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RIKEN Baton Zone Program Emerging Infectious Disease Vaccine Technology Laboratory

Team Leader: Ken-ichi Masuda (Ph.D.)
Deputy Team Leader: Hiroshi Ohno (M.D., Ph.D)
Deputy Team Leader: Masato Kubo (Ph.D.)

Research Summary

Ken-ichi  Masuda(Ph.D.) Hiroshi Ohno Masato Kubo

The multiple antigenic peptides (MAP) can directly stimulate antibody-producing cells to induce IgM antibody, which remains in the serum for an extended period and serves as memory cells, in preparation for the next infection. The peptides used in MAP are selected from well-conserved sequences of amino acids among mutant viruses, allowing vaccines to be developed against future unknown mutant strains. This technology is useful against novel coronaviruses (SARS-CoV-2), highly pathogenic avian influenza viruses, and dengue viruses, which are considered difficult to deal with mutant strains using conventional vaccine technology.

[Integrated Collaborative Research with Animal Allergy Clinical Laboratories Inc.]

Main Research Fields

  • Biology

Related Research Fields

  • Agricultural Sciences
  • Medicine, Dentistry & Pharmacy
  • Immunology-related
  • Virology-related
  • Veterinary medical science-related


  • Vaccine
  • Mutant-virus compatible
  • Zoonosisi
  • Long term induction of IgM
  • Avoidance of antibody-dependent enhancement

Selected Publications

  • 1. Kumagai, A., Nara, T., Uematsu, M., Kakinuma, Y., Saito, T., and Masuda, K.:
    “Development and characterization of a unique anti-IgE mouse monoclonal antibody cross-reactive between human and canine IgE”
    Immunity, Inflammation and Disease. Volume 9, pp 1740-1748. (2021)
  • 2. Takuya Nara, Hiroshi Shimoda, Chitose Suzuki, Ngo Thuy Bao Tran, Hina Tsukada, Hiroki Okayama, Hu Weiyin, Miho Obata, Saki Mitsunaga, Masashi Sakurai, Yudai Kuroda, Ken Maeda, Masato Kubo, Takashi Saito, Kenichi Masuda. :
    “An octavalent dendrimer of multiple antigenic peptide with a property of pan-coronavirus IgM induction improved clinical signs of feline infectious peritonitis in cats.“
    Veterinary Vaccine. Available online 13 March 2024.

Related Links

Lab Members

Principal investigator

Ken-ichi Masuda
Team Leader

Core members

Hiroshi Ohno
Deputy Team Leader
Masato Kubo
Deputy Team Leader
Takashi Saito
Senior Visiting Scientist
Takuya Nara
Visiting Technician
Yudai Murakami
Visiting Technician
Kana Matsumura
Visiting Technician

Contact Information

North Building 4th Floor
1-7-22 Suehiro-cho, Tsurumi-ku,
Yokohama City, Kanagawa,
230-0045, Japan
Tel: +81-(0)45-503-9699
Email: kenichi.masuda [at] riken.jp