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RIKEN Center for Integrative Medical Sciences Laboratory for Retrotransposon Dynamics

Team Leader: Tomoichiro Miyoshi (Ph.D.)

Research Summary

Tomoichiro Miyoshi

Retrotransposons are driving forces in genome evolution; however, their activities can cause genetic instability that leads to various diseases. Our group focuses on (1) the dynamic regulation of how mammalian retrotransposons mobilize in our genome, and (2) the mechanisms of aging and immune responses that retrotransposons facilitate. In the future, we aim to establish techniques to control the retrotransposon activities, thereby developing methods to suppress disease-associated phenotypes induced by retrotransposons.

Main Research Fields

  • Biological Sciences
  • Biology

Related Research Fields

  • Medicine, Dentistry & Pharmacy
  • Genome biology
  • Genetics
  • Molecular biology


  • Genome
  • Retrotransposon
  • DNA repair
  • Senescence
  • Innate immunity

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1. *Luqman-Fatah A. and Miyoshi T.:
    "Human LINE-1 retrotransposons: impacts on the genome and regulation by host factors."
    Genes Genet Syst. 98: 121-154 (2023).
  • 2. Luqman-Fatah A., Watanabe Y., Uno K., Ishikawa F., Moran J.V., and Miyoshi T.:
    "The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction."
    Nature Communications. 14: 203 DOI: 10.1038/s41467-022-35757-6 (2023).
  • 3. *Yamamoto I., Nakaoka H., Takikawa M., Tashiro S., Kanoh J., Miyoshi T., and Ishikawa F.:
    "Fission yeast Stn1 maintains stability of repetitive DNA at subtelomere and ribosomal DNA regions."
    Nucleic Acids Res. 49: 10465-10476 (2021).
  • 4. *Miyoshi T., Makino T., and Moran J.V.:
    "Poly(ADP-ribose) polymerase 2 recruits replication protein A to sites of LINE-1 integration to facilitate retrotransposition."
    Molecular Cell. 75: 1286-1298 (2019).
  • 5. *Kopera H.C., Flasch D.A., Nakamura M., Miyoshi T., Doucet A.J., and Moran J.V.:
    "LEAP: L1 Element Amplification Protocol."
    Methods Mol. Biol. 1400: 339-355 (2016).
  • 6. *Doucet A.J., Wilusz J.E., Miyoshi T., Liu Y., and Moran J.V.:
    "A 3’ poly(A) tract is required for LINE-1 retrotransposition."
    Molecular Cell. 60: 728-741 (2015).
  • 7. *Miyoshi T., Ito M., and Ohta K.:
    "Spatiotemporal regulation of meiotic recombination by Liaisonin."
    Bioarchitecture. 3: 20-24 (2012)
  • 8. *Miyoshi T., Ito M., Kugou K., Yamada S., Furuichi M., Oda A., Yamada T., Hirota K., Masai H., and Ohta K.:
    "A central coupler for recombination initiation linking chromosome architecture to S-phase checkpoint."
    Molecular Cell. 47: 722-733 (2012).
  • 9. *Hirota K., Miyoshi T., Kugou K., Hoffman C.S., Shibata T., and Ohta K.:
    "Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs."
    Nature. 456, 130-134 (2009).
  • 10. *Miyoshi T., Kanoh J., Saito M., and Ishikawa F.:
    "Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length."
    Science. 320: 1341-1344 (2008).

Related Links

Lab Members

Principal investigator

Tomoichiro Miyoshi
Team Leader

Core members

Ahmad Luqman Bin Abdul Fatah
Postdoctoral Researcher
Kei Nishimori
Junior Research Associate
Yukiko Fumoto
Technical Staff I


Position Deadline
Seeking Research Scientists or Postdoctoral Researcheres (IMS209-2302) Open until filled

Contact Information

East Research Bld. 4F,
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama, Kanagawa,
230-0045, Japan
Email: tomoichiro.miyoshi [at] riken.jp