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RIKEN Center for Integrative Medical Sciences Laboratory for Infectious Diseases and Immunology

Team Leader: Kosuke Miyauchi (Ph.D.)

Research Summary

Kosuke Miyauchi

We aim to elucidate the pathogenesis of infectious diseases caused by viruses and other pathogenic microorganisms and to develop therapeutic agents and vaccines. We will conduct basic research to study the immune response against pathogens, and to identify biomarkers and target molecules for therapeutic agents. We will contribute to the development of next-generation infectious disease research to prepare for future pandemics.

Main Research Fields

  • Medicine, Dentistry & Pharmacy

Related Research Fields

  • Biological Sciences
  • Biology
  • Virology
  • Immunology

Keywords

  • Immune mechanisms against virus infections
  • Pathogenesis in infectious diseases
  • Infectious disease treatment
  • Vaccine
  • COVID19

Selected Publications

  • 1. Takeshita M, Fukuyama Y, Kamada K, Matsumoto T, Makino-Okamura C, Lin Q, Sakuma M, Kawahara E, Yamazaki I, Uchikubo-Kamo T, Tomabechi Y, Hanada K, Hisano T, Moriyama S, Takahashi Y, Ito M, Imai M, Maemura T, Furusawa Y, Yamayoshi S, Kawaoka Y, Shirouzu M, Ishi M, Saya H, Kondo Y, Kaneko Y, Suzuki K, Fukunaga K, Takeuchi T, Keio Donner Project.
    "Potent neutralizing broad-spectrum antibody against SARS-CoV-2 generated from dual-antigen-specific B cells from convalescents."
    iScience 26, 106955 (2023).
  • 2. Nihei Y, Higashiyama M, Miyauchi K, Haniuda K, Suzuki Y, Kubo M, Kitamura D.
    "Subcutaneus immunization with zymosan generates mucosal igA-eliciting memory and protects mice from heterologous influenza virus infection."
    Int Immunol 35, 277-386 (2023)
  • 3. Takeshita M, Fukuyama H, Kamada K, Matsumoto T, Makino-Okamura C, Uchikubo-Kamo T, Tomabechi Y, Hanada K, Moriyama S, Takahashi Y, Ishigaki H, Nakayama M, Nguyen CT, Kitagawa Y, Itoh Y, Imai M, Maemura T, Furusawa Y, Ueki H, Iwatsuki-Horimoto K, Ito M, Yamayoshi S, Kawaoka Y, Shirouzu M, Ishii M, Saya H, Kondo Y, Kaneko Y, Suzuki K, Fukunaga K, Takeuchi T.
    "SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models."
    iScience 25, 105596 (2022).
  • 4. Miyauchi K, Adachi Y, Tonouchi K, Yajima T, Harada Y, Fukuyama H, Deno S, Iwakura Y, Yoshimura A, Hasegawa H, Yugi K, Fujii S, Ohara O, Takahashi Y, Kubo M.
    "Influenza virus infection expands the breadth of antibody responses through IL-4 signal in B cells."
    Nat Commun 12, 3789 (2021)
  • 5. Sarkander J, Hojyo S, Mursell M, Yamasaki Y, Wu T, Tumes DJ, Miyauchi K, Tran CL, Zhu J, Lohning M, Hutloff A, Mashreghi M, Kubo M, Radbruch A, Tokoyoda K.
    "Enhanced Cell Division Is Required for the Generation of Memory CD4 T Cells to Migrate Into Their Proper Location."
    Front Immunol 10, 3113 (2020)
  • 6. Sato R, Makino-Okamura C, Lin Q, Wang M, Shoemaker JE, Kurosaki T, Fukuyama H.
    "Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine."
    Int Immunol 32, 499-507 (2020)

Lab Members

Principal investigator

Kosuke Miyauchi
Team Leader

Core members

Haruhiko Koseki
Senior Research Scientist
Hiroshi Ohno
Senior Research Scientist
Shin-ichiro Fujii
Senior Research Scientist
Masashi Matsuda
Senior Technical Scientist
Tomoyuki Ishikura
Expert Technician
Yusuke Iizuka
Expert Technician
Machie Sakuma
Technical Staff I
Midori Unno
Technical Staff I
Akiko Sugimoto
Technical Staff I
Chieko Tezuka
Technical Staff I
Hidehiro Fukuyama
Senior Visiting Scientist
Chieko Okamura
Senior Visiting Scientist

Contact Information

West Research Building,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Email: kosuke.miyauchi [at] riken.jp

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