Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1. Okamoto, K., Hibino, K., and Sako, Y.:
  "In-cell single-molecule FRET measurements reveal three conformational state changes in RAF protein"
  Biochim. Biophys. Acta. Gen. Subj. 1864(2), 129358 (2020).
• 2. Yanagawa, M., Hiroshima, M., Togashi, Y., Abe, M., Yamashita, T., Shichida, Y., Murata, M., Ueda, M., and Sako, Y.:
  "Single-molecule diffusion-based estimation of ligand effects on G protein-coupled receptors"
  Sci. Signal. 11(548), eaao1917 (2018).
• 3. Hiroshima, M., Pack, C.-G., Kaizu, K., Takahashi, K., Ueda, M., and Sako, Y.:
  "Transient acceleration of epidermal growth factor receptor dynamics produces higher-order signaling clusters"
  J. Mol. Biol. 430(9), 1386-1401 (2018).
• 4. Maeda, R., Sato, T., Okamoto, K., Yanagawa, M., and Sako, Y.:
  "Lipid-protein interplay in dimerization of juxtamembrane domains of epidermal growth factor receptor"
  Biophys. J. 114(4), 893-903 (2018).
• 5. Nakamura, Y., Umeki, N., Abe, M., and Sako, Y.:
  "Mutation-specific mechanisms of hyperactivation of Noonan syndrome SOS molecules detected with single-molecule imaging in living cells"
  Sci. Rep. 7(1), 14153 (2017).
• 6. Arata, Y., Hiroshima, M., Pack, C.-G., Ramanujam, R., Motegi, F., Nakazato, K., Wiseman, P. W., Sawa, H., Kobayashi, T. J., Brandão, H. B., Shibata, T., and Sako, Y.:
  "Cortical polarity of the RING protein PAR-2 is maintained by exchange rate kinetics at the cortical-cytoplasm boundary"
  Cell Rep. 16(8), 2156-2168 (2016).
• 7. Takanezawa, S., Morita, S.-i., Ozaki, Y., and Sako, Y.:
  "Raman spectral dynamics of single cells in the early stages of growth factor stimulation"
  Biophys. J. 108(9), 2148-2157 (2015).
• 8. Mouri, K., and Sako, Y.:
  "Optimality conditions for cell-fate heterogeneity that maximize the effects of growth factors in PC12 cells"
  PLoS Comp. Biol. 9(11), e1003320 (2013).
• 9. Hiroshima, M., Saeki, Y., Okada-Hatakeyama, M., and Sako, Y.:
  "Dynamically varying interactions between heregulin and ErbB proteins detected by single-molecule analysis in living cells"
  Proc. Natl. Acad. Sci. USA. 109(35), 13984-13989 (2012).
• 10. Okamoto, K., and Sako, Y.:
  "Variational Bayes analysis of a photon-based hidden Markov model for single-molecule FRET trajectories"
  Biophys. J. 103(6), 1315-1324 (2012).

Recent Research Results

• 

  Nov. 30, 2018
  Movement patterns of receptors can indicate their activation status

• 

  Jul. 11, 2016
  Learning from the mussel, scientists create a biologically active titanium surface

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