Research Summary

Selected Publications

• 1. Fukuda K, Ito Y, Furuichi Y, Matsui T, Horikawa H, Miyano T, Okada T, van Logtestijn M, Tanaka RJ, Miyawaki A, Amagai M.:
  "Three stepwise pH progressions in stratum corneum for homeostatic maintenance of the skin."
  Nat Commun 15(1): 4062.2024
• 2. Tahara U, Matsui T, Atsugi T, Fukuda K, Terooatea TW, Minoda A, Kubo A, Amagai M.:
  "Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein."
  J Invest Dermatol. 143(12): 2346-55.e10. 2023
• 3. Sekita A, Kawasaki H, Fukushima-Nomura A, Yashiro K, Tanese K, Toshima S, Ashizaki K, Miyai T, Yazaki J, Kobayashi A, Namba S, Naito T, Wang QS, Kawakami E, Seita J, Ohara O, Sakurada K, Okada Y, Amagai M, Koseki H.:
  "Multifaceted analysis of cross-tissue transcriptomes reveals phenotype-endotype associations in atopic dermatitis."
  Nat Commun 14(1): 6133.2023
• 4. Morimoto A, Fukuda K, Ito Y, Tahara U, Sasaki T, Shiohama A, Kawasaki H, Kawakami E, Naganuma T, Arita M, Sasaki H, Koseki H, Matsui T, Amagai M.:
  "Microbiota-Independent Spontaneous Dermatitis Associated with Increased Sebaceous Lipid Production in Tmem79-Deficient Mice."
  J Invest Dermatol 142(11): 2864-72.e6.2022
• 5. Iriki H, Takahashi H, Wada N, Nomura H, Mukai M, Kamata A, Ito H, Yamagami J, Matsui T, Kurebayashi Y, Mise-Omata S, Nishimasu H, Nureki O, Yoshimura A, Hori S, Amagai M.:
  "Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus."
  Proc Natl Acad Sci U.S.A. 118(49):e2026763118. 2021
• 6. Takahashi H, Nomura H, Iriki H, Kubo A, Isami K, Mikami Y, Mukai M, Sasaki T, Yamagami , KudoJ, Ito H, Kamata A, Kurebayashi Y, Yoshida H, Yoshimura A, Sun H, Suematsu M, O’Shea, JJ, Kanno Y, Amagai M.:
  "Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin."
  Sci Immunol 6(64):eabb6444. 2021
• 7. Matsui T, Kadono-Maekubo N, Suzuki Y, Furuichi Y, Shiraga K, Sasaki H, Ishida A, Sonoko Takahashi S, Okada T, Toyooka K, Sharif J, Abe T, Kiyonari H, Tominaga M, Miyawaki A, Amagai M.:
  "A unique mode of keratinocyte death requires intracellular acidification."
  Proc Natl Acad Sci U.S.A. 118(17):e2020722118. 2021
• 8. Someya T, Amagai M.:
  "Toward a new generation of smart skin."
  Nat Nanotechnol 37(4):382-88. 2019.
• 9. Miyamoto A, Lee S, Cooray NF, Lee S, Mori M, Matsuhisa N, Jin H, Yoda L, Yokota T, Itoh A, Sekino M, Kawasaki H, Ebihara T, Amagai M, Someya T.:
  "Inflammation-free, gas-permeable, lightweight, stretchable on-skin electronics with nanomeshes."
  Nat Nanotechnol 12(9):907-13. 2017.
• 10. Yokouchi M, Atsugi T, Logtestijn MV, Tanaka RJ, Kajimura M, Suematsu M, Furuse M, Amagai M, Kubo A.:
  "Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape."
  eLife 5:e19593. 2016.

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