RIKEN BioResource Research Center (BRC®) Experimental Animal Division
Director: Atsushi Yoshiki (Ph.D.)
Research Summary
We contribute to the promotion of life science through collection, preservation, quality control and distribution of useful model mice developed in Japan for the study of physiological functions and diseases. Since 2002, we have been designated as the core facility of mouse resources in the National BioResource Project of the MEXT, participated as a key member in the International Mouse Strain Resource and Asian Mouse Mutagenesis & Resource Association, and collaborated as an international hub of mouse resources with major repositories around the globe. In addition, we participate in the International Mouse Phenotyping Consortium and partly produce and distribute KO mice of all genes to contribute to biomedical scientific community.
Main Research Fields
- Biological Sciences
Related Research Fields
- Complex Systems
- Biology
- Medicine, Dentistry & Pharmacy
Keywords
- Mouse Resources
- Quality Control
- Genome edited mice
- Animal Models for Human Disease
- Reproducibility of Experiments
Selected Publications
- 1.Karp NA et al.
"Prevalence of sexual dimorphism in mammalian phenotypic traits."
Nat Commun 8, 15475 (2017). - 2.Horie M, Mekada K, Sano H, Kikkawa Y, Chiken S, Someya T, Saito K, Hossain MI, Nameta M, Abe K, Sakimura K, Ono K, Nambu A, Yoshiki A, Takebayashi H.
"Characterization of novel dystonia musculorum mutant mice: Implications for central nervous system abnormality."
Neurobiol Dis 96:271-283 (2016). - 3.Dickinson ME et al.
"High-throughput discovery of novel developmental phenotypes."
Nature 537, 508-514 (2016). - 4.Al-Soudy AS, Nakanishi T, Mizuno S, Hasegawa Y, Shawki HH, Katoh MC, Basha WA, Ibrahim AE, El-Shemy HA, Iseki H, Yoshiki A, Hiromori Y, Nagase H, Takahashi S, Oishi H, Sugiyama F.
"Germline recombination in a novel Cre transgenic line, Prl3b1-Cre mouse."
Genesis 54, 389-97 (2016). - 5.Hasegawa Y, Hoshino Y, Ibrahim AE, Kato K, Daitoku Y, Tanimoto Y, Ikeda Y, Oishi H, Takahashi S, Yoshiki A, Yagami K, Iseki H, Mizuno S, Sugiyama F.
"Generation of CRISPR/Cas9-mediated bicistronic knock-in ins1-cre driver mice."
Exp Anim 65, 319-27 (2016). - 6.Takada T, Yoshiki A, Obata Y, Yamazaki Y, Shiroishi T.
"NIG_MoG: a mouse genome navigator for exploring intersubspecific genetic polymorphisms."
Mamm Genome 26, 331-337 (2015). - 7.Sugimoto M, Kondo M, Koga Y, Shiura H, Ikeda R, Hirose M, Ogura A, Murakami A, Yoshiki A, Chuva de Sousa Lopes SM, Abe K.
"A simple and robust method for establishing homogeneous mouse epiblast stem cell lines by wnt inhibition."
Stem Cell Reports 4, 744-57 (2015). - 8.Mekada K, Hirose M, Murakami A, Yoshiki A.
"Development of SNP markers for C57BL/6N-derived mouse inbred strains."
Exp Anim 64, 91-100 (2014). - 9.Hasegawa Y, Daitoku Y, Mizuno S, Tanimoto Y, Mizuno-Iijima S, Matsuo M, Kajiwara N, Ema M, Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K.
"Generation and characterization of Ins1-cre-driver C57BL/6N for exclusive pancreatic beta cell-specific Cre-loxP recombination."
Exp Anim 63, 183-91 (2014). - 10.Kitamura, T., Pignatelli, M., Suh, J., Kohara, K., Yoshiki, A., Abe, K. and Tonegawa, S.:
"Island cells control temporal association memory."
Science 343, 896-901 (2014).
Events
Publications
Related Links
Lab Members
Principal investigator
- Atsushi Yoshiki
- Director
Core members
- Fumio Ike
- Senior Research Scientist
- Toshiaki Nakashiba
- Senior Research Scientist
- Noriko Hiraiwa
- Senior Technical Scientist
- Hatsumi Nakata
- Senior Technical Scientist
- Shinya Ayabe
- Research Scientist
- Saori Mizuno
- Postdoctoral Researcher
- Masayo Kadota
- Technical Staff II
- Megumi Tanaka
- Technical Staff II
- Mizuho Iwama
- Technical Staff II
- Maiko Ijuin
- Technical Staff II
- Tomomi Hashimoto
- Technical Staff II
- Kyuichi Taguma
- Technical Staff II
Contact Information
3-1-1 Koyadai
Tsukuba, Ibaraki
305-0074 Japan
Email: atsushi.yoshiki [at] riken.jp