Research Summary

Selected Publications

• 1. Takeuchi T, Kubota T, Nakanishi Y, Tsugawa H, Suda W, Kwon AT, Yazaki J, Ikeda K, Nemoto S, Mochizuki Y, Kitami T, Yugi K, Mizuno Y, Yamamichi N, Yamazaki T, Takamoto I, Kubota N, Kadowaki T, Arner E, Carninci P, Ohara O, Arita M, Hattori M, Koyasu S, Ohno H.:
  "Gut microbial carbohydrate metabolism contributes to insulin resistance"
  Nature 621, 389-395, 2023
  doi: 10.1038/s41586-023-06466-x.
• 2. Takeuchi T, Kameyama K, Miyauchi E, Nakanishi Y, Kanaya T, Fujii T, Kato T, Sasaki T, Tachibana N, Negishi H, Matsui M, Ohno H.:
  "Fatty acid overproduction by gut commensal microbiota exacerbates obesity"
  Cell Metab 35, 361-375.e9, 2023.
  doi: 10.1016/j.cmet.2022.12.013.
• 3. Nagata N, Takeuchi T, Masuoka H, Aoki R, Ishikane M, Iwamoto N, Sugiyama M, Suda W, Nakanishi Y, Terada-Hirashima J, Kimura M, Nishijima T, Inooka H, Miyoshi-Akiyama T, Kojima Y, Shimokawa C, Hisaeda H, Zhang F, Yeoh YK, Ng SC, Uemura N, Itoi T, Mizokami M, Kawai T, Sugiyama H, Ohmagari N, Ohno H.:
  "Human gut microbiota and its metabolites impact immune responses in COVID-19 and its complications"
  Gastroenterology 164, 272-288, 2023.
  doi: 10.1053/j.gastro.2022.09.024.
• 4. Takeuchi T, Miyauchi E, Kanaya T, Kato T, Nakanishi Y, Watanabe T, Kitami T, Taida T, Sasaki T, Negishi H, Shimamoto S, Matsuyama A, Kimura I, Williams IR, Ohara O, Ohno H.:
  "Acetate differentially regulates IgA reactivity to commensal bacteria"
  Nature 595, 560-564, 2021.
  doi: 10.1038/s41586-021-03727-5
• 5. Miyauchi E, Kim S-W, Suda W, Kawasumi M, Onawa S, Taguchi-Atarashi N, Morita M, Taylor TD, Hattori M, Ohno H.:
  "Gut microbes act in concert to exacerbate inflammation in spinal cords."
  Nature 585, 102-106, 2020.
  doi: 10.1038/s41586-020-2634-9.
• 6. Satoh-Takayama N, Kato T, Motomura Y, Kageyama T, Taguchi-Atarashi N, Kinoshita-Daitoku R, Kuroda E, Di Santo JP, Mimuro H, Moro K, Ohno H.:
  "Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA."
  Immunity 52, 635-649.e4, 2020.
  doi: 10.1016/j.immuni.2020.03.002.
• 7. Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano, S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I. R., Ohno, H.:
  "Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-B signaling."
  J. Exp. Med. 215, 501-519, 2018.
  doi: 10.1084/jem.20160659
• 8. Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams IR, Kiyono H, Ohno H.:
  "IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake. "
  J Exp Med. 214, 1607-1618, 2017.
  doi: 10.1084/jem.20160770.
• 9. Shimokawa, C., Kanaya, T., Hachisuka, M., Ishiwata, K., Hisaeda, H., Kurashima, Y., Kiyono, H., Yoshimoto, T., Kaisho, T., Ohno, H.:
  "Mast cells are crucial for induction of group 2 innate lymphoid cells and clearance of helminth infections."
  Immunity 46, 863-874, 2017.
  doi: 10.1016/j.immuni.2017.04.017.
• 10. Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., Takahashi, M., Fukuda, N. N., Murakami, S., Miyauchi, E., Hino, S., Atarashi, K., Onawa, S., Fujimura, Y., Lockett, T., Clarke, J. M., Topping, D. L., Tomita, M., Hori, S., Ohara, O., Morita, T., Koseki, H., Kikuchi, J., Honda, K., Hase, K., Ohno, H.:
  "Commensal microbe-derived butyrate induces colonic regulatory T cells."
  Nature 504, 446-450, 2013.
  doi: 10.1038/nature12721.

Recent Research Results

• 

  May 21, 2025
  Gut bacteria and acetate, a great combination for weight loss

• 

  Feb. 21, 2025
  Infant gut bacteria and food allergies: the good, the bad, and the ugly

• 

  Sep. 30, 2024
  Proteins in meat, milk, and other foods suppress gut tumors

• 

  Mar. 15, 2024
  Gut bacteria important for overcoming milk allergy

• 

  Sep. 1, 2023
  Bacteria treatment reduces insulin resistance, protects against diabetes

• 

  Apr. 18, 2023
  A gut microbe that can exacerbate obesity

• 

  Aug. 22, 2022
  How a Japanese herbal medicine protects the gut against inflammatory bowel disease

• 

  Jul. 20, 2021
  A simple compound to control complex gut microbes

• 

  Aug. 27, 2020
  Tag team gut bacteria worsen symptoms of multiple sclerosis

• 

  Jun. 26, 2020
  Friendly bacteria fight stomach ulcers

• 

  Jul. 3, 2019
  Innate immune responses to high-fat diets lead to obesity

• 

  Aug. 10, 2017
  The mast-er of worm defense

• Jan. 10, 2014
  Friends in low places preserve gut health

• 

  Nov. 14, 2013
  Fatty acid produced by gut bacteria boosts the immune system

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