Centers & Labs

RIKEN Center for Sustainable Resource Science

Catalysis and Integrated Research Group

Group Director: Mikiko Sodeoka (D.Phar.)
Mikiko  Sodeoka(D.Phar.)

Our group focuses on the development of new transition metal-catalyzed reactions, and on conducting integrated research of plant science and chemistry with emphasis on sustainable resource science. In particular, we aim at developing methodologies for manipulation and/or modulation of structures and functions of organic molecules by catalytic oxidation reactions utilizing molecular oxygen, which will contribute to the effective utilization of carbon- and metal-based resources. In addition, investigation on the transformations of readily accessible natural organic molecules into valuable materials based on fine synthetic organic chemistry, as well as on the effective utilization of materials synthesized by newly developed reactions or from secondary metabolites of plants are of interest. In particular, we are studying various aspects of secondary metabolites of plants, whose effects on plants and animals have not been well clarified. Furthermore, this group will also contribute to enhance the collaboration between plant/microbiology research and chemical research activities inside CSRS.

Main Research Field


Related Research Fields

Biological Sciences / Medicine, dentistry, and pharmacy

Research Subjects

  • Development of catalytic transformations aiming at effective utilization of carbons, oxygens, and metals
  • Functional analysis of secondary metabolites and investigation on the use of them
  • Integrated Researches in CSRS

Selected Publications

  1. Sun, X., Hirai, G., Ueki, M., Hirota, H., Wang, Q., Hongo, Y., Nakamura, T., Hitora, Y., Takahashi, H., Sodeoka, M., Osada, H., Hamamoto, M., Yoshida, M., and Yashiroda, Y.:
    "Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast"
    Sci. Rep. 6, 20856 (2016).
  2. Kawamura, S., Egami, H., and Sodeoka, M.:
    "Aminotrifluoromethylation of Olefins via Cyclic Amine Formation: Its Mechanistic Study and Application to Synthesis of Trifluoromethylated Pyrrolidines"
    J. Am. Chem. Soc. 137, 4865-4873 (2015).
  3. Hayamizu, K., Terayama, N., Hashizume, D., Dodo, K. and Sodeoka, M.:
    "Unique features of chiral palladium enolates derived from β-ketoamide: Structure and catalytic asymmetric Michael and fluorination reactions"
    Tetrahedron, 71, 6594-6601 (2015).
  4. Egami, H. and Sodeoka, M.:
    "Recent Progress on Trifluoromethylation of Alkenes with Concomitant Introduction of Additional Functional Groups"
    Angew. Chem. Int. Ed. 53, 8294-8308 (2014).
  5. Egami, H., Shimizu, R., Usui, Y. and Sodeoka, M.:
    "Oxy-trifluoromethylation of alkenes and its application to the synthesis of β-trifluoromethylstyrene derivatives"
    J. Fluorine Chem. 167, 172-178 (2014).
  6. Miyazaki, M., Asanuma, M., Dodo, K., Egami, H., and Sodeoka, M.:
    "A Catch-and-Release Protocol for Alkyne-Tagged Molecules Based on a Resin-Bound Cobalt Complex for Peptide Enrichment in Aqueous Media"
    Chem. Eur. J. 20, 8116-8128 (2014).
  7. Ozawa, M., Morita, M., Hirai, G., Tamura, S., Kawai, M., Tsuchiya, A., Oonuma, K., Maruoka, K. and Sodeoka, M.:
    "Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Action"
    ACS Med. Chem. Lett. 4, 730-735 (2013).
  8. Egami, H., Shimizu, R., Kawamura, S., and Sodeoka, M.:
    "Alkene Trifluoromethylation Coupled with C-C Bond Formation: Construction of Trifluoromethylated Carbocycles and Heterocycles"
    Angew. Chem. Int. Ed. 52, 4000-4003 (2013).
  9. Egami, H., Shimizu, R. and Sodeoka, M.:
    "Concise synthesis of oxindole derivatives bearing a 3-trifluoroethyl group: Copper-catalyzed trifluoromethylation of acryloanilide"
    J. Fluorine Chem. 152, 51-55 (2013).
  10. Egami, H., Kawamura, S., Miyazaki, A., and Sodeoka, M.:
    "Trifluoromethylation Reactions for the Synthesis of β-Trifluoromethylamines"
    Angew. Chem. Int. Ed. 52, 7841-7844 (2013).

Lab Members

Principal Investigator

Mikiko Sodeoka
Group Director

Core Members

Go Hirai
Senior Research Scientist
Kosuke Dodo
Senior Research Scientist
Yoshihiro Sohtome
Research Scientist
Florian Punner
Postdoctoral Researcher
Shintaro Kawamura
Postdoctoral Researcher
Shigeru Yamaguchi
Postdoctoral Researcher
Kana Onuma
Technical Staff II

Contact information

S601 Chemistry and Materials Physics Building
2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Email: sodeoka [at]

Related links

Recent research results

August 19, 2016: RIKEN RESEARCH
A radical route to fluorine-containing molecules