Research Summary

Selected Publications

• 1.Koda, Y., Kikuzato, K., Mikuni, J., Tanaka, A., Yuki, H., Honma, T., Tomabechi, Y., Kukimoto-Niino, M., Shirouzu, M., Shirai, F. and Koyama, H.:
  “Identification of pyrrolo[2,3-d]pyrimidines as potent HCK and FLT3-ITD dual inhibitors”
  Bioorganic & Medicinal Chemistry Letters 27(22), 4944-4998. (2017).
• 2.Shoji, S, Hanada, K., Ohsawa, N. and Shirouzu, M.:
  “Central catalytic domain of BRAP (RNF52) recognizes the types of ubiquitin chains and utilizes oligo-ubiquitin for ubiquitylation”
  Biochemical Journal 474(18), 3207-3226. (2017)
• 3.Yuki, H, Kikuzato, K., Koda, Y., Mikuni, J., Tomabechi, Y., Kukizato-Niino, M., Tanaka, A., Shirai, F., Shirouzu, M., Koyama, H. and Honma, T.:
  “Activity cliff for 7-substituted pyrrolo-pyrimidine inhibitors of HCK explained in terms of predicted basicity of the amine nitrogen”
  Bioorganic & Medicinal Chemistry 25(16), 4259-4264. (2017).
• 4.Amano, Y., Kikuchi, M., Sato, S., Yokoyama, S., Umehara, T., Umezawa, N. and Higuchi, T.:
  “Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1”
  Bioorganic & Medicinal Chemistry 25(9), 2617-2624. (2017).
• 5.Takemoto, Y., Ito, A., Niwa, H., Okumura, M., Fujiwara, T., Hirano, T., Handa, N., Umehara, T., Sonoda, T., Ogawa K., Tariq, M., Nishino, N., Dan, S., Kagechika, H., Yamori, T., Yokoyama, S. and Yoshida, M.:
  “Identification of Cyproheptadine as an Inhibitor of SET Domain Containing Lysine Methyltransferase 7/9 (Set7/9) That Regulates Estrogen-Dependent Transcription.”
  Journal of Medicinal Chemistry 59(8), 3650-3660. (2016).

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