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RIKEN Center for Biosystems Dynamics Research Laboratory for Ultrastructural Research

Team Leader: Shigenobu Yonemura (Ph.D.)

Research Summary

Shigenobu Yonemura

This research team analyzes detailed morphological information in various researches of the life science field, which is acquired through ultrastructural techniques using transmission and scanning electron microscopy. In collaboration with many laboratories including within RIKEN, we have accumulated a large amount of experiences to improve methods for better morphology.

Main Research Fields

  • Biology

Related Research Fields

  • Medicine, Dentistry & Pharmacy


  • Multicellular morphogenesis
  • Cell polarity
  • Mechanobiology

Selected Publications

  • 1. Fukuda K, Shimi T, Shimura C, et al.
    "Epigenetic plasticity safeguards heterochromatin configuration in mammals"
    Nucleic Acids Research (2023)
    doi: 10.1093/nar/gkad387
  • 2. Takayuki O, Aramaki T, Takai A, et al.
    "Cranial cartilages: Players in the evolution of the cranium during evolution of the chordates in general and of the vertebrates in particular."
    Evolution & Development 25(3), 197-208 (2023)
    doi: 10.1111/ede.12433
  • 3. Tentaku A. Kurisu S. Sejima K. et al.
    "Proximal deposition of collagen IV by fibroblasts contributes to basement membrane formation by colon epithelial cells in vitro"
    The FEBS Journal 289(23), 7466-7485 (2022)
    doi: 10.1111/febs.16559
  • 4. Nishimura R, Kato K, Saida M, et al.
    "Appropriate tension sensitivity of α-catenin ensures rounding morphogenesis of epithelial spheroids."
    Cell Structure and Function 24(2), 55-73 (2022)
    doi: 10.1247/csf.22014
  • 5. Saito H, Matsukawa-Usami F, Fujimori T, et al.
    "Tracheal motile cilia in mice require CAMSAP3 for the formation of central microtubule pair and coordinated beating."
    doi: 10.1091/mbc.E21-06-0303
  • 6. Yonemura S.
    "Actin filament association at adherens junctions."
    The journal of medical investigation : JMI 64(1.2), 14-19 (2017)
    doi: 10.2152/jmi.64.14
  • 7. Tsujioka M, Yumura S, Inouye K, et al.
    "Talin couples the actomyosin cortex to the plasma membrane during rear retraction and cytokinesis"
    Proceedings of the National Academy of Sciences of the United States of America 109(32), 12992-12997 (2012)
    doi: 10.1073/pnas.1208296109
  • 8. Yonemura S.
    A mechanism of mechanotransduction at the cell-cell interface: emergence of α-catenin as the center of a force-balancing mechanism for morphogenesis in multicellular organisms."
    Bioessays 33(10), 732-736 (2011)
    doi: 10.1002/bies.201100064
  • 9. Yonemura S.
    "Cadherin-actin interactions at adherens junctions."
    Current Opinion in Cell Biology 23(5), 525-522 (2011)
    doi: 10.1016/j.ceb.2011.07.001
  • 10. Yonemura S, Wada Y, Watanabe T, et al.
    "alpha-Catenin as a tension transducer that induces adherens junction development."
    Nature Cell Biology 12(6), 533-542 (2010)
    doi: 10.1038/ncb2055

Recent Research Results

Related Links

Lab Members

Principal investigator

Shigenobu Yonemura
Team Leader

Core members

Shigeo Hayashi
Deputy Team Leader
Kenta Onoue
Technical Staff I
Satoko Okayama
Technical Staff I

Contact Information

2-2-3 Minatojima-minamimachi, Chuo-ku
Kobe, Hyogo
650-0047 Japan
Tel: 078-306-3105
Email: Email: shigenobu.yonemura [at] riken.jp