Research Summary

Selected Publications

• 1. Namba S, Akiyama M, Hamanoue H, Kato K, Kawashima M, Kushima I, Matsuda K, Nakatochi M, Ogishima S, Sonehara K, Suzuki K, Takata A, Tamiya G, Tanikawa C, Yamamoto K, Yamamoto N, BioBank Japan Project, Ozaki N, Okada Y.
  "Inconsistent embryo selection across polygenic score methods"
  Nat Hum Behav, doi:10.1038/s41562-024-02019-y
• 2. Wang QS, Hasegawa T, Namkoong H, Saiki R, Edahiro R, Sonehara K, Tanaka H, Azekawa S, Chubachi S, Takahashi Y, Sakaue S, Namba S, Yamamoto K, Shiraishi Y, Chiba K, Tanaka H, Makishima H, Nannya Y, Zhang Z, Tsujikawa R, Koike R, Takano T, Ishii M, Kimura A, Inoue F, Kanai T, Fukunaga K, Ogawa S, Imoto S, Miyano S, Okada Y.
  "Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance"
  Nat Genet, 56, 2054-206. (2024)
• 3. Tomofuji Y, Edahiro R, Sonehara K, Shirai Y, Kock KH, Wang QS, Namba S, Moody J, Ando Y, Suzuki A, Yata T, Ogawa K, Naito T, Namkoong H, Xuan Lin QX, Buyamin EV, Tan LM, Sonthalia R, Han KY, Tanaka H, Lee H; Asian Immune Diversity Atlas Network, Japan COVID-19 Task Force, The BioBank Japan Project, Okuno T, Liu B, Matsuda K, Fukunaga K, Mochizuki H, Park WY, Yamamoto K, Hon CC, Shin JW, Prabhakar S, Kumanogoh A, Okada Y.
  "Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues"
  Cell Genom 100625. (2024)
• 4. Ojima T, Namba S, Suzuki K, Yamamoto K, Sonehara K, Narita A, Tohoku Medical Megabank Project Study Group, Biobank Japan Project, Kamatani Y, Tamiya G, Yamamoto M, Yamauchi T, Kadowaki T, Okada Y.
  "Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses.
  Nat Genet 56, 1100-1109. (2024)
• 5. Tomofuji Y, Sonehara K, Kishikawa T, Maeda Y, Ogawa K, Kawabata S, Nii T, Okuno T, Oguro-Igashira E, Kinoshita M, Takagaki M, Yamamoto K, Kurakawa T, Yagita-Sakamaki M, Hosokawa A, Motooka D, Matsumoto Y, Matsuoka H, Yoshimura M, Ohshima S, Nakamura S, Inohara H, Kishima H, Mochizuki H, Takeda K, Kumanogoh A, Okada Y.
  "Reconstruction of the personal information from human genome reads in gut metagenome sequencing data"
  Nat Microbiol 8, 1079-1094. (2024)
• 6. Edahiro R, Shirai Y, Takeshima Y, Sakakibara S, Yamaguchi Y, Murakami T, Morita T, Kato Y, Liu YC, Motooka D, Naito Y, Takuwa A, Sugihara F, Tanaka K, Wing JB, Sonehara K, Tomofuji Y, Japan COVID-19 Task Force, Namkoong H, Tanaka H, Lee H, Fukunaga K, Hirata H, Takeda Y, Okuzaki D, Kumanogoh A, Okada Y.
  "Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity"
  Nat Genet 55, 753-767. (2024)
• 7. Yamamoto K, Sonehara K, Namba S, Konuma T, Masuko H, Miyawaki S, BioBank Japan Project, Kamatani Y, Hizawa N, Ozono K, Yengo L, Okada Y.
  "Genetic footprints of assortative mating in the Japanese population"
  Nat Hum Behav 7, 65-73. (2024)
• 8. Namba S, Konuma T, Wu KH, Zhou W, Global Biobank Meta-analysis Initiative, Okada Y.
  "A practical guideline of genomics-driven drug discovery in the era of global biobank meta-analysis"
  Cell Genom 2, 100190. (2024)
• 9. Japan COVID-29 Task Force.
  "DOCK2 is involved in the host genetics and biology of severe COVID-19"
  Nature 609, 754-760. (2024)
• 10. The GIANT consortium.
  "A saturated map of common genetic variants associated with human height"
  Nature 610, 704-712. (2024)

Recent Research Results

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  Feb. 13, 2023
  New genetic risk factors for rheumatoid arthritis revealed by analysis of multiple ancestry groups

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