Research Summary

Selected Publications

• 1.Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A, Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y; FinnGen, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y.:
  "A cross-population atlas of genetic associations for 220 human phenotypes."
  Nature Genetics doi:10.1038/s41588-021-00931-x. (2021)
• 2.Uffelmann E, Huang QQ, Munung NS, de Vries J, Okada Y, Martin AR, Martin HC, Lappalainen T, PosthumaD.:
  "Genome-wide association studies"
  Nature Review Methods Primers. 1:59. (2021)
• 3.Tomofuji Y, Maeda Y, Oguro-Igashira E, Kishikawa T, Yamamoto K, Sonehara K, Motooka D, Matsumoto Y, Matsuoka H, Yoshimura M, Yagita M, Nii T, Ohshima S, Nakamura S, Inohara H, Takeda K, Kumanogoh A, Okada Y.:
  "Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese"
  Annals of the Rheumatic Diseases. doi:10.1136/annrheumdis-2021-220687. (2021)
• 4.COVID-19 Host Genetics Initiative.
  "Mapping the human genetic architecture of COVID-19"
  Nature. doi:10.1038/s41586-021-03767-x. (2021)
• 5.Naito T, Suzuki K, Hirata J, Kamatani Y, Matsuda K, Toda T, Okada Y.:
  "A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes"
  Nature Communications. 12:1639. (2021)
• 6.Sakaue S, Hirata J, Kanai M, Suzuki K, Akiyama M, Lai Too C, Arayssi T, Hammoudeh M, Al Emadi S, Masri BK, Halabi H, Badsha H, Uthman IW, Saxena R, Padyukov L, Hirata M, Matsuda K, Murakami Y, Kamatani Y, Okada Y.:
  "Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction"
  Nature Communications. 11:1569. (2020)
• 7.Sakaue S, Kanai M, Karjalainen J, Akiyama M, Kurki M, Matoba N, Takahashi A, Hirata M, Kubo M, Matsuda K, Murakami Y; FinnGen, Daly MJ, Kamatani Y, Okada Y.:
  "Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan"
  Nature Medicine. 26:542-548. (2020)
• 8.Hirata J, Hosomichi K, Sakaue S, Kanai M, Nakaoka H, Ishigaki K, Suzuki K, Akiyama M, Kishikawa T, Ogawa K, Masuda T, Yamamoto K, Hirata M, Matsuda K, Momozawa Y, Inoue I, Kubo M, Kamatani Y, Okada Y.:
  "Genetic and phenotypic landscape of the MHC region in the Japanese population"
  Nature Genetics. 51:470-480. (2019)
• 9.Sakaue S, Hirata J, Maeda Y, Kawakami E, Nii T, Kishikawa T, Ishigaki K, Terao C, Suzuki K, Akiyama M, Suita N, Masuda T, Ogawa K, Yamamoto Y, Saeki Y, Matsushita M, Yoshimura M, Matsuoka H, Ikari K, Taniguchi A, Yamanaka H, Kawaji H, Lassmann T, Itoh M, Yoshitomi H, Ito H, Ohmura K, Forrest A, Hayashizaki Y, Carninci P, Kumanogoh A, Kamatani Y, de Hoon M, Yamamoto K, Okada Y.:
  "Integration of genetics and miRNA-target gene network identified disease biology implicated in tissue specificity"
  Nucleic Acids Research. 46:11898-11909. (2018)
• 10.Okada Y, Momozawa Y, Sakaue S, Kanai M, Ishigaki K, Akiyama M, Kishikawa T, Arai Y, Sasaki T, Kosaki K, Suematsu M, Matsuda K, Yamamoto K, Kubo M, Hirose N, Kamatani Y.:
  "Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese"
  Nature Communications. 9:1631. (2018)

Recent Research Results

• 

  Feb. 13, 2023
  New genetic risk factors for rheumatoid arthritis revealed by analysis of multiple ancestry groups

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