研究概要

主要論文

• 1.Shin, C., Ito, Y., Ichikawa, S., Tokunaga, M., Sataka-Sogawa, K., Tanaka ,T.;
  “MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-kB and negatively regulates inflammatory responses”
  Sci. Rep. 7, 46097 (2017)
• 2.Ono, R., Kaisho, T., Tanaka, T.:
  “PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm”
  Sci. Rep. 5, 18327 (2015)
• 3.Tanaka, T., Shibazki, A., Ono, R., Kaisho, T.:
  “HSP70 mediates degradation of the p65 subunit ofnuclear factor κB to inhibit inflammatory signaling”
  Sci. Signal. 7(356), ra119 (2014)
• 4.Tanaka, T., Yamamoto, Y., Muromoto, R., Ikeda, O., Sekine, Y., Grusby, M.J., Kaisho, T., Matsuda, T.:
  “PDLIM2 inhibits T Helper 17 cell development and granulomatous inflammation through degradation of STAT3.”
  Sci. Signal. 4(202), ra85 (2011)
• 5.Kaisho, T. and Tanaka, T.:
  “Turning NF-κB and IRFs on and off in DCs.”
  Trends Immunol., 29, 329-336 (2008)
• 6.Tanaka, T. Grusby, M.J. and Kaisho, T.:
  “PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunit.”
  Nat. Immunol. 8, 584-591 (2007)
• 7.Nakahira, M., Tanaka, T., Robson, B.E., Mizgerd, J.P. and Grusby, M.J.:
  “Regulation of Signal Transducer and Activator of Transcription Signaling by the Tyrosine Phosphatase PTP-BL.”
  Immunity 26, 163-176 (2007)
• 8.Tanaka, T., Soriano, M.A. and Grusby, M.J.:
  “SLIM is a nuclear ubiquitin ligase that negatively regulates STAT signaling.”
  Immunity, 22, 729-736 (2005)

研究成果（プレスリリース）

• 

  2020年8月6日
  炎症反応を制御する新たな分子「PDLIM7」

• 

  2017年4月5日
  炎症反応を制御する新たな分子MKRN2を発見

• 

  2015年12月18日
  炎症反応を制御する新たな分子を発見

関連リンク

メンバーリスト

お問い合わせ先