RIKEN Center for Integrative Medical Sciences (IMS)
Director: Masayuki Amagai (M.D., Ph.D.)
Our goal is to understand how diseases develop in our aging society, aiming to explore these diseases from new perspectives to identify novel approaches for treatment and prevention. To this end, four key research areas have been identified: (1) integrated analysis of the human immune system, (2) research on pathological molecular mechanisms through organ linkage analysis, (3) research on non-coding genomic medicine, and (4) development of innovative therapeutic methods. Laboratories focused on these objectives collaborate closely. We employ multi-omics analyses across the genome, gene expression, proteins, lipids, cells, tissues, and individuals, utilizing computational methods, including statistics and AI technology. Additionally, we have established a platform to enhance our understanding of results obtained from experimental animals and apply these findings to human immunology research. This platform also supports the elucidation of human pathology mechanisms through experimental systems, such as cell and animal models, and these infrastructures are being leveraged to advance next-generation research.
Organization
- Laboratory for Regulatory Genomics
- Chung Chau Hon (Ph.D.)
- Laboratory for Inflammatory Immune Metabolism
- Sonia Sharma (Ph.D.)
- Laboratory for Infectious Diseases and Immunology
- Kosuke Miyauchi (Ph.D.)
- Laboratory for Cancer Genomics
- Hidewaki Nakagawa (M.D., Ph.D)
- Laboratory for Cancer Invasion and Metastasis
- Mikako Shirouzu (Ph.D.)
- Laboratory for Genotyping Development
- Yukihide Momozawa (D.V.M., Ph.D.)
- Laboratory for Symbiotic Microbiome Sciences
- Wataru Suda (D.Agr.)
- Laboratory for Statistical and Translational Genetics
- Chikashi Terao (M.D., Ph.D)
- Laboratory for Advanced Biomolecular Engineering
- Shunsuke Tagami (Ph.D.)
- Laboratory for Bottom-up Cell Biology
- Makito Miyazaki (Ph.D.)
- Laboratory for Cellular Function Conversion Technology
- Harukazu Suzuki (Ph.D.)
- Laboratory for Autoimmune Diseases
- Kazuhiko Yamamoto (M.D., Ph.D)
- Laboratory for Systems Genetics
- Yukinori Okada (M.D., Ph.D)
- Laboratory for Innate Immune Systems
- Kazuyo Moro (Ph.D.)
- Laboratory for Epigenome Inheritance
- Azusa Inoue (Ph.D.)
- Laboratory for Cardiovascular Genomics and Informatics
- Kaoru Ito (M.D., Ph.D)
- Laboratory for Gut Homeostasis
- Kenya Honda (M.D., Ph.D)
- Laboratory for Structure-Based Molecular Design
- Teruki Honma (Ph.D.)
- Laboratory for In situ Structural Biology
- Reiya Taniguchi (Ph.D.)
- Laboratory for Dynamic Biomolecule Design
- Ai Niitsu (Ph.D.)
- Laboratory for Dynamic Structure of Biomolecules
- Ichio Shimada (Ph.D.)
- Laboratory for Large-Scale Biomedical Data Technology
- Takeya Kasukawa (Ph.D.)
- Laboratory for Biomedical Ethics and Co-design
- Muto Kaori (Ph.D.)
- Laboratory for Tissue Dynamics
- Takaharu Okada (Ph.D.)
- Laboratory for Metabolic Networks
- Toshimori Kitami (Ph.D.)
- Laboratory for Protein Functional and Structural Biology
- Mikako Shirouzu (Ph.D.)
- Laboratory for Transcription Structural Biology
- Shun-ichi Sekine (Ph.D.)
- Laboratory for Integrative Genomics
- Jun Seita (M.D., Ph.D.)
- Laboratory for Integrated Cellular Systems
- Katsuyuki Yugi (Ph.D.)
- Laboratory for Transcriptome Technology
- Piero Carninci (Ph.D.)
