RIKEN Center for Integrative Medical Sciences Laboratory for Transcriptional Regulation

Team Director: Ichiro Taniuchi (M.D., Ph.D)

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Research Summary

Gene regulation by transcription factors networks plays a central role in development of multi-cellular organisms. The aims of researches in my laboratory are to understand of how genetic program that governs immune cell development is controlled and evolved from the view of transcriptional regulation. In particular, we will focus on mechanisms of silencer-mediated gene repression and functions of Runx transcription factor family. Finally, we wish to apply our findings to develop new technology that will be applied to control human diseases.

Main Research Fields

Medicine, Dentistry & Pharmacy

Related Research Fields

Biological Sciences
Biology
Medicine, Dentistry & Pharmacy
Immunology
Molecular Biology

Keywords

Immune cell development
Epigenetics
Transcription factors
Mouse genetics

Selected Publications

1. Okuyama K. Yamashita M, Koumoundourou A, Wiegreffe C, Ohno-Oishi M, Murphy S, Zhao X, Yoshida H, Ebihara T, Satoh-Takayama N, Kojo S, Ohno H, Morio T, Wu Y, Puck J, Xue H-H, Britsch S, Taniuchi I.:
"A mutant Bcl11b^N440K protein interferes with Bcl11a function during T lymphocyte and neuronal development."
Nat Immunol. 2024 Nov 1. doi: 10.1038/s41590-024-01997-5
2. Matsumoto K, Okuyama K, Sidwell T, Yamashita M, Endo T, Satoh-Takayama N, Ohno H, Morio T, Rothenberg EV, Taniuchi I.:
"A Bcl11b^N797K variant isolated from an immunodeficient patient inhibits early thymocyte development in mice."
Front Immunol. 15:1363704, (2024)
3. Chang J, Yamashita M, Padhi AK, Zhang KYJ, Taniuchi I.:
"Impaired tissue homing by the Ikzf3^N159S variant is mediated by interfering with Ikaros function"
Front. Immunol. 14:1239779, (2023)
4. Nomura A, Kobayashi T. Seo W, Ohno-Oishi M, Kakugawa K, Muroi S, Yoshida H, Endo TA, Moro K, Taniuchi I.:
"Identification of a novel enhancer essential for Satb1 expression in T_H2 cells and activated ILC2s."
Life Sci Alliance 6:e202301897, (2023)
5. Okuyama K, Nomura A, Nishino K, Tanaka H, Harly C, Chihara R, Harada Y, Muroi S, Kubo M, Kosako H, Taniuchi I.:
"The Majority of the Serine/Threonine Phosphorylation Sites in Bcl11b Protein Are Dispensable for the Differentiation of T Cells."
J. Immunol. 210:1728-1739, (2023).
6. Yamashita M, Kuehn HS, Okuyama K, Okada S, Inoue Y, Mitsuiki N, Imai K, Takagi M, Kanegane H, Takeuchi M, Shimojo N, Tsumura M, Padhi AK, Zhang KYJ, Boisson B, Casanova JL, Ohara O, Rosenzweig SD, Morio T, Taniuchi I.:
"A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS."
Nat Immunol. 22:893-903, (2021)
7. Liu M, Kuo F, Capistrano KJ, Kang D, Nixon BG, Shi W, Chou C, Do MH, Stamatiades EG, Gao S, Li S, Chen Y, Hsieh JJ, Hakimi AA, Taniuchi I, Chan TA, Li MO.:
"TGFβ Suppresses Type 2 Immunity to Cancer."
Nature 87:115-120, (2020)
8. Seo W, Shimizu K, Kojo S, Okeke A, Kowhi-Shigematsu T, Fujii SI, Taniuchi I.:
"Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity."
Nat Commun. 11:1562, (2020)
9. Kojo S, Yasmin N, Muroi S, Tenno M, Taniuchi I.:
"Runx-dependent and silencer-independent repression of maturation enhancer in the Cd4 gene"
Nat. Commun. 9:3593, (2018)
10. Taniuchi I.:
"CD4 helper/ CD8 cytotoxic T cell differentiation"
Annual Rev Immunol. 36:579-601, (2018)