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RIKEN Center for Integrative Medical Sciences Young Chief Investigator Program

Program Director: Kazuhiko Yamamoto (M.D., Ph.D)

Research Summary

Kazuhiko Yamamoto (M.D., Ph.D)

The purpose of the Young Chief Investigator (YCI) program is to provide a career path for young investigators who conduct multidisciplinary research that transcends the existing research areas of medicine, immunology, genomics, informatics, physics, etc. The YCIs are expected to become leaders of independent research in a new area.
The YCI runs an independent research laboratory in terms of funding and research. The laboratory, however, share space, equipment and facilities with a host laboratory in the Center. The YCI will be supported by Advisors from related fields and receive guidance for research, preparation of papers, presentations and obtaining research funding.

Main Research Fields

  • Biology


  • Multidisciplinary
  • Young Investigator
  • Nurture program

Selected Publications

  • 1.Yugi, K. and Kuroda, S.:
    "Metabolism-Centric Trans-Omics"
    Cell Syst. 4(1):19-20. (2017)
  • 2.Bansal K, Yoshida H, Benoist C, Mathis D.:
    "The transcriptional regulator Aire binds to and activates super-enhancers"
    Nat Immunol. 18:263-273. (2017)
  • 3.Fujikawa Y, Yoshida H, Inoue T, Ohbayashi T, Noda K, von Melchner H, Iwasaka T, Shiojima I, Akama TO, Nakamura T.:
    "Latent TGF-β binding protein 2 and 4 have essential overlapping functions in microfibril development"
    Sci Rep. 7:43714. doi: 10.1038/srep43714.(2017)
  • 4.Ikawa T, Masuda K, Endo TA, Endo M, Isono K, Koseki Y, Nakagawa R, Kometani K, Takano J, Agata Y, Katsura Y, Kurosaki T, Vidal M, Koseki H, Kawamoto H.:
    "Conversion of T cells to B cells by inactivation of polycomb-mediated epigenetic suppression of the B-lineage program"
    Genes Dev. 30:2475-2485. (2016)
  • 5.Ikawa T, Masuda K, Huijskens MJ, Satoh R, Kakugawa K, Agata Y, Miyai T, Germeraad WT, Katsura Y, Kawamoto H.:
    "Induced Developmental Arrest of Early Hematopoietic Progenitors Leads to the Generation of Leukocyte Stem Cells"
    Stem Cell Reports. 5:716-27. (2015)
  • 6.Kitami T, Logan DJ, Negri J, Hasaka T, Tolliday NJ, Carpenter AE, Spiegelman BM, Mootha VK.:
    "A chemical screen probing the relationship between mitochondrial content and cell size"
    PLoS ONE 7(3) e33755. (2012)
  • 7.Williams, EG.,* Wu, Y.,* Jha, P., Dubuis, S., Blattmann, P., Argmann, CA., Houten, SM., Amariuta, T., Wolski, W., Zamboni, N., Aebersold, R., and Auwerx, J.
    "Systems proteomics of liver mitochondria function."
    Science. 352(6291). (2016) (*equally contributors)
  • 8.Wu, Y.,* Williams, EG.,*, Dubuis, S., Mottis, A., Jovaisaite, V., Houten, SM., Argmann, CA., Faridi, P., Wolski, W., Kutalik, Z., Zamboni, N., Auwerx, J., and Aebersold, R.
    "Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population."
    Cell. 158(6) :1415-1430, (2014).

Recent Research Results

Related Links

Lab Members

Principal investigator

Kazuhiko Yamamoto
Program Director

Core members

Hideyuki Yoshida
Senior Research Scientist
Azusa Inoue
Senior Research Scientist
Chisayo Kozuka
Special Postdoctoral Researcher
Hailiang Mei
Postdoctoral Researcher
Clive Steven Barker
Technical Staff I
Mami Kumon
Technical Staff II

Contact Information

6F, North Research Building,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-7001
Fax: +81-(0)45-503-7003