Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Immune Homeostasis

Team Leader: Taishin Akiyama (Ph.D.)
Taishin  Akiyama(Ph.D.)

Disruption of immune systems can cause many types of diseases such as immunodeficiency, autoimmune diseases, allergy and tumor. Our team focuses on mechanisms establishing T cell self-tolerance in the thymus, which providing an environment for T cell differentiation. Several lines of evidence revealed critical roles of epithelial cells in the thymic medulla (medullary thymic epithelial cells; mTECs) for selecting self-tolerant T cells and regulatory T cells, thereby preventing onset of autoimmune diseases and controlling anti-tumor immunity. Our team aims to clarify mechanisms regulating function, differentiation, and maintenance of mTECs and to utilize the mTEC function for controlling immune-related diseases.

Main Research Field

Medicine, dentistry, and pharmacy

Related Research Fields

Biology

Keywords

  • Immune disorder
  • T lymphocytes
  • Thymus

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.
  1. *Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM., Kobayashi Y, Inoue J, and Akiyama T.:
    "Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator"
    J. Exp. Med. 213: 1441-1458 (2016)
  2. *Tateishi R, Akiyama N, Miyauchi M, Yoshinaga R, Sasanuma H, Kudo T, Shimbo M, Shinohara M, Obata K, Inoue J, Shirakawa M, Shiba D, Asahara H, Yoshida N, Takahashi S, Morita H, and Akiyama T.:
    "Hypergravity provokes a temporary reduction in CD4+CD8+ thymocyte number and a persistent decrease in medullary thymic epithelial cell frequency in mice"
    Plos one., 10: e0141650 (2015)
  3. *Akiyama N., Shinzawa M., Miyauchi M., Yanai H., Tateishi R., Shimo Y., Ohshima D., Matsuo K., Sasaki I., Hoshino K., Wu G., Yagi S. Inoue J., Kaisho T., and Akiyama T.:
    "Limitation of immune tolerance–inducing thymic epithelial cell development by Spi-B–mediated negative feedback regulation"
    J. Exp. Med., 211: 2425-2438 (2014)

Lab Members

Principal Investigator

Taishin Akiyama
Team Leader

Core Members

Takako Kato
Technical Staff I
Takahisa Miyao
Technical Staff I

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-7069