Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Genome Sequencing Analysis

Team Leader: Hidewaki Nakagawa (M.D., Ph.D)
Hidewaki  Nakagawa(M.D., Ph.D)

Our laboratory is analyzing a large amount of human genome sequence data (whole genome, exome, and RNA-seq) by using cutting-edge next-generation sequencers and performing highly innovated informatics approach, and is providing basic genome information to clarify the relationship between genetic variations and cancer, human diseases, and drug response. We attend ICGC (International Cancer Genome Consortium) and dedicate in cancer genome sequencing to obtain a comprehensive description of cancer genome and to establish world-sharing database of cancer genome.

Main Research Field

Molecular Biology & Genetics

Related Research Fields

Biology & Biochemistry / Clinical Medicine / Computer Science

Research Subjects

  • Whole genome sequencing (WGS) analysis by next-generation sequencer
  • Cancer genome
  • Genome-wide association study (GWAS) for cancer
  • Personalized and precise medicine

Selected Publications

  1. Tyler S, et al.:
    "A comprehensive assessment of somatic mutation detection in cancer using whole genome sequencing."
    Nature Communications 6: 10001 (2015)
  2. Nakagawa H, Wardell CP, Furuta M, Taniguchi H, and Fujimoto A.:
    "Cancer whole genome sequencing: present and future. (review)"
    Oncogene 34: 5943-5950 (2015)
  3. Wang M, Takahashi A, Liu F, Ye D, Ding Q, Qin C, Yin C, Zhang Z, Matsuda K, Kubo M, Na R, Lin X, Jiang H, Ren S, Sun J, Zheng SL, Le Marchand L, Isaacs WB, Mo1 Z, Haiman CA, Sun Y, Nakagawa H, and Xu J.:
    "Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer."
    Nature Communications 6:8469 (2015)
  4. Ono A, Fujimoto A, Yamamoto Y, Akamatsu S, Hiraga N, Imamura M, Kawaoka T, Tsuge M, Abe H, Hayes CN, Miki D, Furuta M, Tsunoda T, Miyano S, Kubo M, Aikata H, Ochi H, Kawakami Y, Nakagawa H, and Chayama K.:
    "Circulating tumor DNA analysis for liver cancers and its usefulness as a liquid biopsy."
    Cell Mol Gastroenterol Hepatol 1: 516-534 (2015)
  5. Fujimoto A, Furuta M, Shiraishi Y, Gotoh K, Kawakami Y, Arihiro K, Nakamura T, Ueno M, Ariizumi S, Nguyen HH, Shigemizu D, Abe T, Boroevich KA, Nakano K, Sasaki A, Kitada R, Maejima K, Yamamoto Y, Tanaka H, Shibuya T, Shibata T, Ojima H, Shimada K, Hayami S, Shigekawa Y, Aikata H, Ohdan H, Marubashi S, Yamada T, Kubo K, Hirano S, Ishikawa O, Yamamoto M, Yamaue H, Chayama K, Miyano S, Tsunoda T, and Nakagawa H.:
    "Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity."
    Nature Communications 6: 6120 (2015)
  6. Al Olama AA, et al.:
    "A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer"
    Nature Genetics 46: 1103-1109 (2014)
  7. Akamatsu S, Takahashi A, Takata R, Kubo M, Inoue T, Morizono T, Tsunoda T, Kamatani N, Haiman CA, Wan P, Chen GK, Le Marchand L, Kolonel LN, Henderson BE, Fujioka T, Habuchi T, Nakamura Y, Ogawa O, and Nakagawa H.: 
    "Reproducibility, performance, and clinical utility of a genetic risk prediction model for prostate cancer in Japanese."
    PLoS ONE 7:e46454 (2012)
  8. Fujimoto A, Totoki Y, Abe T, Boroevich KA, Hosoda F, Nguyen HH, Aoki M, Hosono N, Kubo M, Miya F, Arai Y, Takahashi H, Shirakihara T, Nagasaki M, Shibuya T, Nakano K, Watanabe-Makino K, Tanaka H, Nakamura H, Kusuda J, Ojima H, Shimada K, Okusaka T, Ueno M, Shigekawa Y, Kawakami Y, Arihiro K, Ohdan H, Gotoh K, Ishikawa O, Ariizumi S, Yamamoto M, Yamada T, Chayama K, Kosuge T, Yamaue H, Kamatani N, Miyano S, Nakagama H, Nakamura Y, Tsunoda T, Shibata T, and Nakagawa H.:
    "Whole genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators."
    Nature Genetics 44: 760-764 (2012)
  9. Akamatsu S, Takata R, Haiman CA, Takahashi A, Inoue T, Kubo M, Furihata M, Kamatani N, Inazawa J, Chen GK, Le Marchand L, Kolonel LN, Katoh T, Yamano Y, Yamakado M, Takahashi H, Yamada H, Egawa S, Fujioka T, Henderson BE, Habuchi T, Ogawa O, Nakamura Y, and Nakagawa H.: 
    "Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese."
    Nature Genetics 44: 426-429 (2012)

Lab Members

Principal Investigator

Hidewaki Nakagawa
Team Leader

Core Members

Hiroaki Taniguchi
Research Scientist
Mayuko Furuta
Research Scientist
Kaoru Nakano
Technical Staff II
Kazuhiro Maejima
Technical Staff II

Contact information

4-6-1 Shirokanedai, Minato-ku, Tokyo,
108-8639, Japan
The Institute of Medical Science, The University Of Tokyo
Tel: +81-(0)3-5449-5785
Fax: +81-(0)3-5449-5785

Email: hidewaki [at]

Related links

Recent research results

July 1, 2016: RIKEN RESEARCH
Liver cancer’s genomic landscape
April 17, 2015: RIKEN RESEARCH
An infectious imprint on liver cancer
January 30, 2015: Press Release
Hot on the trail of the hepatitis-liver cancer connection

Further information