Research Summary

Selected Publications

• 1.Fujii, S*., and Shimizu, K.:
  "Exploiting antitumor immunotherapeutic novel strategies by deciphering the cross-talk between invariant NKT cells and dendritic cells."
  Frontiers Immunol. (in press). (*corresponding author)
• 2.Shimizu, K., Yamasaki, S., Shinga, J., Sato, Y., Watanabe, T., Ohara, O., Kuzushima, K., Yagita, H., Komuro, Y., Asakura, M., and Fujii, S*.:
  "Systemic DC activation modulates the tumor microenvironment and shapes the long-lived tumor-specific memory mediated by CD8+ T cells."
  Cancer Res. 76:3756-66 (2016) (*corresponding author)
• 3.Iyoda, T.,　Yamada, D., Vizcardo, R., Shimizu, K., Sato, Y., Endo, TA., Kitahara, G., Okoshi, M., Kobayashi, M., Sakurai, M., Ohara, O., Taniguchi, M., Koseki, H. *, Fujii S*.:
  "Efficient regeneration of Human Vα24⁺ invariant NKT cells and their anti-tumor activity in vivo."
  Stem Cells . 34:2852-2860 (2016)
• 4.Yamasaki, S., Shimizu, K., Kometani, K., Sakurai, M., Kawamura, M., and Fujii. S*.:
  "In vivo dendritic cell targeting cellular vaccine induces CD4⁺ Tfh cell-dependent antibody against influenza virus."
  Sci Rep. 6:35173 (2016)　
• 5.Li, Y., Takahashi, Y., Fujii, S., Zhou, Y., Hong, R., Suzuki, A., Tsubata, T., Hase, K., Wang, JY.,
  "EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity."
  Nat Commun. 3:10836. (2016)
• 6.Sato, Y., Shimizu, K., Shinga, J., Hidaka, M., Kawano, F., Kakimi, K., Yamasaki, S., Asakura, M., Fujii, S*.:
  "Characterization of the myeloid-derived suppressor cell subset regulated by NK cells in malignant lymphoma."
  Oncoimmunology. 4(3):e995541. (2015)
• 7.Shimizu, K., Shinga, J., Yamasaki, S., Kawamura, M., Dörrie, J., Schaft, N., Sato, Y., Iyoda, T., Fujii, S*.:
  "Transfer of mRNA Encoding Invariant NKT Cell Receptors Imparts Glycolipid Specific Responses to T Cells and γδT Cells."
  PLoS One. 10(6):e0131477. (2015)
• 8.Shimizu, K., Sato, Y., Shinga, J., Watanabe, T., Endo, T., Asakura, M., Yamasaki, S., Kawahara, K., Kinjo, Y., Kitamura, H., Watarai, H., Ishii, Y., Tsuji, M., Taniguchi, M., Ohara, O., Fujii, S*.:　
  "KLRG1+invariant natural killer T cells are long-lived effectors."
  Proc Natl Acad Sci USA. 111:12474-12479. (2014)
• 9.Shimizu, K., Mizuno, T., Shinga, J., Asakura, M., Kakimi, K., Ishii, Y., Masuda, K., Maeda, T., Sugahara, H., Sato, Y., Matsushita, H., Nishida, K., Hanada, KI., Dörrie, J., Schaft, N., Bickham, K., Koike, H., Ando, T., Nagai, R., Fujii S*.:
  "Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells."
  Cancer Res. 73:62-73. (2013)
• 10.Shimizu, K., Asakura, M., Shinga, J., Sato, Y., Kitahara, S., Hoshino, K., Kaisho, T., Schoenberger, SP., Ezaki, T., Fujii, S*.:
  "Invariant NKT cells induce plasmacytoid DC cross-talk with conventional DCs for efficient memory CD8+ T cell induction."
  J Immunol. 190(11):5609-19. (2013)

Recent Research Results

• 

  Dec. 28, 2021
  Immune response to seasonal coronaviruses may offer protection against COVID-19

• 

  Jul. 1, 2016
  New anti-cancer strategy mobilizes both innate and adaptive immune response

• 

  Jan. 23, 2015
  Expanding the immune system’s memory

• 

  Apr. 26, 2013
  Giving antitumor immunity a helping hand

Related Links

Lab Members

Contact Information

1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-7062
Fax: +81-(0)45-503-7061
Email: shin-ichiro.fujii [at] riken.jp