研究概要

研究成果（プレスリリース）

• 

  2019年5月20日
  がんの診断・治療につながる環状ペプチドを発見！

主要論文

• 1. Nomura S, Takahashi M, Hashiba Kato A, et al.:
  "Biosorption-based 64Cu-labeling of bacteria for pharmacokinetic positron-emission tomography"
  International Journal of Pharmaceutics 590. 119950 (2020) doi:10.1016/j.ijpharm.2020.119950
• 2. Mukai H, Watanabe Y.:
  "Review: PET imaging with macro- and middle-sized molecular probes."
  Nuclear Medicine and Biology, in press, doi:10.1016/j.nucmedbio.2020.06.007
• 3. Sakai K, Passioura T, Sato H, et al.:
  "Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor."
  Nature Chemical Biology 15. 598–606 (2019) doi: 10.1038/s41589-019-0285-7
• 4. Ren Q, Mohri K, Warashina S, et al.:
  "Improved immuno-PET imaging of HER2-positive tumors in mice: Urokinase injection-triggered clearance enhancement of 64Cu-trastuzumab."
  Molecular Pharmaceutics 16(3). 1065-1073 (2019) doi:10.1021/acs.molpharmaceut.8b01052
• 5. Mukai H, Hatanaka K, Yagi N, et al.:
  "Pharmacokinetic evaluation of liposomal nanoparticle-encapsulated nucleic acid drug: A combined study of dynamic PET imaging and LC/MS/MS analysis."
  Journal of Controlled Release 294. 185-194 (2019) doi: 10.1016/j.jconrel.2018.12.006
• 6. Nakamoto Y, Pradipta AR, Mukai H, et al.:
  "Expanding the applicability of the metal labeling of biomolecules by the RIKEN click reaction: A case study with Gallium‐68 positron emission tomography."
  Chembiochem 19. 2055-2060 (2018) doi: 10.1002/cbic.201800335
• 7. Matsumura K, Zouda M, Wada Y, et al.:
  "Urokinase injection-triggered clearance enhancement of a 4-arm PEG-conjugated 64Cu-bombesin analog tetramer: A novel approach for the improvement of PET imaging contrast."
  International Journal of Pharmaceutics 545. 206-214 (2018) doi:10.1016/j.ijpharm.2018.05.014
• 8. Mukai H, Takahashi M, Watanabe Y.:
  "Potential usefulness of Brevibacillus for bacterial cancer therapy: intratumoral provision of tumor necrosis factor- α and anticancer effects."
  Cancer Gene Therapy 25. 47-57 (2018) doi:10.1038/s41417-017-0009-7
• 9. Otani Y, Kawakami S, Mukai H, et al.:
  "Long-term in vivo gene expression in mouse kidney using φ31 integrase and electroporation."
  Journal of Drug Targeting 23. 427-435 (2015) doi:10.3109/1061186X.2014.1002788
• 10. Mukai H, Ozaki D, Cui YL, et al.:
  "Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with 18 F-incorporated oligodeoxynucleotides."
  Journal of Controlled Release 180. 92-99 (2014) doi:10.1016/j.jconrel.2014.02.014

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