研究概要

研究テーマ

• 微量細胞エピゲノムの包括的解析技術の開発
• 哺乳類発生過程におけるゲノム再プログラム化と細胞分化に関する研究
• 種々の生命現象の可視化・画像解析技術の開発

主要論文

「*」は、理研外のみでの成果です。

• 1.*Sugimoto, M., Kondo, M., Koga, Y., Shiura, H., Ikeda, R., Hirose, M., Ogura, A., Murakami, A., Yoshiki, A., Chuva de Sousa Lopes, S., Abe, K.:
  “A simple and robust method for establishing homogeneous mouse epiblast stem cell lines by Wnt inhibition.”
  Stem Cell Reports in press. (2015).
• 2.Shiura, H., Okamoto, A. Sasaki, H. and Abe, K.:
  “A novel technique for simultaneous visualization of specific DNA methylation and protein/RNA expression.”
  PLoS One. 9, e95750(2014)
• 3.Ikeda, R., Shiura, H., Numata, K., Sugimoto, M., Kondo, M., Mise, N., Suzuki, M., Greally, J.M. and Abe, K.:
  “Large, male germ cell-specific hypomethylated DNA domains with unique genomic and epigenomic features on the mouse X chromosome.”
  DNA Research 20, 549-565. (2013)
• 4.*Maeda, I., Okamura, D., Tokitake, Y., Ikeda, M., Kawaguchi, H., Mise, N., Abe, K., Noce, T., Okuda, A. and Matsui, Y.:
  “Max is a repressor of germ-cell-related gene expression in mouse embryonic stem cells.”
  Nature communications 4, 1754. (2013)
• 5.Shiura, H., Ikeda, R., Lee, J., Sato, T., Ogonuki, N., Hirose, M., Ogura, A., Ogawa, T., Abe, K.: “Generation of a novel germline stem cell line expressing a germline-specific reporter in the mouse.”
  genesis 51, 498-505. (2013).
• 6.*Semba, K., Araki, K., Matsumoto, K.-I., Suda, H., Ando, T. Sei, A., Mizuta, H., Takagi, K., Nakahara, M., Muta, M., Yamada, G., Nakagata, N., Iida, A., Ikegawa, Y., Araki, M., Abe, K. and Yamamura, K.:
  “The ectopic expression of Ptf1a induces spinal defects, urogenital defects and anorectal malformations in Danforth's short tail mice.”
  PLoS Genet. 9, e1003204. (2012)
• 7.Sugimoto, M., Kondo, M., Hirose, M., Suzuki, M., Mekada, K., Abe, T., Kiyonari, H., Ogura, A., Takagi, N., Artzt, K. and Abe, K.:
  “Molecular identification of t^w5: Vps52 promotes pluripotential cell differentiation through cell-cell interactions.”
  Cell Reports 2, 1363-1374. (2012).
• 8.*Okamura, D., Maeda, I., Taniguchi, H., Tokitake, Y., Ikeda, M., Ozato, K., Mise, N., Abe, K., Noce, T., Belmonte, J.C.I., Matsui, Y.:
  “Cell-cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells.”
  Genes Dev. 26, 2477-2482. (2012).
• 9.Cao, L, Kobayakawa, S., Yoshiki, A., Abe, K.:
  “High resolution intravital imaging of subcellular structures of mouse abdominal organs using a microstage device.”
  PLoS One e33876. (2012)
• 10.Kasahara, T., Abe, K., Mekada, K., Yoshiki, A., Kato, T.:
  “Genetic variation of melatonin productivity in laboratory mice under domestication.”
  Proc. Natl. Acad. Sci, USA 107, 6412-6417. (2010)

研究成果（プレスリリース）

• 

  2022年6月28日
  1細胞遺伝子発現解析用サンプル多重化のための新技術

• 

  2015年3月27日
  ヒト型多能性幹細胞の高効率樹立・安定維持技術を開発

• 

  2013年7月16日
  マウス生殖細胞から特徴的なエピゲノム領域を発見

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