Chief Scientist Laboratories Molecular Synthesis and Function Laboratory

Chief Scientist: Takuya Hashimoto (Ph.D.)

Japanese Page

Research Summary

Our research consists of three steps: designing and synthesizing new functional molecules, understanding their properties, and maximizing their functions. Our research targets include molecules ranging from small molecules with molecular weights of several hundred to polymers with molecular weights of several tens of thousands and biomolecules, and we are working on a wide range of functions, including reaction substrates, catalysts, molecular probes, and organic materials. The uniqueness of our research lies in our ability to "create new molecules" that no one has ever created before, and we aim to contribute to the development of the fields of materials science and life science involving molecules by creating a virtuous cycle of research from molecular design and synthesis to the development of highly functional molecules.

Main Research Fields

Chemistry

Related Research Fields

Synthetic organic chemistry
Organic materials science
Chemical biology

Keywords

Catalyst design
Selective synthesis
Molecular functional material
Chemical probe

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

1. *Oe, Y., Yoshida, R., Tanaka, A., Adachi, A., Ishibashi, Y., Okazoe, T., Aikawa, K., Hashimoto, T.
"An N-Fluorinated Imide for Practical Catalytic Imidations"
J. Am. Chem. Soc. 144, 2107-2113 (2022).
2. *Wata, C., Hashimoto, T.
"Organoiodine-Catalyzed Enantioselective Intermolecular Oxyamination of Alkenes"
J. Am. Chem. Soc. 143, 1745-1751 (2021).
3. *Hashimoto, T., Shimazaki, Y., Omatsu, Y., Maruoka, K.
"Indanol-Based Chiral Organoiodine Catalysts for Enantioselective Hydrative Dearomatization"
Angew. Chem. Int. Ed. 57, 7200-7204 (2018).
4. *Kawamata, Y., Hashimoto, T., Maruoka, K.
"A Chiral Electrophilic Selenium Catalyst for Highly Enantioselective Oxidative Cyclization"
J. Am. Chem. Soc. 138, 5206-5209 (2016).
5. *Hashimoto, T., Takino, K., Hato, K., Maruoka, K.
"A Bulky Thiyl-Radical Catalyst for the 3+2 Cyclization of N-Tosyl Vinylaziridines and Alkenes"
Angew. Chem. Int. Ed. 55, 8081-8085 (2016).
6. *Hashimoto, T., Nakatsu, H., Maruoka, K.
"Catalytic Asymmetric Diels-Alder Reaction of Quinone Imine Ketals: A Site-Divergent Approach"
Angew. Chem. Int. Ed. 54, 4617-4621 (2015).
7. *Hashimoto, T., Galvez, A. O., Maruoka, K.
"Boronic Acid-Catalyzed, Highly Enantioselective Aza-Michael Additions of Hydroxamic Acid to Quinone Imine Ketals"
J. Am. Chem. Soc. 137, 16016-16019 (2015).
8. *Hashimoto, T., Kawamata, Y., Maruoka, K.
"An organic thiyl radical catalyst for enantioselective cyclization"
Nature Chem. 6, 702-705 (2014).
9. *Hashimoto, T., Takiguchi, Y., Maruoka, K.
"Catalytic Asymmetric Three-Component 1,3-Dipolar Cycloaddition of Aldehydes, Hydrazides, and Alkynes
J. Am. Chem. Soc. 135, 11473-11476 (2013).
10. *Hashimoto, T., Sakata, K., Tamakuni, F., Dutton, M. J., Maruoka, K.
"Phase-transfer-catalysed asymmetric synthesis of tetrasubstituted allenes"
Nature Chem. 5, 240-244 (2013).

Annual research report

Lab Members

Principal investigator

Takuya Hashimoto: Chief Scientist

Contact Information

N306 Chemistry and Materials Physics Building
2-1 Hirosawa, Wako, Saitama 351-0198, Japan
Email: takuya.hashimoto [at] riken.jp