RIKEN Center for Sustainable Resource Science Catalysis and Integrated Research Group

Group Director: Mikiko Sodeoka (D.Phar.)

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Research Summary

Our group focuses on the development of new transition metal-catalyzed reactions　and exploitation of functions of the reaction products, and on conducting integrated research of plant science and chemistry with emphasis on sustainable resource science. In particular, we aim at developing methodologies for manipulation and/or modulation of structures and functions of organic molecules by catalytic oxidation reactions utilizing molecular oxygen, which will contribute to the effective utilization of carbon- and metal-based resources. In addition, investigation on the transformations of readily accessible natural organic molecules into valuable materials based on fine synthetic organic chemistry, as well as on the effective utilization of materials synthesized by newly developed reactions or from secondary metabolites of plants are of interest. In particular, we are studying various aspects of secondary metabolites of plants, whose effects on plants and animals have not been well clarified. Furthermore, this group will also contribute to enhance the collaboration between plant/microbiology research and chemical research activities inside CSRS.

Main Research Fields

Chemistry

Related Research Fields

Biological Sciences
Medicine, Dentistry & Pharmacy

Keywords

bioactive molecule
catalytic reaction
fluorine-containing molecule

Selected Publications

1. Mukherjee, S., Kawamura, S., and Sodeoka, M.:
"Ligand-Controlled Copper-Catalyzed Halo-Halodifluoromethylation of Alkenes and Alkynes Using Fluorinated Carboxylic Anhydrides"
Angew. Chem., Int. Ed., 63, e202407150 (2024).
2. Pünner, F., Sohtome, Y., Lyu, Y., Hashizume, D., Akakabe, M., Yoshimura, M., Yashiroda, Y., Yoshida, M., and Sodeoka, M.:
"Catalytic Aerobic Carbooxygenation for the Construction of Vicinal Tetrasubstituted Centers: Application to the Synthesis of Hexasubstituted γ-Lactones"
Angew. Chem., Int. Ed., 63, e202405876 (2024).
3. Hayamizu, K., Koike, K., Dodo, K., Asanuma, M., Egami, H., Sodeoka, M.:
"Simple purification of small-molecule-labelled peptides via palladium enolate formation from β-ketoamide tags"
Chem. Sci., 14, 8249–8254 (2023).
4. Nishiyama, R., Hiramatsu, K., Kawamura, S., Dodo, K., Furuya, K., de Pablo, J. G., Takizawa, S., Min, W., Sodeoka, M., Goda, K.:
"Color-scalable Flow Cytometry with Raman Tags "
PNAS Nexus, 2, pgad001 (2023)
5. Kawamura, S., Sodeoka, M.:
"Understanding and Controlling Fluorinated Diacyl Peroxides and Fluoroalkyl Radicals in Alkene Fluoroalkylations"
Chem. Rec., 23, e202300202 (2023).
6. Tagami, T., Mitani, Y., Kawamura, S., Sodeoka, M.:
"Catalytic Difluoromethylation of Alkenes with Difluoroacetic Anhydride: Reactivity of Fluorinated Diacyl Peroxides and Radicals"
Adv. Synth. Catal., 365, 3637–3647 (2023).
7. Toh, K., Nishio, K., Nakagawa, R., Egoshi, S., Abo, M., Perron, A., Sato, S.-i., Okumura, N., Koizumi, N., Dodo, K., Sodeoka, M., Uesugi, M.:
"Chemoproteomic Identification of Blue-Light-Damaged Proteins"
J. Am. Chem. Soc., 144, 20171–20176 (2022).
8. Dodo, K., Fujita, K., Sodeoka, M.:
"Raman Spectroscopy for Chemical Biology Research"
J. Am. Chem. Soc., 144, 19651–19667 (2022).
9. Egoshi, S., Dodo, K., Sodeoka, M.:
"Deuterium Raman Imaging for Lipid Analysis"
Curr. Opin. Chem. Biol., 70, 102181 (2022)
10. Egoshi, S., Dodo, K., Ohgane, K., Sodeoka, M.,
" Deuteration of terminal alkynes realizes simultaneous live cell Raman imaging of similar alkyne-tagged biomolecules"
Org. Biomol. Chem., 19, 8232-8236 (2021)