitamin B1 and Its Prodrug Using Positron Emission Tomography"
  J Org Chem, 80, 6250-6258 (2015).
• 3.Doi H.:
  "Pd-mediated rapid cross-couplings using [¹¹ C]methyl iodide: groundbreaking labeling methods in¹¹ C radiochemistry"
  J Labelled Comp Radiopharm., 58(3), 73-85 (2015).
• 4.Goto M, Mizuma H, Wada Y, Suzuki M, Watanabe Y, Onoe H, and Doi H.:
  "¹¹C-Labeled Capsaicin and Its in Vivo Molecular Imaging in Rats by Positron Emission Tomography"
  Food Nutr. Sci., 6(2), 216-220 (2015).
• 5.Doi, H., Goto, M. and Suzuki, M.:
  "Pd⁰-Mediated Rapid C-[¹⁸F]Fluoromethylation by the Cross-Coupling Reaction of a [¹⁸F]Fluoromethyl Halide with an Arylboronic Acid Ester: Novel Method for the Synthesis of a¹⁸F-Labeled Molecular Probe for Positron Emission Tomography"
  Bull. Chem. Soc. Jpn., 85, 1233-1238 (2012).
• 6.Kuboyama T, Nakahara M, Yoshino M, Cui Y, Sako T, Wada Y, Imanishi T, Obika S, Watanabe Y, Suzuki M, Doi H.:
  "Stoichiometry-focused¹⁸F-labeling of alkyne-substituted oligodeoxynucleotides using azido([¹⁸F]fluoromethyl)benzenes by Cu-catalyzed Huisgen reaction"
  Bioorg. Med. Chem., 19(1), 249-255 (2011).
• 7.Doi H, Ban I, Nonoyama A, Sumi K, Kuang C, Hosoya T, Tsukada H, Suzuki M.:
  "Palladium(0)-mediated rapid methylation and fluoromethylation on carbon frameworks by reacting methyl and fluoromethyl iodide with aryl and alkenyl boronic acid esters: useful for the synthesis of [¹¹C]CH(3)--C- and [¹⁸F]FCH2--C-Containing PET tracers (PET=positron emission tomography)"
  Chemistry., 15(16), 4165-4171 (2009).
• 8.Doi H, Barletta J, Suzuki M, Noyori R, Watanabe Y, Långström, B.:
  "Synthesis of¹¹C-labelled N,N’-diphenylurea and ethyl phenylcarbamate by a rhodium-promoted carbonylation via [¹¹C]isocyanatobenzene using phenyl azide and [¹¹C]carbon monoxide"
  Org Biomol Chem., 2(21), 3063-3066 (2004).
• 9.Suzuki, M., Doi, H., Kato, K., Bjorkman, M., Långström, B., Watanabe, Y. and Noyori, R. :
  "Rapid Methylation for the Synthesis of a¹¹C-Labeled Tolylisocarbacyclin Imaging the IP2 Receptor in a Living Human Brain"
  Tetrahedron, 56(42), 8263-8273 (2000).
• 10.Suzuki, M., Doi, H., Bjorkman, M., Andersson, Y., Långström, B., Watanabe, Y. and Noyori, R.:
  "Rapid Coupling of Methyl Iodide with Aryltributylstannanes Mediated by Palladium(0) Complexes: A General Protocol for the Synthesis of¹¹CH3-Labeled PET Tracers"
  Chem. Eur. J., 3(12), 2039-2042 (1997).

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