Research Summary

The technology to generate induced Pluripotent Stem (iPS) cells opened a new way for research of disease through the generation and utilization of iPS cells derived from patients (disease-specific iPS cells). This unit aims to develop a new screening method for drug discovery using the diseased cells of each disease derived from disease-specific iPS cells.

Main Research Fields

• Biological Sciences

Related Research Fields

• Biology

Keywords

• Hematology
• Mesenchymal Stem Cell

Selected Publications

• 1.Yamada, T., Abei, M., Danjoh, I., Shirota, R., Yamashita, T., Hyodo, I., and Nakamura, Y.:
  "Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib."
  BMC Cancer 15: 260. doi: 10.1186/s12885-015-1297-7 (2015)
• 2.Yamada, K. and Nakamura, Y.:
  "High dose of D-glucose enhances cell growth in primary cultures of C. elegans cells."
  Worm Breeder's Gazette 20: 16-17 (2014)
• 3.Kurita, R., Suda, N., Sudo, K., Miharada, K., Hiroyama, T., Miyoshi, H., Tani, K., and Nakamura, Y.:
  "Establishment of immortalized human erythroid progenitor cell lines able to produce enucleated red blood cells."
  PLoS ONE 8: e59890 (2013)
• 4.Danjoh, I., Shirota, R, Hiroyama, T., and Nakamura, Y.:
  "Dominant expansion of a cryptic subclone with an abnormal karyotype in B lymphoblastoid cell lines during culture."
  Cytogen. Genome Res. 139: 88-96 (2013)
• 5.Danjoh, I., Sone, H., Shirota, R., Hiroyama, T., and Nakamura, Y.:
  "Development of a robust method for establishing B cell lines using Epstein-Barr Virus."
  In Vitro Cell. Dev. Biol. - Animal 48: 393-402 (2012)
• 6.Miharada, K., and Nakamura, Y.:
  "In vitro production of enucleated red blood cells from hematopoietic stem and progenitor cells."
  Methods Mol. Biol. 879: 505-512 (2012)
• 7.Hiroyama, T., Miharada, K., Kurita, R., and Nakamura, Y.:
  "Plasticity of cells and ex vivo production of red blood cells."
  Stem Cell Int. 2011: Article ID 195780, open access journal, doi:10.4061/2011/195780 (2011)
• 8.Danjoh, I., Saijo, K., Hiroyama, T., and Nakamura, Y.:
  "The Sonoda-Tajima Cell Collection, a human genetics research resource with emphasis on South American indigenous populations."
  Genome Biol. Evol. 3: 272-283, open access journal, doi:10.1093/gbe/evr014 (2011)
• 9.Sudo, K., Yasuda, J., and Nakamura, Y.:
  "Gene expression profiles of cryopreserved CD34⁺ human umbilical cord blood cells are related to their bone marrow reconstitution abilities in mouse xenografts."
  Biochem. Biophys. Res. Commun. 397: 697-705 (2010)
• 10.Fujioka, T., Shimizu, N., Miyoshi, H., and Nakamura, Y.:
  "Establishment of induced pluripotent stem cells from human neonatal tissues."
  Hum. Cell 23: 113-118 (2010)

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