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RIKEN Center for Integrative Medical Sciences Laboratory for Integrative Genomics

Team Director: Jun Seita (M.D., Ph.D.)

Research Summary

Jun  Seita(M.D., Ph.D.)

The goal of our laboratory is to accelerate various researches in the biomedical sciences by combining genomics and other multi-omics with deep learning and machine learning. To achieve this, we are concurrently pursuing research activities that can be broadly classified into three categories: 1) central support activities, 2) strategic collaborative researches, and 3) exploratory research. In particular, by integrating rapidly advancing single cell omics technologies with data-driven science, we aim to elucidate disease mechanisms at high resolution and to pioneer new research areas that will lead to personalized medicine in the future.

Main Research Fields

  • Biology

Related Research Fields

  • Biological Sciences

Keywords

  • Technology Development in Multiomics
  • Data-driven science
  • Deep Learning

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1. Yazaki J, Yamanashi T, Nemoto S, Kobayashi A, Han YW, Hasegawa T, Iwase A, Ishikawa M, Konno R, Imami K, Kawashima Y, Seita J.:
    "Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry."
    Biol Methods Protoc. 29;9(1):bpae039 (2024)
  • 2. Ohta T, Hananoe A, Fukushima-Nomura A, Ashizaki K, Sekita A, Seita J, Kawakami E, Sakurada K, Amagai M, Koseki H, Kawasaki H.:
    "Best practices for multimodal clinical data management and integration: An atopic dermatitis research case."
    Allergol Int. 73(2):255-263. (2024)
  • 3. Sekita A, Kawasaki H, Fukushima-Nomura A, Yashiro K, Tanese K, Toshima S, Ashizaki K, Miyai T, Yazaki J, Kobayashi A, Namba S, Naito T, Wang QS, Kawakami E, Seita J, Ohara O, Sakurada K, Okada Y, Amagai M, Koseki H.:
    "Multifaceted analysis of cross-tissue transcriptomes reveals phenotype-endotype associations in atopic dermatitis."
    Nat Commun. 2;14(1):6133. (2023)
  • 4. Kobayashi M, Wei H, Yamanashi T, Azevedo Portilho N, Cornelius S, Valiente N, Nishida C, Cheng H, Latorre A, Zheng WJ, Kang J, Seita J, Shih DJ, Wu JQ, Yoshimoto M.:
    "HSC-independent definitive hematopoiesis persists into adult life."
    Cell Rep. 28;42(3):112239. (2023)
  • 5. Sato Y, Oguchi A, Fukushima Y, Masuda K, Toriu N, Taniguchi K, Yoshikawa T, Cui X, Kondo M, Hosoi T, Komidori S, Shimizu Y, Fujita H, Jiang L, Kong Y, Yamanashi T, Seita J, Yamamoto T, Toyokuni S, Hamazaki Y, Hattori M, Yoshikai Y, Boor P, Floege J, Kawamoto H, Murakawa Y, Minato N, Yanagita M.:
    "CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury."
    J Clin Invest. 132(2):e146071. (2022)
  • 6. *Travaglini KJ, Nabhan AN, Penland L, Sinha R, Gillich A, Sit RV, Chang S, Conley SD, Mori Y, Seita J, Berry GJ, Shrager JB, Metzger RJ, Kuo CS, Neff N, Weissman IL, Quake SQ, Krasnow MA.:
    "A molecular cell atlas of the human lung from single cell RNA sequencing"
    Nature 587(7835):619 (2020)
  • 7. Yazaki J, Kawashima Y, Ogawa T, Kobayashi A, Okoshi M, Watanabe T, Yoshida S, Kii I, Egami S, Amagai M, Hosoya T, Shiroguchi K, Ohara O.:
    "HaloTag-based conjugation of proteins to barcoding-oligonucleotides"
    Nucleic Acids Res. 48(2):e8 (2020)
  • 8. Kawashima Y, Watanabe E, Umeyama T, Nakajima D, Hattori M, Honda K, Ohara O.:
    "Optimization of Data-Independent Acquisition Mass Spectrometry for Deep and Highly Sensitive Proteomic Analysis"
    Int J Mol Sci. 20(23) 5932 (2019)
  • 9. Kawashima Y, Miyata J, Watanabe T, Shioya J, Arita M, Ohara O.:
    "Proteogenomic Analyses of Cellular Lysates Using a Phenol-Guanidinium Thiocyanate Reagent"
    J Proteome Res. 18(1), 301-308 (2019)
  • 10. Rosental B, Kowarsky M, Seita J, Corey DM, Ishizuka KJ, Palmeri KJ, Chen SY, Sinha R, Okamoto J, Mantalas G, Manni L, Raveh T, Clarke DN, Tsai JM, Newman AM, Neff NF, Nolan GP, Quake SR, Weissman IL, Voskoboynik A.:
    "Complex mammalian-like haematopoietic system found in a colonial chordate"
    Nature. 564(7736) 425 (2018)

Recent Research Results

Related Links

Lab Members

Principal investigator

Jun Seita
Team Director

Core members

Yongwoon Han
Research Scientist
Takaho Endo
Technical Scientist
Takashi Watanabe
Technical Scientist
Dorothy DeMore Ellis
Postdoctoral Researcher
Noriko Yoza
Expert Technician
Yoshiki Mochizuki
Expert Technician
Tomoko Hasegawa
Senior Technical Staff
Clive Steven Barker
Technical Staff I
Atsuo Kobayashi
Technical Staff I
Fumie Yokoyama
Technical Staff I
Juri Shioya
Technical Staff I
Reiko Kuwahara
Technical Staff I
Takashi Yamanashi
Student Trainee

Contact Information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan

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