研究概要

主要論文

• 1.Inoue T, Shinnakasu R, Ise W, Kawai C, Egawa T, Kurosaki T.:
  "The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help"
  J Exp Med (in press, 2017)
  
• 2.Igarashi K, Kurosaki T, Roychoudhuri R.:
  "BACH transcription factors in innate and adaptive immunity"
  Nat Rev Immunol 17, 437-450 (2017)
  
• 3.Shinnakasu, R., Inoue, T., Kometani, K., Moriyama, S., Adachi, Y., Nakayama, M., Takahashi, Y., Fukuyama, H., Okada, T.,Kurosaki, T.:
  "Regulated selection of germinal center cells into the memory B cell compartment"
  Nat Immunol 17, 861-869 (2016)
  
• 4.Inoue, T., Morita, M., Hijikata, A., Fukuda-Yuzawa, Y., Adachi, S., Isono, K., Ikawa, T., Kawamoto, H., Koseki, H., Natsume, T., Fukao, T., Ohara, O., Yamamoto, T., Kurosaki, T.:
  "CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability"
  J Exp Med 212, 1465-1479 (2015)
  
• 5.Shinohara, H., Behar, M., Inoue, K., Hiroshima, M., Yasuda, T., Nagashima, T., Kimura, S., Sanjo, H., Maeda, S., Yumoto, N., Ki, Sewon, Akira, S., Sako, Y., *Hoffmann, A., *Kurosaki, T., *Okada-Hatakeyama, M.:
  "Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF-κB Activation. (*co-corresponding authors)"
  Science 344, 760-764 (2014)
  
• 6.Ise, W., Inoue, T., McLachlan, J.B., Kometani, K., Kubo, M., Okada, T. Kurosaki, T.:
  "Memory B cells contribute to rapid Bcl6 expression by memory TFH cells"
  Proc. Natl. Acad. U.S.A. 111, 11792-11797 (2014)
  
• 7.Matsumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nutt, S.L., Sakaguchi, S., Takeda, K., Kurosaki, T., Baba, Y.:
  "Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation"
  Immunity 41, 1040-1051 (2014)
  
• 8.Kometani, K., Nakagawa, R., Shinnakasu, R., Kaji, T., Rybouchkin, A., Moriyama, S., Furukawa, K., Koseki, H., Takemori, T. and Kurosaki, T.:
  "Repression of the Transcription Factor Bach2 Contributes to Predisposition of IgG1 Memory B Cells toward Plasma Cell Differentiation"
  Immunity 39, 136-147 (2013)
  
• 9.Sasaki, Y., Sano, S., Nakahara, M., Murata, S., Kometani, K., Aiba, Y., Sakamoto, S., Watanabe, Y., Tanaka, K., Kurosaki, T., and Iwai, K.:
  "Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells"
  EMBO J 32, 2463-2476 (2013)
  
• 10.Capietto, A.H., Kim, S., Sanford, D.E., Liehan, D.C., Hikida, M., Kurosaki, T., Novack, D.V. and Faccio, R.:
  "Downregulation of PLCγ2/β-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer"
  J. Exp. Med. 210, 2257-2271 (2013)
  

研究成果（プレスリリース）

• 

  2022年12月15日
  抗体を作り続ける長寿命細胞を発見

• 

  2018年4月18日
  ウイルス感染防御に必須の抗体が作られる経路を発見

• 

  2013年7月12日
  メモリーB細胞が再感染から速やかに体を守る仕組みを解明

関連リンク

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採用情報

募集職種	応募締切
研究員募集（IMS304-2201）	ポストが決まり次第

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