Centers & Labs

RIKEN Center for Integrative Medical Sciences

Laboratory for Pharmacogenomics

Group Director: Taisei Mushiroda (Ph.D.)
Taisei  Mushiroda(Ph.D.)

The Laboratory for Pharmacogenetics aims to identify genes associated with drug efficacy and adverse drug reactions, leading to the establishment of personalized therapeutics based on pharmacogenomics.
A combination of genetic variations and environmental differences defines unique human characteristics, including individual responsiveness (effectiveness and adverse reaction) to drugs. Among several types of genetic variation, single-nucleotide polymorphisms (SNPs) are the most abundant throughout the genome. SNPs have lately received much attention in biomedical fields, because some of them can influence the quality and/or the quantity of particular gene products, and thereby serve as markers of individual risk for adverse drug reactions or susceptibility to complex diseases. We expect the genomic approach, by exploiting an already large collection of SNPs and haplotype maps based on that collection, to revolutionize drug discovery and development, as well as the practice of medicine, within the next 5-10 years. Genetic variations in genes encoding proteins involved in drug metabolism, transport and response are of increasing importance for selecting particular drugs and an optimal dosages to provide the maximum effect and minimal adverse reactions for individual patients. The SNP-based approach makes us confident of achieving one of our goals, which is establishment of 'personalized medicine' that can provide the right drug at the appropriate dose for each individual patient.

Main Research Field

Medicine, dentistry, and pharmacy

Research Subjects

  • Identification of gene(s) associated with drug responses

Selected Publications

  1. Low JS, Chin YM, Mushiroda T, Kubo M, Govindasamy GK, Pua KC, Yap YY, Yap LF, Subramaniam SK, Ong CA, Tan TY, Khoo AS; Malaysian NPC Study Group, Ng CC.:
    "A genome wide study of copy number variation associated with nasopharyngeal carcinoma in Malaysian Chinese identifies CNVs at 11q14.3 and 6p21.3 as candidate loci"
    PLoS One 11:e0145774 (2016)
  2. Chin YM, Mushiroda T, Takahashi A, Kubo M, Krishnan G, Yap LF, Teo SH, Lim PV, Yap YY, Pua KC, Kamatani N, Nakamura Y, Sam CK, Khoo AS; Malaysian NPC Study Group, Ng CC.:
    "HLA-A SNPs and amino acid variants are associated with nasopharyngeal carcinoma in Malaysian Chinese"
    Int J Cancer 136:678-87 (2015)
  3. Miura Y, Imamura CK, Fukunaga K, Katsuyama Y, Suyama K, Okaneya T, Mushiroda T, Ando Y, Takano T, Tanigawara Y.:
    "Sunitinib-induced severe toxicities in a Japanese patient with the ABCG2 421 AA genotype"
    BMC Cancer 14:964 (2014)
  4. Province MA, Goetz MP, Brauch H, Flockhart DA, Hebert JM, Whaley R, Suman VJ, Schroth W, Winter S, Zembutsu H, Mushiroda T, Newman WG, Lee MT, Ambrosone CB, Beckmann MW, Choi JY, Dieudonné AS, Fasching PA, Ferraldeschi R, Gong L, Haschke-Becher E, Howell A, Jordan LB, Hamann U, Kiyotani K, Krippl P, Lambrechts D, Latif A, Langsenlehner U, Lorizio W, Neven P, Nguyen AT, Park BW, Purdie CA, Quinlan P, Renner W, Schmidt M, Schwab M, Shin JG, Stingl JC, Wegman P, Wingren S, Wu AH, Ziv E, Zirpoli G, Thompson AM, Jordan VC, Nakamura Y, Altman RB, Ames MM, Weinshilboum RM, Eichelbaum M, Ingle JN, Klein TE.:
    "CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-Analysis of Heterogeneous Study Populations"
    Clin Pharmacol Ther 95:216-27 (2014)
  5. Perera MA, Cavallari LH, Limdi NA, Gamazon ER, Konkashbaev A, Daneshjou R, Pluzhnikov A, Crawford DC, Wang J, Liu N, Tatonetti N, Bourgeois S, Takahashi H, Bradford Y, Burkley BM, Desnick RJ, Halperin JL, Khalifa SI, Langaee TY, Lubitz SA, Nutescu EA, Oetjens M, Shahin MH, Patel SR, Sagreiya H, Tector M, Weck KE, Rieder MJ, Scott SA, Wu AH, Burmester JK, Wadelius M, Deloukas P, Wagner MJ, Mushiroda T, Kubo M, Roden DM, Cox NJ, Altman RB, Klein TE, Nakamura Y, Johnson JA.:
    "Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study"
    Lancet 382:790-6 (2013)
  6. Low SK, Chung S, Takahashi A, Zembutsu H, Mushiroda T, Kubo M, Nakamura Y.:
    "Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan"
    Cancer Sci 1041074-82 (2013)
  7. Hershfield MS, Callaghan JT, Tassaneeyakul W, Mushiroda T, Thorn CF, Klein TE, Lee MT.:
    "Clinical Pharmacogenetics Implementation Consortium guidelines for human leukocyte antigen-B genotype and allopurinol dosing"
    Clin Pharmacol Ther 93:153-8 (2013)
  8. Kiyotani K, Uno S, Mushiroda T, Takahashi A, Kubo M, Mitsuhata N, Ina S, Kihara C, Kimura Y, Yamaue H, Hirata K, Nakamura Y, Zembutsu H.:
    "A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy"
    Pharmacogenet Genomics 22: 229-35 (2012)
  9. Kiyotani K, Mushiroda T, Tsunoda T, Morizono T, Hosono N, Kubo M, Tanigawara Y, Imamura CK, Flockhart DA, Aki F, Hirata K, Takatsuka Y, Okazaki M, Ohsumi S, Yamakawa T, Sasa M, Nakamura Y, Zembutsu H.:
    "A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese"
    Hum Mol Genet 21: 1665-72 (2012)
  10. Kiyotani K, Mushiroda T, Imamura CK, Tanigawara Y, Hosono N, Kubo M, Sasa M, Nakamura Y, Zembutsu H.:
    "Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients"
    Breast Cancer Res Treat 131: 137-45 (2012)

Lab Members

Principal Investigator

Taisei Mushiroda
Group Director

Core Members

Takeshi Ozeki
Research Scientist
Koya Fukunaga
Research Scientist
Keiko Hikino
Research Associate
Tomoko Yoshihama
Junior Research Associate
Mitsunori Yahata
Technical Staff I
Shoko Higuchi
Technical Staff II
Yuko Ohta
Technical Staff II
Aiko Oono
Technical Staff II
Yuuka Kikuchi
Technical Staff II

Contact information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan

Email: mushiroda [at] riken.jp

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