- Laboratory for Intestinal Ecosystem
- Hiroshi Ohno (M.D., Ph.D)
- Laboratory for Mucosal Immunity
- Sidonia Fagarasan (M.D., Ph.D)
- Laboratory for Functional Non-coding Genomics
- Yuka Iwasaki (Ph.D.)
- Laboratory for Human Disease Models
- Fumihiko Ishikawa (M.D., Ph.D)
- Laboratory for Human Immunogenetics
- Kazuyoshi Ishigaki (M.D., Ph.D)
- Laboratory for Skin Homeostasis
- Masayuki Amagai (M.D., Ph.D)
- Laboratory for Pharmacogenomics
- Taisei Mushiroda (Ph.D.)
- Laboratory for Lymphocyte Differentiation
- Tomohiro Kurosaki (M.D., Ph.D)
- Laboratory for Translation Structural Biology
- Takuhiro Ito (Ph.D.)
- Laboratory for Metabolomics
- Makoto Arita (Ph.D.)
- Laboratory for Immunological Memory
- Shiki Takamura (D.V.M., Ph.D.)
- Laboratory for Developmental Genetics
- Haruhiko Koseki (M.D., Ph.D)
- Laboratory for Immune Homeostasis
- Taishin Akiyama (Ph.D.)
- Laboratory for Immunotherapy
- Shin-ichiro Fujii (M.D., Ph.D)
- Laboratory for Transcriptional Regulation
- Ichiro Taniuchi (M.D., Ph.D)
- RIKEN-IFOM Joint Laboratory for Cancer Genomics
- Yasuhiro Murakawa (M.D., Ph.D)
- Laboratory for Retrotransposon Dynamics
- Tomoichiro Miyoshi (Ph.D.)
- Epigenome Dynamics RIKEN ECL Research Team
- Shihori Yokobayashi (Ph.D.)
- Young Chief Investigator Program
- Hiroshi Ohno (M.D., Ph.D.)
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- Proteome Homeostasis Research Unit
- Koshi Imami (Ph.D.)
- Precision Immune Regulation RIKEN ECL Research Unit
- Naoko Satoh-Takayama (Ph.D.)
- Advanced Multi-Omics Technology Division
- Takaharu Okada (Ph.D.)
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- Spatial Omics Collaborative Project
- Takaharu Okada (Ph.D.)
- Data Informatics Collaborative Project
- Takaharu Okada (Ph.D.)
- Cryo-EM Operation Team
- Shun-ichi Sekine (Ph.D.)
- NMR Operation Team
- Ichio Shimada (Ph.D.)
- Genomics and Transcriptomics Unit
- Yukihide Momozawa (D.V.M., Ph.D.)
- Cellular Function Analysis Support Unit
- Takaharu Okada (Ph.D.)
- Laboratory Animals Support Unit
- Haruhiko Koseki (M.D., Ph.D.)
- Proteomics Unit
- Jun Seita (M.D., Ph.D.)
- Lipidomics and Metabolomics Unit
- Makoto Arita (Ph.D.)
- Predictive Medicine Special Project
- Kazuhiro Sakurada (Ph.D.)
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- Open Systems Information Science Special Team
- Kazuhiro Sakurada (Ph.D.)
- Medical Data Mathematical Reasoning Special Team
- Eiryo Kawakami (M.D., Ph.D.)
- Medical Data Deep Learning Team
- Jun Seita (M.D., Ph.D.)
- Data Science and Design Special Team
- Masayuki Ihara (Ph.D.)
- Drug Discovery Structural Biology Platform Unit
- Mikako Shirouzu (Ph.D.)
- Drug Discovery Computational Chemistry Platform Unit
- Teruki Honma (Ph.D.)
- aAVC Drug Translational Unit
- Shin-ichiro Fujii (M.D., Ph.D)
- Next-Generation Magnet Development Collaboration Unit
- Yoshinori Yanagisawa (Ph.D.)
Recent Research Results
Jun. 5, 2024
Cracking the aging code: Insights into lipid changes
Mar. 15, 2024
Gut bacteria important for overcoming milk allergy
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Contact Information
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama, Kanagawa
230-0045, Japan
Contact | RIKEN Center for Integrative Medical Sciences