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RIKEN Center for Integrative Medical Sciences Infectious Diseases Research Unit

Unit Leader: Haruhiko Koseki (M.D., Ph.D)

Research Summary

Haruhiko Koseki (M.D., Ph.D)

Elucidate the pathogenesis of infectious diseases caused by highly pathogenic microorganisms and develop therapeutic agents and vaccines. Identify biomarkers that contribute to the prevention of serious diseases and target molecules that lead to the development of therapeutic agents and vaccines by carrying out research on the pathogenicity of pathogens and host immune responses. Conduct basic research to prepare for pandemics such as COVID-19 and contribute to the development of next-generation infectious disease research.

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Immunology
  • Virology

Keywords

  • Vaccine
  • Infectious disease therapy
  • pathogenic mechanism
  • COVID-19

Selected Publications

  • 1. Miyauchi K, Adachi Y, Tonouchi K, Yajima T, Harada Y, Fukuyama H, Deno S, Iwakura Y, Yoshimura A, Hasegawa H, Yugi K, Fujii S, Ohara O, Takahashi Y, Kubo M.:
    "Influenza virus infection expands the breadth of antibody responses through IL-4 signal in B cells."
    Nat Commun 12, 3789 (2021)
  • 2. Tamaura M, Satoh-Takayama N, Tsumura M, Sasaki T, Goda S, Kageyama T, Hayakawa S, Kimura S, Asano T, Nakayama M, Koseki H, Ohara O, Okada S, Ohno H, Kobayashi M.:
    "Human gain-of-function STAT1 mutation disturbs IL-17 immunity in mice."
    Int Immunol 32, 259-272 (2020)
  • 3. Sarkander J, Hojyo S, Mursell M, Yamasaki Y, Wu T, Tumes DJ, Miyauchi K, Tran CL, Zhu J, Lohning M, Hutloff A, Mashreghi M, Kubo M, Radbruch A, Tokoyoda K.:
    "Enhanced Cell Division Is Required for the Generation of Memory CD4 T Cells to Migrate Into Their Proper Location."
    Front Immunol 10, 3113 (2020)
  • 4. Fukuyama H, Shinnakasu R, Kurosaki T.:
    "Influenza vaccination strategies targeting the hemagglutinin stem region."
    Immunol Rev 296, 132-141 (2020)
  • 5. Sato R, Makino-Okamura C, Lin Q, Wang M, Shoemaker JE, Kurosaki T, Fukuyama H.:
    "Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine."
    Int Immunol 32, 499-507 (2020)
  • 6. Miyauchi E, Kim S-W, Suda W, Kawasumi M, Onawa S, Taguchi-Atarashi N, Morita M, Taylor TD, Hattori M, Ohno H.:
    "Gut microbes act in concert to exacerbate inflammation in spinal cords."
    Nature 585, 102-106 (2020)
  • 7. Satoh-Takayama N, Kato T, Motomura Y, Kageyama T, Taguchi-Atarashi N, Kinoshita-Daitoku R, Kuroda E, Di Santo JP, Mimuro H, Moro K, Ohno H.:
    "Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA."
    Immunity 52, 635-649.e4 (2020)
  • 8. Takamura S, Kato S, Motozono C, Shimaoka T, Ueha S, Matsuo K, Miyauchi K, Masumoto T,Katsushima A, Nakayama T, Tomura M, Matsushima K, Kubo M, Miyazawa M.:
    "Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung."
    J Exp Med 216, 2736-2747 (2019)
  • 9. Matsuda M, Ono R, Iyoda T, Endo T, Iwasaki M, Tomizawa-Murasawa M, Saito Y, Kaneko A, Shimizu K, Yamada D, Ogonuki N, Watanabe T, Nakayama M, Koseki Y, Kezuka-Shiotani F, Hasegawa T, Yabe H, Kato S, Ogura A, Shultz LD, Ohara O, Taniguchi M, Koseki H, Fujii SI, Ishikawa F.:
    "Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice."
    Life Sci Alliance 2, e201800195 (2019)
  • 10. Ono R, Watanabe T, Kawakami E, Iwasaki M, Tomizawa-Murasawa M, Matsuda M, Najima Y, Takagi S, Fujiki S, Sato R, Mochizuki Y, Yoshida H, Sato K, Yabe H, Kato S, Saito Y, Taniguchi S, Shultz LD, Ohara O, Amagai M, Koseki H, Ishikawa F.:
    "Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model."
    EBioMedicine 41:584-596 (2019)

Lab Members

Principal investigator

Haruhiko Koseki
Unit Leader

Core members

Hiroshi Ohno
Senior Scientist
Hidehiro Fukuyama
Research Scientist
Kosuke Miyauchi
Research Scientist

Contact Information

North Research Building,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Email: haruhiko.koseki [at] riken.jp

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