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RIKEN Center for Integrative Medical Sciences (IMS)

Kazuhiko Yamamoto(M.D., Ph.D.) Director: Kazuhiko Yamamoto (M.D., Ph.D.)

At the Center for Integrative Medical Sciences, we aim to elucidate the pathogenesis of human diseases and establish new therapeutic methodologies by conducting cutting-edge research on human genome and immune functions. To that end, we have established four divisions: (1) Division of Genomic Medicine, (2) Division of Human Immunology, (3) Division of Disease Systems Biology, and (4) Division of Cancer Immunology. These groups work together to promote state-of-the-art research.

We apply multi-omics analyses across the hierarchy of genome, gene expressions, proteins, lipids, cells, tissues, and individuals by utilizing computational methods of data analysis, combining statistics and AI technology. We also have established a platform that will allow us to better understand the results obtained in experimental animals and apply them to human immunology research, and to elucidate mechanisms of human pathology using experimental systems such as cell and animal models. Further, we are utilizing these infrastructures to develop next generation research.


List of Organizations

Laboratory for Applied Computational Genomics
Michiel Jan Laurens De Hoon (Ph.D.)
Laboratory for Comprehensive Genomic Analysis
Yasushi Okazaki (M.D., Ph.D.)
RIKEN-IFOM Joint Laboratory for Cancer Genomics
Yasuhiro Murakawa (M.D., Ph.D)
Laboratory for Genotyping Development
Yukihide Momozawa (D.V.M., Ph.D.)
Laboratory for Pharmacogenomics
Taisei Mushiroda (Ph.D.)
Laboratory for Systems Genetics
Yukinori Okada (M.D., Ph.D.)
Laboratory for Retrotransposon Dynamics
Tomoichiro Miyoshi (Ph.D.)
Laboratory for Regulatory Genomics
Chung Chau Hon (Ph.D.)
Laboratory for Autoimmune Diseases
Kazuhiko Yamamoto (M.D., Ph.D)
Laboratory for Human Immunogenetics
Kazuyoshi Ishigaki (M.D., Ph.D.)
Laboratory for Lymphocyte Differentiation
Tomohiro Kurosaki (M.D., Ph.D)
Laboratory for Transcriptional Regulation
Ichiro Taniuchi (M.D., Ph.D)
Laboratory for Immune Cell Systems
Shigeo Koyasu (D.Sc.)
Laboratory for Immune Homeostasis
Taishin Akiyama (Ph.D.)
Laboratory for Immunological Memory
Shiki Takamura (D.V.M., Ph.D.)
Laboratory for Inflammatory Immune Metabolism
Sonia Sharma (Ph.D.)
Laboratory for Developmental Genetics
Haruhiko Koseki (M.D., Ph.D)
Laboratory for Intestinal Ecosystem
Hiroshi Ohno (M.D., Ph.D)
Laboratory for Integrative Genomics
Jun Seita (M.D., Ph.D.)
Laboratory for Mucosal Immunity
Sidonia Fagarasan (M.D., Ph.D)
Laboratory for Gut Homeostasis
Kenya Honda (M.D., Ph.D)
Laboratory for Skin Homeostasis
Masayuki Amagai (M.D., Ph.D)
Laboratory for Tissue Dynamics
Takaharu Okada (Ph.D.)
Laboratory for Metabolomics
Makoto Arita (Ph.D.)
Laboratory for Metabolic Networks
Toshimori Kitami (Ph.D.)
Laboratory for Medical Science Mathematics
Tatsuhiko Tsunoda (Ph.D., Ph.D.)
Laboratory for Cancer Genomics
Hidewaki Nakagawa (M.D., Ph.D)
Laboratory for Immunotherapy
Shin-ichiro Fujii (M.D., Ph.D)
Laboratory for Human Disease Models
Fumihiko Ishikawa (M.D., Ph.D)
Laboratory for Cancer Invasion and Metastasis
Kohei Miyazono (M.D., Ph.D)
Genome Immunobiology RIKEN Hakubi Research Team
Nicholas Parrish (M.D., Ph.D)
Young Chief Investigator Program
Hiroshi Ohno (M.D., Ph.D.)
Drug Discovery Antibody Platform Unit
Kazuhiko Yamamoto (M.D., Ph.D.)
aAVC Drug Translational Unit
Shin-ichiro Fujii (M.D., Ph.D)

Recent Research Results



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Contact Information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama, Kanagawa
230-0045, Japan
Email: ims-web [at] riken.jp