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RIKEN BioResource Research Center (BRC®) Integrated Bioresource Information Division

Director: Hiroshi Masuya (Ph.D.)

Research Summary

Hiroshi  Masuya(Ph.D.)

As it is exactly said “No data, No resource”, “Information” is an essential element of bioresources as the basic infrastructure for promotion of the life science. Integrated Bioresource Information Division develops information technology that describes and integrates bioresources related information including genome, phenotype and its utilization in scientific studies. The Division also aims and facilitate wide, effective and efficient use of bioresources for R&D in science and industry by analyses of bioresource-related big data and operation of the Website.

Main Research Fields

  • Informatics

Related Research Fields

  • Complex Systems
  • Humanities
  • Interdisciplinary Science & Engineering
  • Mathematical & Physical Sciences
  • Engineering
  • Biological Sciences
  • Biology
  • Agricultural Sciences
  • Medicine, Dentistry & Pharmacy
  • Intelligent informatics
  • Life & Health & Medical informatics
  • Mathematical informatics


  • Data integration
  • Ontology
  • Semantic Web
  • Mathematical informatics
  • Statistical analysis

Selected Publications

  • 1.Nobuhiko Tanaka and Hiroshi Masuya.:
    "Mouse phenome as a biological resource"
    Impact, Volume 2018, Number 12, December 2018, pp. 93-95(3)
  • 2.Kobayashi N, Kume S, Lenz K, Masuya H.:
    "RIKEN MetaDatabase: A Database Platform for Health Care and Life Sciences as a Microcosm of Linked Open Data Cloud"
    Int. J. Semantic Web Inf. Syst. 14(1) 140-164 (2018)
  • 3.Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H; IMPC Consortium, Hough T, Mallon AM, Wells S, Santos L, Lelliott CJ, White JK, Sorg T, Champy MF, Bower LR, Reynolds CL, Flenniken AM, Murray SA, Nutter LMJ, Svenson KL, West D, Tocchini-Valentini GP, Beaudet AL, Bosch F, Braun RB, Dobbie MS, Gao X, Herault Y, Moshiri A, Moore BA, Kent Lloyd KC, McKerlie C, Masuya H, Tanaka N, Flicek P, Parkinson HE, Sedlacek R, Seong JK, Wang CL, Moore M, Brown SD, Tschöp MH, Wurst W, Klingenspor M, Wolf E, Beckers J, Machicao F, Peter A, Staiger H, Häring HU, Grallert H, Campillos M, Maier H, Fuchs H, Gailus-Durner V, Werner T, Hrabe de Angelis M.:
    "Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
    Nat Commun. 18;9:288. doi: 10.1038/s41467-017-01995-2. (2018)"
  • 4.Bowl MR, Simon MM, Ingham NJ, Greenaway S, Santos L, Cater H, Taylor S, Mason J, Kurbatova N, Pearson S, Bower LR, Clary DA, Meziane H, Reilly P, Minowa O, Kelsey L; International Mouse Phenotyping Consortium(as a collaborator of the consortium), Tocchini-Valentini GP, Gao X, Bradley A, Skarnes WC, Moore M, Beaudet AL, Justice MJ, Seavitt J, Dickinson ME, Wur st W, de Angelis MH, Herault Y, Wakana S, Nutter LMJ, Flenniken AM, McKerlie C, Murray SA, Svenson KL, Braun RE, West DB, Lloyd KCK, Adams DJ, White J, Karp N, Flicek P, Smedley D, Meehan TF, Parkinson HE, Teboul LM, Wells S, Steel KP, Mallon AM, Brown SDM.:
    "A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction."
    Nat Commun. 8 :886. doi: 10.1038/s41467-017-00595-4. (2017)
  • 5.Karp NA, Mason J, Beaudet AL, Benjamini Y, Bower L, Braun RE, Brown SDM, Chesler EJ, Dickinson ME, Flenniken AM, Fuchs H, Angelis MH, Gao X, Guo S, Greenaway S, Heller R, Herault Y, Justice MJ, Kurbatova N, Lelliott CJ, Lloyd KCK, Mallon AM, Mank JE, Masuya H, McKerlie C, Meehan TF, Mott RF, Murray SA, Parkinson H, Ramirez-Solis R, Santos L, Seavitt JR, Smedley D, Sorg T, Speak AO, Steel KP, Svenson KL; International Mouse Phenotyping Consortium, Wakana S, West D, Wells S, Westerberg H, Yaacoby S, White JK.:
    "Prevalence of sexual dimorphism in mamma lian phenotypic traits."
    Nat Commun. 8:15475. doi: 10.1038/ncomms15475. (2017)
  • 6.Yamaguchi A, Kozaki K, Yamamoto Y,Masuya H and Kobayashi N.:
    "LOD Surfer API: Web API for LOD Surfing Using Class-Class Relationships in Life Sciences."
    Proceedings of the 10th International Conference on Semantic Web Applications and Tools for Health Care and Life Sciences (SWAT4LS 2017), Rome, Italy, December 4-7, (2017).
  • 7.Kobayashi N, Kume S, Masuya H.:
    "Metadata-driven Interdisciplinary Research Projects Using RIKEN MetaDatabase."
    Proceedings of the 10th International Conference on Semantic Web Applications and Tools for Health Care and Life Sciences (SWAT4LS 2017), Rome, Italy, December 4-7, (2017)
  • 8.Yamaguchi A, Kozaki K, Lenz K, Yamamoto Y, Masuya H, Kobayashi N.:
    "Semantic Data Acquisition by Traversing Class-Class Relationships over the Linked Open Data"
    Semantic Technology:JIST2016, 10055, 136-151 DOI: 10.1007/978-3-319-50112-3_11 (2016)
  • 9.Kimura M, Ichimura S, Sasaki K, Masuya H, Suzuki T, Wakana S, Ikegawa S, Furuichi T.:
    "Endoplasmic reticulum stress-mediated apoptosis contributes to a skeletal dysplasia resembling platyspondylic lethal skeletal dysplasia, Torrance type, in a novel Col2a1 mutant mouse line."
    Biochem Biophys Res Commun. 468:86-91. doi: 10.1016/j.bbrc.2015.10.160. (2015)
  • 10.Maier H, Schütt C, Steinkamp R, Hurt A, Schneltzer E, Gormanns P, Lengger C, Griffiths M, Melvin D, Agrawal N, Alcantara R, Evans A, Gannon D, Holroyd S, Kipp C, Raj NP, Richardson D, LeBlanc S, Vasseur L, Masuya H, Kobayashi K, Suzuki T, Tanaka N, Wakana S, Walling A, Clary D, Gallegos J, Fuchs H, de Angelis MH, Gailus-Durner V.:
    "Principles and application of LIMS in mouse clinics."
    Mamm Genome. 9-10:467-481. doi: 10.1007/s00335-015-9586-7. Review. (2015)

Related Links

Lab Members

Principal investigator

Hiroshi Masuya

Contact Information

Room 113, Information and JCM Building,
3-1-1 Koyadai,
Tsukuba, Ibaraki,
305-0074 Japan
Tel: +81-(0)29-829-9112
Fax: +81-(0)29-836-9337
Email: hiroshi.masuya [at] riken.jp