RIKEN Center for Integrative Medical Sciences Laboratory for Infectious Diseases and Immunology
Team Director: Kosuke Miyauchi (Ph.D.)
Research Summary

We aim to elucidate the pathogenesis of infectious diseases caused by viruses and other pathogenic microorganisms and to develop therapeutic agents and vaccines. We will conduct basic research to study the immune response against pathogens, and to identify biomarkers and target molecules for therapeutic agents. We will contribute to the development of next-generation infectious disease research to prepare for future pandemics.
Main Research Fields
- Medicine, Dentistry & Pharmacy
Related Research Fields
- Biological Sciences
- Biology
- Virology
- Immunology
Keywords
- Immune mechanisms against virus infections
- Pathogenesis in infectious diseases
- Infectious disease treatment
- Vaccine
- COVID19
Selected Publications
- 1.
Takeshita M, Fukuyama Y, Kamada K, Matsumoto T, Makino-Okamura C, Lin Q, Sakuma M, Kawahara E, Yamazaki I, Uchikubo-Kamo T, Tomabechi Y, Hanada K, Hisano T, Moriyama S, Takahashi Y, Ito M, Imai M, Maemura T, Furusawa Y, Yamayoshi S, Kawaoka Y, Shirouzu M, Ishi M, Saya H, Kondo Y, Kaneko Y, Suzuki K, Fukunaga K, Takeuchi T, Keio Donner Project.
"Potent neutralizing broad-spectrum antibody against SARS-CoV-2 generated from dual-antigen-specific B cells from convalescents."
iScience 26, 106955 (2023). - 2.
Nihei Y, Higashiyama M, Miyauchi K, Haniuda K, Suzuki Y, Kubo M, Kitamura D.
"Subcutaneus immunization with zymosan generates mucosal igA-eliciting memory and protects mice from heterologous influenza virus infection."
Int Immunol 35, 277-386 (2023) - 3.
Takeshita M, Fukuyama H, Kamada K, Matsumoto T, Makino-Okamura C, Uchikubo-Kamo T, Tomabechi Y, Hanada K, Moriyama S, Takahashi Y, Ishigaki H, Nakayama M, Nguyen CT, Kitagawa Y, Itoh Y, Imai M, Maemura T, Furusawa Y, Ueki H, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Kawaoka Y, Shirouzu M, Ishii M, Saya H, Kondo Y, Kaneko Y, Suzuki K, Fukunaga K, Takeuchi T.
"SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models."
iScience 25, 105596 (2022). - 4.
Miyauchi K, Adachi Y, Tonouchi K, Yajima T, Harada Y, Fukuyama H, Deno S, Iwakura Y, Yoshimura A, Hasegawa H, Yugi K, Fujii S, Ohara O, Takahashi Y, Kubo M.
"Influenza virus infection expands the breadth of antibody responses through IL-4 signal in B cells."
Nat Commun 12, 3789 (2021) - 5.
Sarkander J, Hojyo S, Mursell M, Yamasaki Y, Wu T, Tumes DJ, Miyauchi K, Tran CL, Zhu J, Lohning M, Hutloff A, Mashreghi M, Kubo M, Radbruch A, Tokoyoda K.
"Enhanced Cell Division Is Required for the Generation of Memory CD4 T Cells to Migrate Into Their Proper Location."
Front Immunol 10, 3113 (2020) - 6.
Sato R, Makino-Okamura C, Lin Q, Wang M, Shoemaker JE, Kurosaki T, Fukuyama H.
"Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine."
Int Immunol 32, 499-507 (2020)
Lab Members
Principal investigator
- Kosuke Miyauchi
- Team Director
Core members
- Haruhiko Koseki
- Senior Research Scientist
- Hiroshi Ohno
- Senior Research Scientist
- Shin-ichiro Fujii
- Senior Research Scientist
- Masashi Matsuda
- Senior Technical Scientist
- Tomoyuki Ishikura
- Expert Technician
- Yusuke Iizuka
- Expert Technician
- Machie Sakuma
- Technical Staff I
- Midori Unno
- Technical Staff I
- Akiko Sugimoto
- Technical Staff I
- Chieko Tezuka
- Technical Staff I
- Hidehiro Fukuyama
- Senior Visiting Scientist
- Chieko Okamura
- Senior Visiting Scientist
Contact Information
West Research Building,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Email: kosuke.miyauchi [at] riken.jp