Centers & Labs

Chief Scientist Laboratories

Human biomimetic system RIKEN Hakubi Research Team

RIKEN Hakubi Team Leader: Masaya Hagiwara (Ph.D.)
Masaya  Hagiwara(Ph.D.)

The overall objective is the development of in-vitro experimental platform to reconstitute the biological system outside our bodies by controlling cellular micro-environments. Especially lung airway is the one of my major targets. The scientific question is how the airway cells can organize such a sophisticated structure by themselves. The repetitive feedbacks between in-vitro experiments and mathematical model give us a tremendous amount of useful information, and I am challenging to unveil the system underlying self-organization of tissue formation by directing complex tissue structure. Development of Organ or Body-on-a-Chip system is another research target for the animal testing alternative.

Main Research Field

Complex systems

Related Research Fields

Informatics / Interdisciplinary science and engineering / Mathematical and physical sciences / Chemistry / Engineering / Biological Sciences / Biology / Medicine, dentistry, and pharmacy

Biomedical engineering/Biomaterial science and engineering / Nano/Microsystems / Intelligent mechanics/Mechanical systems


  • In vitro tissue formation
  • Tissue imaging
  • Organ on a Chip
  • Culture Control

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.
  1. *Hagiwara, M., Nakase, I.:
    “Epidermal growth factor induced macropinocytosis directs branch formation of lung epithelial cells”
    Biochemical and Biophysical Research Communications, 507, 297-303, (2018).
  2. *Hagiwara, M., Nobata, R., Kawahara, T.:
    “High repeatability from 3D experimental platform for quantitative analysis of cellular branch pattern formations“
    Integrative Biology, 10, 306-312, (2018).
  3. *Hagiwara, M., Nobata, R., Kawahara, T.:
    “Large scale imaging by fine spatial alignment of multi-scanning data with gel cube device”
    Applied Sciences, 8, doi:10.3390/app8020235, (2018).
  4. *Hagiwara, M., Maruta, M., Marumoto, M.:
    “In Vitro Experimental Model for the Long-Term Analysis of Cellular Dynamics During Bronchial Tree Development from Lung Epithelial Cells”
    Tissue Engineering Part C: Methods, 23, 323-332, (2017).
  5. *Hagiwara, M:
    “An in vitro?in silico interface platform for spatiotemporal analysis of pattern formation in collective epithelial cells”
    Integrative Biology, 8, 861-868, (2016).
  6. *Hagiwara, M., Nobata, R., Kawahara, T.:
    “Tissue in Cube: In Vitro 3D Culturing Platform with Hybrid Gel Cubes for Multidirectional Observations”
    Advanced Healthcare Materials, 5, 1566-1571, (2016).
  7. *Hagiwara, M., Peng, F., Ho, CM.:
    “In vitro reconstruction of branched tubular structures from lung epithelial cells in high cell concentration gradient environment”
    Scientific Reports, 5, 8054, (2015)
  8. *Hagiwara, M., Kawahara, T., Iijima, T., Arai, F.:
    “High-Speed Magnetic Microrobot Actuation in a Microfluidic Chip by a Fine V-Groove Surface”
    IEEE Transactions on Robotics, vol. 29, issue 2, pp. 363-372, (2013).
  9. *Hagiwara, M., Kawahara, T., Arai, F.:
    “Local Streamline Generation by Mechanical Oscillation in a Microfluidic Chip for Noncontact Cell Manipulations”
    Applied Physics Letters, vol. 101, issue 7, pp. 074102-1 - 074102-4, 2012.
  10. *Hagiwara, M., Kawahara, T., Yamanishi, Y., Masuda, T., Arai, F.:
    “On-Chip Magnetically Actuated Robot with Ultrasonic Vibration for Single Cell Manipulations”
    Lab on a Chip, vol. 11, issue 12, pp. 2049-2054, (2011).

Contact Information

1-2 Gakuencho, Naka-ku,
Sakai, Osaka
599-8570, Japan