Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Cancer Genomics

Team Leader: Hidewaki Nakagawa (M.D., Ph.D)
Hidewaki  Nakagawa(M.D., Ph.D)

Our laboratory is analyzing a large amount of human genome sequence data (whole genome, exome, and RNA-seq) by using cutting-edge next-generation sequencers and performing highly innovated informatics approach, and is providing basic genome information to clarify the relationship between genetic variations and cancer, human diseases, and drug response. We attend ICGC (International Cancer Genome Consortium) and dedicate in cancer genome sequencing to obtain a comprehensive description of cancer genome and to establish world-sharing database of cancer genome.

Main Research Field

Medicine, dentistry, and pharmacy

Related Research Fields

Informatics / Biological Sciences / Biology

Keywords

  • Cancer genomics
  • Precision Medicine
  • Next generation sequencer
  • Cancer immunogenomics

Selected Publications

  1. Nguyen DT, Nakagawa H, Nguyen HH, Nguyen Hai Ha, Nguyen Thuy Duong, Vu Phuong Nhung, Le Thi Thu Hien, Huynh Thi Thu Hue, Nguyen Huy Hoang, Jing Hao Wong, Nakano K, Maejima K, Sasaki-Oku A, Tsunoda T, Fujimoto A, and Nong Van Hai.:
    "Whole genome sequencing and mutation rate analysis of Vietnamese trios with paternal dioxin exposure."
    Human Mutation (2018) in press
  2. Furuta M, Tanaka H, Shiraishi Y, Unida T, Imamura M, Fujimoto A, Fujita M, Oku-Sasaki A, Maejima K, Nakano K, Kawakami Y, Arihiro K, Aikata H, Ueno M, Hayami S, Ariizumi S, Yamamoto M, Gotoh K, Ohdan H, Yamaue H, Miyano S, Chayama K, and Nakagawa H.:
    "Characterization of HBV integration patterns and timing in liver cancer and HBV-infected liver."
    Oncotarget 9:25075-25088 (2018)
  3. VanderWeele DJ, Finney R, Katayama K, Gillard M, Paner G, Imoto S, Yamaguchi R, Wheeler D, Cam M, Pontier A, Maejima K, Sasaki-Oku A, Nakano K, Tanaka H, Kubo M, Ratain MJ, Miyano S, and Nakagawa H.:
    "Genomic heterogeneity within individual prostate cancer foci impacts predictive biomarkers of targeted therapy."
    Eur Urol Focus S2405-4569(18)30007-5 (2018)
  4. Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T, Fujimoto A, Furuta M, Ruzzenente A, Conci S, Oosawa A, Sasaki-Oku A, Nakano K, Tanaka H, Yamamoto Y, Kubo M, Kawakami Y, Aikata H, Ueno M, Hayami S, Gotoh K, Ariizumi S, Yamamoto M, Yamaue H, Chayama K, Miyano S, Getz G, Scarpa A, Hirano S, Nakamura T, and Nakagawa H.:
    "Genomic characterization of biliary tract cancers identifies their driver genes and predisposing mutations."
    J Hepatol 68:959-969 (2018)
  5. Fujita M, Matsubara N, Matsuda I, Maejima K, Oosawa A, Yamano T, Fujimoto A, Furuta M, Nakano K, Oku-Sasaki A, Tanaka H, Shiraishi Y, Mateos RN, Nakai K, Miyano S, Tomita N, Hirota S, Ikeuchi H, and Nakagawa H.:
    "Genomic landscape of colitis-associated cancer indicates the impact of chronic inflammation and its stratification by mutations in RNF43 and Wnt signaling."
    Oncotarget 9:969-981 (2017)
  6. Furuta M, Ueno M, Fujimoto A, Hayami S, Yasukawa S, Kojima F, Arihiro K, Kawakami Y, Wardell CP, Shiraishi Y, Tanaka H, Nakano K, Maejima K, Sasaki-Oku A, Tokunaga N, Boroevich KA, Abe T, Aikata H, Ohdan H, Gotoh K, Kubo M, Tsunoda T, Miyano S, Chayama K, Yamaue H, and Nakagawa H.:
    "Whole genome sequencing discriminates hepatocellular carcinoma with intrahepatic metastasis from multi-centric tumors"
    J Hepatol 66: 363-373 (2017)
  7. Alexandrov LB, Ju Y, Haase K, Van Loo P, Martincorena I, Nik-Zainal S, Totoki Y, Fujimoto A, Nakagawa H, Shibata T, Campbell PJ, Vineis P, Phillips DH, and Stratton MR.:
    "Mutational signatures associated with tobacco smoking in human cancer."
    Science 354:618-622 (2016)
  8. Fujimoto A, Furuta M, Totoki Y, Tsunoda T, Kato M, Shiraishi Y, Tanaka H, Taniguchi H, Kawakami Y, Ueno M, Gotoh K, Ariizumi S, Wardell CP, Hayami S, Nakamura T, Aikata H, Arihiro K, Boroevich KA, Abe T, Nakano N, Maejima K, Sasaki-Oku A, Ohsawa A, Shibuya T, Nakamura H, Hama N, Hosoda F, Arai Y, Ohashi S, Urushidate T, Nagae G, Yamamoto S, Ueda H, Tatsuno K, Ojima H, Hiraoka N, Okusaka T, Kubo M, Marubashi S, Yamada T, Hirano S, Yamamoto M, Ohdan H, Shimada K, Ishikawa O, Yamaue H, Chayama K, Miyano S, Aburatani H, Shibata T, and Nakagawa H.:
    "Whole genome mutational landscape and characterization of non-coding and structural mutations in liver cancer."
    Nat Genet 48: 500-509 (2016)
  9. Wang M, Takahashi A, Liu F, Ye D, Ding Q, Qin C, Yin C, Zhang Z, Matsuda K, Kubo M, Na R, Lin X, Jiang H, Ren S, Sun J, Zheng SL, Le Marchand L, Isaacs WB, Mo1 Z, Haiman CA, Sun Y, Nakagawa H, and Xu J.:
    "Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer."
    Nat Commun 6:8469 (2015)
  10. Fujimoto A, Furuta M, Shiraishi Y, Gotoh K, Kawakami Y, Arihiro K, Nakamura T, Ueno M, Ariizumi S, Nguyen HH, Shigemizu D, Abe T, Boroevich KA, Nakano K, Sasaki A, Kitada R, Maejima K, Yamamoto Y, Tanaka H, Shibuya T, Shibata T, Ojima H, Shimada K, Hayami S, Shigekawa Y, Aikata H, Ohdan H, Marubashi S, Yamada T, Kubo K, Hirano S, Ishikawa O, Yamamoto M, Yamaue H, Chayama K, Miyano S, Tsunoda T, and Nakagawa H.:
    "Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity."
    Nat Commun 6: 6120 (2015)

Lab Members

Principal Investigator

Hidewaki Nakagawa
Team Leader

Core Members

Masashi Fujita
Research Scientist
Kaoru Nakano
Technical Staff II
Kazuhiro Maejima
Technical Staff II
Ayako Oosawa
Technical Staff II
Aya Oku
Technical Staff II

Contact information

4-6-1 Shirokanedai, Minato-ku, Tokyo,
108-8639, Japan
The Institute of Medical Science, The University Of Tokyo
Tel: +81-(0)3-5449-5785
Fax: +81-(0)3-5449-5785

Email: hidewaki [at] ims.u-tokyo.ac.jp

Related links

Further information