RIKEN Center for Integrative Medical Sciences Laboratory for Integrative Genomics
Team Director: Jun Seita (M.D., Ph.D.)
Research Summary

The goal of our laboratory is to accelerate various researches in the biomedical sciences by combining genomics and other multi-omics with deep learning and machine learning. To achieve this, we are concurrently pursuing research activities that can be broadly classified into three categories: 1) central support activities, 2) strategic collaborative researches, and 3) exploratory research. In particular, by integrating rapidly advancing single cell omics technologies with data-driven science, we aim to elucidate disease mechanisms at high resolution and to pioneer new research areas that will lead to personalized medicine in the future.
Main Research Fields
- Biology
Related Research Fields
- Biological Sciences
Keywords
- Technology Development in Multiomics
- Data-driven science
- Deep Learning
Selected Publications
Papers with an asterisk(*) are based on research conducted outside of RIKEN.
- 1.
Yazaki J, Yamanashi T, Nemoto S, Kobayashi A, Han YW, Hasegawa T, Iwase A, Ishikawa M, Konno R, Imami K, Kawashima Y, Seita J.:
"Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry."
Biol Methods Protoc. 29;9(1):bpae039 (2024) - 2.
Ohta T, Hananoe A, Fukushima-Nomura A, Ashizaki K, Sekita A, Seita J, Kawakami E, Sakurada K, Amagai M, Koseki H, Kawasaki H.:
"Best practices for multimodal clinical data management and integration: An atopic dermatitis research case."
Allergol Int. 73(2):255-263. (2024) - 3.
Sekita A, Kawasaki H, Fukushima-Nomura A, Yashiro K, Tanese K, Toshima S, Ashizaki K, Miyai T, Yazaki J, Kobayashi A, Namba S, Naito T, Wang QS, Kawakami E, Seita J, Ohara O, Sakurada K, Okada Y, Amagai M, Koseki H.:
"Multifaceted analysis of cross-tissue transcriptomes reveals phenotype-endotype associations in atopic dermatitis."
Nat Commun. 2;14(1):6133. (2023) - 4.
Kobayashi M, Wei H, Yamanashi T, Azevedo Portilho N, Cornelius S, Valiente N, Nishida C, Cheng H, Latorre A, Zheng WJ, Kang J, Seita J, Shih DJ, Wu JQ, Yoshimoto M.:
"HSC-independent definitive hematopoiesis persists into adult life."
Cell Rep. 28;42(3):112239. (2023) - 5.
Sato Y, Oguchi A, Fukushima Y, Masuda K, Toriu N, Taniguchi K, Yoshikawa T, Cui X, Kondo M, Hosoi T, Komidori S, Shimizu Y, Fujita H, Jiang L, Kong Y, Yamanashi T, Seita J, Yamamoto T, Toyokuni S, Hamazaki Y, Hattori M, Yoshikai Y, Boor P, Floege J, Kawamoto H, Murakawa Y, Minato N, Yanagita M.:
"CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury."
J Clin Invest. 132(2):e146071. (2022) - 6.
*Travaglini KJ, Nabhan AN, Penland L, Sinha R, Gillich A, Sit RV, Chang S, Conley SD, Mori Y, Seita J, Berry GJ, Shrager JB, Metzger RJ, Kuo CS, Neff N, Weissman IL, Quake SQ, Krasnow MA.:
"A molecular cell atlas of the human lung from single cell RNA sequencing"
Nature 587(7835):619 (2020) - 7.
Yazaki J, Kawashima Y, Ogawa T, Kobayashi A, Okoshi M, Watanabe T, Yoshida S, Kii I, Egami S, Amagai M, Hosoya T, Shiroguchi K, Ohara O.:
"HaloTag-based conjugation of proteins to barcoding-oligonucleotides"
Nucleic Acids Res. 48(2):e8 (2020) - 8.
Kawashima Y, Watanabe E, Umeyama T, Nakajima D, Hattori M, Honda K, Ohara O.:
"Optimization of Data-Independent Acquisition Mass Spectrometry for Deep and Highly Sensitive Proteomic Analysis"
Int J Mol Sci. 20(23) 5932 (2019) - 9.
Kawashima Y, Miyata J, Watanabe T, Shioya J, Arita M, Ohara O.:
"Proteogenomic Analyses of Cellular Lysates Using a Phenol-Guanidinium Thiocyanate Reagent"
J Proteome Res. 18(1), 301-308 (2019) - 10.
Rosental B, Kowarsky M, Seita J, Corey DM, Ishizuka KJ, Palmeri KJ, Chen SY, Sinha R, Okamoto J, Mantalas G, Manni L, Raveh T, Clarke DN, Tsai JM, Newman AM, Neff NF, Nolan GP, Quake SR, Weissman IL, Voskoboynik A.:
"Complex mammalian-like haematopoietic system found in a colonial chordate"
Nature. 564(7736) 425 (2018)
Recent Research Results
Related Links
Lab Members
Principal investigator
- Jun Seita
- Team Director
Core members
- Yongwoon Han
- Research Scientist
- Takaho Endo
- Technical Scientist
- Takashi Watanabe
- Technical Scientist
- Dorothy DeMore Ellis
- Postdoctoral Researcher
- Noriko Yoza
- Expert Technician
- Yoshiki Mochizuki
- Expert Technician
- Tomoko Hasegawa
- Senior Technical Staff
- Clive Steven Barker
- Technical Staff I
- Atsuo Kobayashi
- Technical Staff I
- Fumie Yokoyama
- Technical Staff I
- Juri Shioya
- Technical Staff I
- Reiko Kuwahara
- Technical Staff I
- Takashi Yamanashi
- Student Trainee
Contact Information
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan