Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1. Tran U.T. and Kitami T.
  "Chemical screens for particle-induced macrophage death identifies kinase inhibitors of phagocytosis as targets for toxicity."
  Journal of Nanobiotechnology. 22, 621 (2024)
• 2. Takeuchi T, Kubota T, Nakanishi Y, Tsugawa H, Suda W, Kwon AT, Yazaki J, Ikeda K, Nemoto S, Mochizuki Y, Kitami T, Yugi K, Mizuno Y, Yamamichi N, Yamazaki T, Takamoto I, Kubota N, Kadowaki T, Arner E, Carninci P, Ohara O, Arita M, Hattori M, Koyasu S, Ohno H.
  "Gut microbiota carbohydrate metabolism contributes to insulin resistance."
  Nature. 621, 389 (2023)
• 3. Kobayashi A, Azuma K, Takeiwa T, Kitami T, Horie K, Ikeda K, Inoue S."
  "FRET-based respirasome assembly screen defines potential therapeutic intervention that improves muscle mitochondrial respiration and exercise performance.
  Nature Communications. 14, 312 (2023)
• 4. Takeuchi T, Miyauchi E, Kanaya T, Kato T, Nakanishi Y, Watanabe T, Kitami T, Taida T, Sasaki T, Negishi H, Shimamoto S, Matsuyama A, Kimura I, Williams IR, Ohara O, Ohno H.
  "Acetate differentially regulates IgA reactivity to commensal bacteria."
  Nature. 595, 560 (2021)
• 5. Kitami T (co-first), Fukuda S, Kato T, Yamaguti K, Nakatomi Y, Yamano E, Kataoka Y, Mizuno K, Tsuboi Y, Kogo Y, Suzuki H, Itoh M, Morioka MS, Kawaji H, Koseki H, Kikuchi J, Hayashizaki Y, Ohno H, Kuratsune H, Watanabe Y.
  "Deep phenotyping of myalgic encephalomyelitis / chronic fatigue syndrome in Japanese population."
  Scientific Reports. 10, 19933 (2020)
• 6. Tran U.T. and Kitami T.
  "Niclosamide activates the NLRP3 inflammasome by intracellular acidification and mitochondrial inhibition."
  Communications Biology. 2, 2 (2019)
• 7. *Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK.
  "EMRE is an essential component of the mitochondrial calcium uniporter complex."
  Science. 342, 1379 (2013)
• 8. *Kitami T, Logan DJ, Negri J, Hasaka T, Tolliday NJ, Carpenter AE, Spiegelman BM, Mootha VK.
  "A chemical screen probing the relationship between mitochondrial content and cell size."
  PLoS One. 7, e33755 (2012)
• 9. *Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK.
  "Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation."
  Science. 336, 1040 (2012)
• 10. *Wagner BK, Kitami T (co-first), Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, Golub TR, Mootha VK.
  "Large-scale chemical dissection of mitochondrial function."
  Nature Biotechnology. 26, 343-51 (2008)

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