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RIKEN Center for Integrative Medical Sciences Laboratory for Lymphocyte Differentiation

Team Director: Tomohiro Kurosaki (M.D., Ph.D)

Research Summary

Tomohiro Kurosaki(M.D., Ph.D)

Memory humoral responses are typically more rapid, have a greater magnitude, and consist of antibodies of higher affinity than in the primary response. Our laboratory has now focused on clarifying the functional characterization of memory B cells and memory T cells and on revealing the mechanisms underlying the robustness of memory antibody responses.

Main Research Fields

  • Biology

Related Research Fields

  • Medicine, Dentistry & Pharmacy

Keywords

  • Immunological tolerance, autoimmunity
  • Lymphocyte
  • Immunological memory
  • Antibody

Selected Publications

  • 1.Inoue T, Shinnakasu R, Ise W, Kawai C, Egawa T, Kurosaki T.:
    "The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help"
    J Exp Med (in press, 2017)
  • 2.Igarashi K, Kurosaki T, Roychoudhuri R.:
    "BACH transcription factors in innate and adaptive immunity"
    Nat Rev Immunol 17, 437-450 (2017)
  • 3.Shinnakasu, R., Inoue, T., Kometani, K., Moriyama, S., Adachi, Y., Nakayama, M., Takahashi, Y., Fukuyama, H., Okada, T.,Kurosaki, T.:
    "Regulated selection of germinal center cells into the memory B cell compartment"
    Nat Immunol 17, 861-869 (2016)
  • 4.Inoue, T., Morita, M., Hijikata, A., Fukuda-Yuzawa, Y., Adachi, S., Isono, K., Ikawa, T., Kawamoto, H., Koseki, H., Natsume, T., Fukao, T., Ohara, O., Yamamoto, T., Kurosaki, T.:
    "CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability"
    J Exp Med 212, 1465-1479 (2015)
  • 5.Shinohara, H., Behar, M., Inoue, K., Hiroshima, M., Yasuda, T., Nagashima, T., Kimura, S., Sanjo, H., Maeda, S., Yumoto, N., Ki, Sewon, Akira, S., Sako, Y., *Hoffmann, A., *Kurosaki, T., *Okada-Hatakeyama, M.:
    "Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF-κB Activation. (*co-corresponding authors)"
    Science 344, 760-764 (2014)
  • 6.Ise, W., Inoue, T., McLachlan, J.B., Kometani, K., Kubo, M., Okada, T. Kurosaki, T.:
    "Memory B cells contribute to rapid Bcl6 expression by memory TFH cells"
    Proc. Natl. Acad. U.S.A. 111, 11792-11797 (2014)
  • 7.Matsumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nutt, S.L., Sakaguchi, S., Takeda, K., Kurosaki, T., Baba, Y.:
    "Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation"
    Immunity 41, 1040-1051 (2014)
  • 8.Kometani, K., Nakagawa, R., Shinnakasu, R., Kaji, T., Rybouchkin, A., Moriyama, S., Furukawa, K., Koseki, H., Takemori, T. and Kurosaki, T.:
    "Repression of the Transcription Factor Bach2 Contributes to Predisposition of IgG1 Memory B Cells toward Plasma Cell Differentiation"
    Immunity 39, 136-147 (2013)
  • 9.Sasaki, Y., Sano, S., Nakahara, M., Murata, S., Kometani, K., Aiba, Y., Sakamoto, S., Watanabe, Y., Tanaka, K., Kurosaki, T., and Iwai, K.:
    "Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells"
    EMBO J 32, 2463-2476 (2013)
  • 10.Capietto, A.H., Kim, S., Sanford, D.E., Liehan, D.C., Hikida, M., Kurosaki, T., Novack, D.V. and Faccio, R.:
    "Downregulation of PLCγ2/β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer"
    J. Exp. Med. 210, 2257-2271 (2013)

Recent Research Results

Related Links

Lab Members

Principal investigator

Tomohiro Kurosaki
Team Director

Core members

Keiko Fujisaki
Postdoctoral Researcher
Yoshimasa Takahashi
Visiting Scientist
Takeshi Inoue
Visiting Scientist
Takuya Koike
Visiting Scientist

Contact Information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-7019
Email: tomohiro.kurosaki [at] riken.jp

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