RIKEN Center for Integrative Medical Sciences Laboratory for Comprehensive Genomic Analysis
Team Leader: Yasushi Okazaki (M.D., Ph.D.)
Research Summary

This facility will implement and standardize next generation sequencing applications, with particular focus on analysis of transcriptome, gene regulation network, ncRNA. The platform will provide highly standardized technological and analytical services to the users, in order to minimize the time from sample to data and to deliver high quality data.
Main Research Fields
- Medicine, Dentistry & Pharmacy
Related Research Fields
- Informatics
- Biology
Keywords
- Mitochondrial Disease
- Bioinformatics
- Inherited Disease
Selected Publications
Papers with an asterisk(*) are based on research conducted outside of RIKEN.
- 1.
Ozaki K, Irioka T, Uchihara T, Yamada A,Nakamura A,Majima T,Igarashi S, Shintaku H,Yakeishi M, Tsuura Y, Okazaki Y,Ishikawa K, Yokota T,
"Neuropathology of SCA34 showing widespread oligodendroglial pathology with vacuolar white matter degeneration: a case study
Acta Neuropathol Commun. 9(1)172(2021) doi: 10.1186/s40478-021-01272-w. - 2.
Yasuoka Y, Taira M
"LIM homeodomain proteins and associated partners: Then and now
Current Topics in Developmental Biology. 145,113-166(2021) doi: 10.1016/bs.ctdb.2021.04.003. - 3.
Inaba A, Arinaga A, Tanaka K, Endo T, Hayatsu N, Okazaki Y, Yamane T, Oishi Y, Imai H, Iwatsuki K
"Interleukin-4 Promotes Tuft Cell Differentiation and Acetylcholine Production in Intestinal Organoids of Non-Human Primate"
Int J Mol Sci. 22(15)7921(2021) doi: 10.3390/ijms22157921. - 4.
Takata S, Amitani H, Endo M, Yuki H, Ramilowski J, Severin J, Manabe R, Watanabe T, Ozaki K, Kaneko A, Kajita H, Fujiki S, Sato K, Honma T, Uchida N, Fukami T, Okazaki Y, Ohara O, Shultz L, Yamada M, Taniguchi S, Vyas P, deHoon M, Momozawa Y, Ishikawa F,
"Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia"
Nature Cancer 2,340–356 (2021) https://doi.org/10.1038/s43018-021-00177-w - 5.
Grapotte M, Saraswat M, Bessière C, Menichelli C, Ramilowski J, Severin J, Hayashizaki Y, Itoh M, Tagami M, Murata M, Kojima-Ishiyama M, Noma S, Noguchi S, Kasukawa T, Hasegawa A, Suzuki H, Nishiyori-Sueki H, C.Frith M, FANTOM consortium, Chatelain C, Carninci P, deHoon M, W.Wasserman W, Bréhélin L, Lecellier C,
"Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network"
Nat Commun. 12(1)3297(2021) doi: 10.1038/s41467-021-23143-7. - 6.
Ducoli L,Agrawal S,Hon C, Ramilowski J,Sibler E, Tagami M, Itoh M, Kondo N, Abugessaisa I, Hasegawa A, Kasukawa T, Suzuki H, Carninci P, Shin J, J.L.deHoon M, Detmar M,
"The choice of negative control antisense oligonucleotides dramatically impacts downstream analysis depending on the cellular background"
BMC Genomic Data 22,33 (2021) doi:10.1186/s12863-021-00992-1. - 7.
*Saito K, Zhang Q, Yang H, Yamatani K, Ai T, Ruvolo V, Baran N, Cai T, Ma H, Jacamo R, Kuruvilla V, Imoto J, Kinjo S, Ikeo K, Moriya K, Suzuki K, Miida T, Kim Y-M, Vellano C P, Andreeff M, Marszalek J R, Tabe Y, Konopleva M,
"Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition"
Blood Adv. 5(20)4233-4255(2021) doi: 10.1182/bloodadvances.2020003661. - 8.
Ito Y, Terao Y, Noma S, Tagami M, Yoshida E, Hayashizaki Y, Itoh M, Kawaji H,
"Nanopore sequencing reveals TACC2 locus complexity and diversity of isoforms transcribed from an intronic promoter"
Sci Rep,11,9355(2021) doi: 10.1038/s41598-021-88018-9 - 9.
*Yamamura Y, Furuichi K, Murakawa Y, Hirabayashi S, Yoshihara M, Sako K, Kitajima S, Toyama T, Iwata Y, Sakai N, Hosomichi K, Murphy P.M, Tajima A, Okita K, Osafune K, Kaneko S, Wada T,
"Identification of candidate PAX2-regulated genes implicated in human kidney development"
Sci Rep, 11, 9123(2021) doi: 10.1038/s41598-021-88743-1 - 10.
Yasuoka Y, Matsumoto M, Yagi K, Okazaki Y
"Evolutionary History of GLIS genes illuminates their Roles in Cell Reprogramming and Ciliogenesis"
Mol Biol Evol.37(1),100-109(2020) doi: 10.1093/molbev/msz205.
Related Links
Lab Members
Principal investigator
- Yasushi Okazaki
- Team Leader
Core members
- Kokoro Ozaki
- Deputy Team Leader
- Riichiroh Manabe
- Senior Research Scientist
- Yuuri Yasuoka
- Research Scientist
- Norihito Hayatsu
- Research Scientist
- Hiroko Hagiwara
- Research Scientist
- Tomoko Hirata
- Technical Scientist
- Yumiko Yamamoto
- Technical Scientist
- Ryota Teramoto
- Special Postdoctoral Researcher
- Michihira Tagami
- Expert Technician
- Tsugumi Kawashima
- Senior Technical Staff
- Shohei Noma
- Senior Technical Staff
- Chitose Takahashi
- Technical Staff I
- Hiroko Kinoshita
- Technical Staff I
- Ayaka Tokumura
- Technical Staff I
Contact Information
West Research Building 4F W403
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9237
Fax: +81-(0)45-503-9216
Email: LSA-support [at] riken.jp