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RIKEN Center for Integrative Medical Sciences Precision Immune Regulation RIKEN ECL Research Unit

RIKEN ECL Unit Leader: Naoko Satoh-Takayama (Ph.D.)

Research Summary

 Kazuhiko Yamamoto

By applying spatial analysis to age- and time-dependent immune responses, we aim to elucidate the mechanisms that regulate the immune responses between different organs and how their immune regulation is affected by changes in the microenvironment. The ultimate goal is to understand human pathogenesis based on the results obtained from animal disease models.

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Informatics
  • Biology
  • Immunology


  • Innate lymphoid cells
  • Disease regulation
  • Spatial analysis for immune response

Selected Publications

  • 1. Matsumoto K., Okuyama K., Sidwell T., Yamashita M., Endo T., Satoh-Takayama N., Ohno H., Morio T., Rothenberg EV., and Taniuchi I.:
    "A Bacl11b N797/K variant isolated from an immunodeficient patient inhibits early thymocyte development in mice."
    Frontiers in Immunology. 2024. Doi: 10.3389/fimmu.2024.1363704.
  • 2. Mori A., Ohno H. and Satoh-Takayama N.:
    "Disease pathogenesis and barrier functions regulated by group 3 innate lymphoid cells."
    Seminars in Immunology. 2024. Doi: 10.1007/s00281-024-01000-1
  • 3. Ito A., Akama Y., Satoh-Takayama N., Saito K., Kato T., Kawamoto E., Gaowa A., Park EJ., Takao M., Shimaoka M.:
    "Possible metastatic stage-dependent ILC2 activation induces differential function of MDSCs through IL-13/IL-13Ra1 signaling during the progression of breast cancer lung metastasis."
    Cancers. 14(13): 3267, 2022. doi:10.3390/cancers14133267.
  • 4. Shi Z., Takeuchi T., Nakanishi Y., Kato T., Beck K., Nagata R., Kageyama T., Ito A., Ohno H. and Satoh-Takayama N.:
    "A Japanese Herbal formula, Daikenchuto, alleviates experimental colitis by reshaping microbial profiling and enhancing group 3 innate lymphoid cells."
    Frontiers in Immunology. 13: 903459, 2022. doi:10.3389/fimmu.2022.903459.
  • 5. Akama Y., Park EJ., Satoh-Takayama N., Gaowa A., Ito A., Kawamoto E., Darkwas S., Appiah M.G., Myint PK., Ohno H., Imai H. and Shimaoka M.:
    "Sepsis induces deregulation of IL-13 production and PD-1 expression in lung group 2 innate lymphoid cells."
    Shock. 55: 357-370, 2021. doi: 10.1097/SHK.0000000000001647.
  • 6. Satoh-Takayama N., Kato T., Motomura Y., Kageyama T., Taguchi-Atarashi N., Daitoku-Kinoshita R., Kuroda E., Di Santo JP., Mimuro H., Moro K. and Ohno H.:
    "Bacteria-induced group 2 innate lymphoid cells in the stomach provide immune protection through induction of IgA."
    Immunity. 52: 635-649, 2020. doi:10.1016/j.immuni.2020.03.002.
  • 7. Satoh-Takayama N., Serafini N., Verrier T., Rekiki A., Renauld JC. Frankel G. and Di Santo JP.:
    "CXCR6 controls the functional topography of IL-22 producing intestinal innate lymphoid cells."
    Immunity. 41: 776-788, 2014. doi:10.1016/j.immuni.2014.10.007.
  • 8. Satoh-Takayama N., Lesjean-Pottier S., Sawa S,. Vosshenrich CA., Eberl G. and Di Santo JP.:
    "Lymphotoxin-beta receptor-independent development of intestinal IL-22-producing NKp46+ innate lymphoid cells."
    European Journal of Immunology. 41: 780-6, 2011. doi:10.1002/eji.201040851.
  • 9. Satoh-Takayama N., Lesjean-Pottier S., Vieira P., Sawa S., Eberl G., Vosshenrich CA. and Di Santo JP.:
    "IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subset from Id2-dependent precursors."
    Journal of Experimental Medicine. 207: 273-80, 2010. doi:10.1084/jem.20092029.
  • 10. Satoh-Takayama N., Vosshenrich CA., Lesjean-Pottier S., Sawa S., Lochner M., Rattis F., Mention JJ., Thiam K., Cerf-Bensussan N., Mandelboim O., Eberl G. and Di Santo JP.:
    "Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense."
    Immunity. 29: 958-70, 2008. doi:10.1016/j.immuni.2008.11.001.

Related Links

Lab Members

Principal investigator

Naoko Satoh-Takayama
RIKEN ECL Unit Leader


Position Deadline
Seeking a few Research Scientists or Postdoctoral Researchers (Y24020) Open until filled

Contact Information

North Research Building,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Email: naoko.satoh [at] riken.jp