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RIKEN Center for Advanced Intelligence Project

Cancer Translational Research Team

Team Leader: Ryuji Hamamoto (Ph.D.)
Ryuji  Hamamoto(Ph.D.)

We are conducting multimodal analysis of the omics data such as genome data, epigenome data, medical imaging data [CT, MRI, PET, endoscopy, pathology], proteome data, micro RNA data, cell line data, PDX [Patient-Derived Xenografts] data and clinical information in various types of cancers by machine learning and deep learning to clarify the nature of cancer. On the basis of our findings, we plan to develop novel diagnostic and therapeutic methods for cancer, and will also use them to develop novel anti-cancer drugs.

Main Research Field

Molecular Biology & Genetics

Related Research Fields

Biology & Biochemistry / Immunology / Clinical Medicine / Computer Science

Research Subjects

  • Analysis of histone modification status in cancer tissues by machine learning and deep learning
  • Analysis of medical imaging data by machine learning and deep learning
  • Multi-omics analysis of cancer by machine learning and deep learning

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.
  1. *Vassiliki Saloura, Theodore Vougiouklakis, Makda Zewde, Takehiro Suzuki, Naoshi Dohmae, Xiaolan Deng, Kazuma Kiyotani, Jae-Hyun Park, Yo Matsuo, Mark Lingen, Ryuji Hamamoto, Yusuke Nakamura:
    "WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR"
    Scientific Reports, 7, 40664 (2017)
  2. *Yuichiro Yoshioka, Takehiro Suzuki, Yo Matsuo, Makoto Nakakido, Giichiro Tsurita, Cristiano Simone, Toshiaki Watanabe, Naoshi Dohmae, Yusuke Nakamura, Ryuji Hamamoto:
    "SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1"
    Oncotarget, 7, 75023-75037 (2016)
  3. *Ryuji Hamamoto, Vassiliki Saloura, Yusuke Nakamura:
    "Critical roles of non-histone protein lysine methylation in human tumorigenesis"
    Nature Reviews Cancer, 15, 110-124 (2015)
  4. *Kenbun Sone, Lianhua Piao, Makoto Nakakido, Koji Ueda, Thomas Jenuwein, Yusuke Nakamura, Ryuji Hamamoto:
    "Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair"
    Nature Communications, 5, 5691 (2014)
  5. *Hyun-Soo Cho, Tadahiro Shimazu, Gouji Toyokawa, Yataro Daigo, Yoshihiko Maehara, Shinya Hayami, Akihiro Ito, Ken Masuda, Noriko Ikawa, Helen I. Field, Eiju Tsuchiya, Shin-ichi Ohnuma, Bruce A.J. Ponder, Minoru Yoshida, Yusuke Nakamura, Ryuji Hamamoto:
    "Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of aurora kinase B"
    Nature Communications, 3, 1072 (2012)
  6. *Kyohei Arita, Shin Isogai, Takashi Oda, Motoko Unoki, Kazuya Sugita, Naotaka Sekiyama, Keiko Kuwata, Ryuji Hamamoto, Hidehito Tochio, Mamoru Sato, Mariko Ariyoshi, Masahiro Shirakawa:
    "Recognition of modification status on a histone H3 tail by linked histone reader modules of UHRF1"
    Proc Natl Acad Sci USA, 109, 12950-12955 (2012)
  7. *Masashi Takawa, Hyun-Soo Cho, Shinya Hayami, Gouji Toyokawa, Masaharu Kogure, Yuka Yamane, Yukiko Iwai, Kazuhiro Maejima, Koji Ueda, Akiko Masuda, Naoshi Dohmae, Helen I. Field, Tatsuhiko Tsunoda, Takaaki Kobayashi, Takayuki Akasu, Masanori Sugiyama, Shin-ichi Ohnuma, Yutaka Atomi, Bruce A.J. Ponder, Yusuke Nakamura, Ryuji Hamamoto:
    "Histone Lysine Methyltransferase SETD8 Promotes Carcinogenesis by Deregulating PCNA Expression"
    Cancer Research, 72, 3217-3227 (2012)
  8. *Hyun-Soo Cho, Takehiro Suzuki, Naoshi Dohmae, Shinya Hayami, Motoko Unoki, Masanori Yoshimatsu, Gouji Toyokawa, Masashi Takawa, Taiping Chen, Julia K. Kurash, Helen I. Field, Bruce A.J. Ponder, Yusuke Nakamura, Ryuji Hamamoto:
    "Demethylation of MYPT1 by LSD1 promotes cell cycle progression in cancer cells"
    Cancer Research, 71, 1-6 (2011)
  9. *Masataka Tsuge, Ryuji Hamamoto, Fabio Pittella Silva, Yozo Ohnishi, Kazuaki Chayama, Naoyuki Kamatani, Yoichi Furukawa, Yusuke Nakamura:
    "VNTR Polymorphism of E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers"
    Nature Genetics, 37, 1104-1107 (2005)
  10. *Ryuji Hamamoto, Yoichi Furukawa, Masashi Morita, Yumiko Iimura, Fabio Pittella Silva, Meihua Li, Ryuichiro Yagyu, Yusuke Nakamura:
    "SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells"
    Nature Cell Biology, 6, 731-740 (2004)

Contact information

5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045

Email: ryuji.hamamoto [at] riken.jp

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