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RIKEN Center for Biosystems Dynamics Research Human Biomimetic System RIKEN Hakubi Research Team

RIKEN Hakubi Team Leader: Masaya Hagiwara (Ph.D.)

Research Summary

Masaya  Hagiwara

The overall objective is the development of in-vitro experimental platform to reconstitute the biological system outside our bodies by controlling cellular micro-environments. Especially lung airway is the one of my major targets. The scientific question is how the airway cells can organize such a sophisticated structure by themselves. The repetitive feedbacks between in-vitro experiments and mathematical model give us a tremendous amount of useful information, and I am challenging to unveil the system underlying self-organization of tissue formation by directing complex tissue structure. Development of Organ or Body-on-a-Chip system is another research target for the animal testing alternative.

Main Research Fields

  • Complex Systems

Related Research Fields

  • Informatics
  • Interdisciplinary Science & Engineering
  • Mathematical & Physical Sciences
  • Chemistry
  • Engineering
  • Biological Sciences
  • Biology
  • Medicine, Dentistry & Pharmacy
  • Biomedical engineering/Biomaterial science and engineering
  • Nano/Microsystems
  • Intelligent mechanics/Mechanical systems

Keywords

  • In vitro tissue formation
  • Tissue imaging
  • Organ on a Chip
  • Culture Control

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

  • 1. Koh, I., Hagiwara, M.:
    "Modular tissue-in-a-CUBE platform to model blood-brain barrier (BBB) and brain interaction"
    Communications Biology 7, 177 (2024)
  • 2. Koh, I., Hagiwara, M.:
    "Gradient to sectioning CUBE workflow for the generation and imaging of organoids with localized differentiation"
    Communications Biology 6(1), 299 (2023)
  • 3. Suthiwanich, K., Hagiwara, M.:
    "Localization of multiple hydrogels with MultiCUBE platform spatially guides 3D tissue morphogenesis in vitro"
    Advanced Material Technologies, 8, 4, (2023)
  • 4. Takano, A., Koh, I., and Hagiwara, M.:
    "3D Culture Platform for Enabling Large-Scale Imaging and Control of Cell Distribution into Complex Shapes by Combining 3D Printing with a Cube Device"
    Micromachines, 13, 156, (2022)
  • 5. Hagiwara, M., Maruyama, H., Akiyama, M., Koh, I., Arai, F.:
    "Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation"
    Communications Biology volume 4, 808 (2021)
  • 6. *Hagiwara, M., Nobata, R., Kawahara, T.:
    "High repeatability from 3D experimental platform for quantitative analysis of cellular branch pattern formations"
    Integrative Biology, 10, 306-312, (2018).
  • 7. *Hagiwara, M., Nobata, R., Kawahara, T.:
    "Large scale imaging by fine spatial alignment of multi-scanning data with gel cube device"
    Applied Sciences, 8, doi:10.3390/app8020235, (2018).
  • 8. *Hagiwara, M., Maruta, M., Marumoto, M.:
    "In Vitro Experimental Model for the Long-Term Analysis of Cellular Dynamics During Bronchial Tree Development from Lung Epithelial Cells"
    Tissue Engineering Part C: Methods, 23, 323-332, (2017).
  • 9. *Hagiwara, M:
    "An in vitro–in silico interface platform for spatiotemporal analysis of pattern formation in collective epithelial cells"
    Integrative Biology, 8, 861-868, (2016).
  • 10. *Hagiwara, M., Nobata, R., Kawahara, T.:
    "Tissue in Cube: In Vitro 3D Culturing Platform with Hybrid Gel Cubes for Multidirectional Observations"
    Advanced Healthcare Materials, 5, 1566-1571, (2016).

Recent Research Results

Lab Members

Principal investigator

Masaya Hagiwara
RIKEN Hakubi Team Leader

Core members

Yen Xuan Ngo
Postdoctoral Researcher
Marlar Saw
Technical Staff I
Satoko Kinoshita
Assistant

Careers

Position Deadline
Seeking a Research Scientist or Postdoctoral Researcher (K24101) Open until filled

Contact Information

N404, RIKEN IIB
6-7-1 Minatojima-minamimachi,
Chuou-ku, Kobe,
650-0047, Japan
Tel: +81-(0)78-569-8870
Email: masaya.hagiwara@riken.jp

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