Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Integrative Genomics

Group Director: Osamu Ohara (Ph.D.)
Osamu  Ohara(Ph.D.)

The very basic mission of integrative genomics group is to function as a “Gateway” to genomics for medical scientists. To achieve this mission at the center, we have pronged our research activities into three parts as follows: (1) central support activities; (2) strategic and collaborative research activities; and (3) exploratory research activities aimed at new technology development. In particular, based on our previously developed single-cell analysis methods, we are integrating analyses in population context and along time axis to uncover new aspects of dynamics of the biological systems as the main exploratory research activities.

Main Research Field

Molecular Biology & Genetics

Related Research Fields

Biology & Biochemistry / Immunology / Clinical Medicine / Multidisciplinary

Research Subjects

  • Single-cell analysis of protein secretion
  • Technical development for proteomic and transcriptomic analyses of the immune system
  • Construction of immunogenomics database
  • Analysis of primary immunodeficiency diseases

Selected Publications

  1. Yakushiji-Kaminatsui N, Kondo T, Endo TA, Koseki Y, Kondo K, Ohara O, Vidal M, Koseki H.:
    "RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression."
    Development. 143(2), 276-85 (2016)
  2. Najima Y, Tomizawa-Murasawa M, Saito Y, Watanabe T, Ono R, Ochi T, Suzuki N, Fujiwara H, Ohara O, Shultz LD, Yasukawa M, Ishikawa F.:
    "Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice."
    Blood. 127(6), 722-34 (2016)
  3. Kaji T, Hijikata A, Ishige A, Kitami T, Watanabe T, Ohara O, Yanaka N, Okada M, Shimoda M, Taniguchi M, Takemori T.:
    "CD4 memory T cells develop and acquire functional competence by sequential cognate interactions and stepwise gene regulation."
    Int Immunol. in press
  4. Inoue T, Morita M, Hijikata A, Fukuda-Yuzawa Y, Adachi S, Isono K, Ikawa T, Kawamoto H, Koseki H, Natsume T, Fukao T, Ohara O, Yamamoto T, Kurosaki T.:
    "CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability."
    J Exp Med. 212(9), 1465-79 (2015)
  5. Yasutomi M, Yoshioka K, Mibayashi A, Tanizawa A, Imai K, Ohara O, Ohshima Y.:
    "Successful Myeloablative Bone Marrow Transplantation in an Infant With Wiskott-Aldrich Syndrome and Bacillus Calmette-Guerin Infection."
    Pediatr Blood Cancer. 62(11), 2052-3 (2015)
  6. Oda H, Sato T, Kunishima S, Nakagawa K, Izawa K, Hiejima E, Kawai T, Yasumi T, Doi H, Katamura K, Numabe H, Okamoto S, Nakase H, Hijikata A, Ohara O, Suzuki H, Morisaki H, Morisaki T, Nunoi H, Hattori S, Nishikomori R, Heike T.:
    "Exon skippingcauses atypical phenotypes associated with a loss-of-function mutation in FLNA by restoring its protein function."
    Eur J Hum Genet. 24(3), 408-14 (2016)
  7. Hijikata A, Yura K, Ohara O, Go M.:
    "Structural and functional analyses of Barth syndrome-causing mutations and alternative splicing in the tafazzin acyltransferase domain."
    Meta Gene. 4, 92-106 (2015)
  8. Yasumi T, Hori M, Hiejima E, Shibata H, Izawa K, Oda H, Yoshioka K, Nakagawa K, Kawai T, Nishikomori R, Ohara O, Heike T.:
    "Laboratory parameters identify familial haemophagocytic lymphohistiocytosis from other forms of paediatric haemophagocytosis."
    Br J Haematol. 170(4), 532-8 (2015)
  9. Kato T, Crestani E, Kamae C, Honma K, Yokosuka T, Ikegawa T, Nishida N, Kanegane H, Wada T, Yachie A, Ohara O, Morio T, Notarangelo LD, Imai K, Nonoyama S.:
    "RAG1 deficiency may present clinically as selective IgA deficiency."
    J Clin Immunol. 35(3), 280-8 (2015)
  10. Aoki Y, Watanabe T, Saito Y, Kuroki Y, Hijikata A, Takagi M, Tomizawa D, Eguchi M, Eguchi-Ishimae M, Kaneko A, Ono R, Sato K, Suzuki N, Fujiki S, Koh K, Ishii E, Shultz LD, Ohara O, Mizutani S, Ishikawa F.:
    "Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia."
    Blood. 125:967-80 (2015)

Lab Members

Principal Investigator

Osamu Ohara
Group Director

Core Members

Takaho Endo
Senior Research Scientist
Takashi Watanabe
Senior Research Scientist
Junshi Yazaki
Senior Research Scientist
Yusuke Kawashima
Research Scientist
Tomoko Hasegawa
Technical Scientist
Yoshiki Mochizuki
Technical Scientist
Mikihiro Hashimoto
Postdoctoral Researcher
Emi Ishikuro
Technical Staff I
Fumie Yokoyama
Technical Staff I
Juri Shioya
Technical Staff II

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan

Email: osamu.ohara [at] riken.jp

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