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RIKEN BioResource Research Center (BRC®) Cell Engineering Division (RIKEN BRC Cell Bank)

Director: Yukio Nakamura (M.D., Ph.D.)

Research Summary

Yukio  Nakamura(M.D., Ph.D.)

"Cell Engineering Division in RIKEN BioResource Center (BRC®)" was originally organized as the "RIKEN Cell Bank" in 1987. It is a unique, not-for-profit public organization for deposit, standardization, preservation, and distribution of cultured animal cell lines produced by life science community. We conduct not only banking of cell materials but also research and development related to cell engineering, such as establishment of novel human and animal cell lines and development of technology to culture primate pluripotent stem cells efficiently.

Main Research Fields

  • Biological Sciences

Related Research Fields

  • Biology


  • Hematology
  • Mesenchymal Stem Cell

Selected Publications

  • 1.Yamada, T., Abei, M., Danjoh, I., Shirota, R., Yamashita, T., Hyodo, I., and Nakamura, Y.:
    “Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib.”
    BMC Cancer 15: 260. doi: 10.1186/s12885-015-1297-7 (2015)
  • 2.Yamada, K. and Nakamura, Y.:
    “High dose of D-glucose enhances cell growth in primary cultures of C. elegans cells.”
    Worm Breeder's Gazette 20: 16-17 (2014)
  • 3.Kurita, R., Suda, N., Sudo, K., Miharada, K., Hiroyama, T., Miyoshi, H., Tani, K., and Nakamura, Y.:
    “Establishment of immortalized human erythroid progenitor cell lines able to produce enucleated red blood cells.”
    PLoS ONE 8: e59890 (2013)
  • 4.Danjoh, I., Shirota, R, Hiroyama, T., and Nakamura, Y.:
    “Dominant expansion of a cryptic subclone with an abnormal karyotype in B lymphoblastoid cell lines during culture.”
    Cytogen. Genome Res. 139: 88-96 (2013)
  • 5.Danjoh, I., Sone, H., Shirota, R., Hiroyama, T., and Nakamura, Y.:
    “Development of a robust method for establishing B cell lines using Epstein-Barr Virus.”
    In Vitro Cell. Dev. Biol. - Animal 48: 393-402 (2012)
  • 6.Miharada, K., and Nakamura, Y.:
    “In vitro production of enucleated red blood cells from hematopoietic stem and progenitor cells.”
    Methods Mol. Biol. 879: 505-512 (2012)
  • 7.Hiroyama, T., Miharada, K., Kurita, R., and Nakamura, Y.:
    “Plasticity of cells and ex vivo production of red blood cells.”
    Stem Cell Int. 2011: Article ID 195780, open access journal, doi:10.4061/2011/195780 (2011)
  • 8.Danjoh, I., Saijo, K., Hiroyama, T., and Nakamura, Y.:
    “The Sonoda-Tajima Cell Collection, a human genetics research resource with emphasis on South American indigenous populations.”
    Genome Biol. Evol. 3: 272-283, open access journal, doi:10.1093/gbe/evr014 (2011)
  • 9.Sudo, K., Yasuda, J., and Nakamura, Y.:
    “Gene expression profiles of cryopreserved CD34+ human umbilical cord blood cells are related to their bone marrow reconstitution abilities in mouse xenografts.”
    Biochem. Biophys. Res. Commun. 397: 697-705 (2010)
  • 10.Fujioka, T., Shimizu, N., Miyoshi, H., and Nakamura, Y.:
    “Establishment of induced pluripotent stem cells from human neonatal tissues.”
    Hum. Cell 23: 113-118 (2010)

Related Links

Lab Members

Principal investigator

Yukio Nakamura

Core members

Takashi Hiroyama
Senior Research Scientist
Tsuyoshi Fujioka
Technical Scientist
Fumio Kasai
Research Scientist
Kazuhiro Sudo
Research & Development Scientist
Michiya Noguchi
Technical Scientist
Masanori Hatori
Technical Scientist
Naoko Aoki
Technical Staff II
Saeri Ogawa
Technical Staff II
Kanae Kurita
Technical Staff II
Sumie Togayachi
Technical Staff II
Kumiko Mizukoshi
Technical Staff II

Contact Information

BioResource Building for Cell Research
3-1-1 Koyadai, Tsukuba, Ibaraki, 305-0074, Japan
Tel: +81-(0)29-836-9124
Fax: +81-(0)29-836-9130
Email: yukio.nakamura [at] riken.jp