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Chief Scientist Laboratories RNA Systems Biochemistry Laboratory

Chief Scientist: Shintaro Iwasaki (Ph.D.)

Research Summary

Shintaro  Iwasaki(Ph.D.)

“The central dogma of molecular biology”, which represents information flow from DNA to RNA to protein, has been most basic principle in life. Recent quantitative and comprehensive analysis revealed that amount of RNA could not simply correlate with protein abundance in cells, suggesting that “translation control” significantly contributes to gene expression in more general than as we previously expected. Our laboratory tackles the unknown mechanism of translation control, by the combination of next-generation deep sequencing and classical biochemistry.

Main Research Fields

  • Biology

Related Research Fields

  • Biological Sciences
  • Life science
  • Genome science

Keywords

  • translation
  • RNA
  • Inhibitors

Selected Publications

  • 1.Chhipi Shrestha JK, Schneider-Poetsch T, Suzuki T, Mito M, Khan K, Dohmae N, Iwasaki S*, and Yoshida M*.:
    "Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns."
    Cell Chem Biol. S2451-9456(21)00355-X. (2021) DOI: 10.1016/j.chembiol.2021.07.015
  • 2.Makino S, Kawamata T, Iwasaki S*, and Ohsumi Y*.:
    "Selectivity of mRNA degradation by autophagy."
    Nat Commun. 12(1):2316. (2021). DOI: 10.1038/s41467-021-22574-6
  • 3.Yoshimoto R, Chhipi Shrestha JK, Schneider-Poetsch T, Furuno M, Burroughs MA, Noma S, Suzuki H, Hayashizaki Y, Mayeda A, Nakagawa S, Kaida D, Iwasaki S*, and Yoshida M*.:
    "Spliceostatin A interaction with SF3B1 limits U1 snRNP availability and causes premature cleavage and polyadenylation."
    Cell Chem Biol. S2451-9456(21)00111-2. (2021) DOI: 10.1016/j.chembiol.2021.03.002
  • 4.Chen M, Asanuma M#, Takahashi M#, Shichino Y, Mito M, Fujiwara K, Saito H, Floor SN, Ingolia NT, Sodeoka M, Dodo K, Ito T, and Iwasaki S*. (#: equal contribution).:
    "Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A."
    Cell Chem Biol. 28(4):475-486.e8. (2021) DOI: 10.1016/j.chembiol.2020.11.008
  • 5.Han P, Shichino Y, Schneider-Poetsch T, Mito M, Hashimoto S, Udagawa T, Kohno K, Yoshida M, Mishima Y, Inada T, and Iwasaki S*.:
    "Genome-wide survey of ribosome collision."
    Cell Rep. 31(5):107610. (2020) DOI: 10.1016/j.celrep.2020.107610
  • 6.Padrón A, Iwasaki S, and Ingolia NT..:
    "Proximity RNA labeling by APEX-Seq reveals the organization of translation initiation complexes and repressive RNA granules."
    Mol Cell. 75(4):875-887.e5. (2019) DOI: 10.1016/j.molcel.2019.07.030
  • 7.Iwasaki S*, Iwasaki W#, Takahashi M#, Sakamoto A, Watanabe C, Shichino Y, Floor SN, Fujiwara K, Mito M, Dodo K, Sodeoka M, Imataka H, Honma T, Fukuzawa K, Ito T*, and Ingolia NT*. (#: equal contribution).:
    "The translation inhibitor rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA."
    Mol Cell. 73(4):738-748.e9. (2019) DOI: 10.1016/j.molcel.2018.11.026
  • 8.Iwasaki S* and Ingolia NT*.:
    "The growing toolbox for protein synthesis studies."
    Trends Biochem Sci. 42(8):612-624. (2017) DOI: 10.1016/j.tibs.2017.05.004
  • 9.Iwasaki S, Floor SN, and Ingolia NT.:
    "Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor."
    Nature. 534(7608):558-61. (2016) DOI: 10.1038/nature17978
  • 10.Iwasaki S#, Sasaki MH#, Sakaguchi Y, Suzuki T, Tadakuma H, and Tomari Y. (#: equal contribution).:
    "Defining fundamental steps in the assembly of the Drosophila RNAi enzyme complex."
    Nature. 521(7553):533-6. (2015) DOI: 10.1038/nature14254

Recent Research Results

Annual research report

Related Links

Lab Members

Principal investigator

Shintaro Iwasaki
Chief Scientist

Core members

Eriko Matsuura
Research Scientist
Yuichi Shichino
Special Postdoctoral Researcher
Antonios Apostolopoulos
International Program Associate
Peixun Han
International Program Associate
Hironori Saito
Student Trainee
Taisei Wakigawa
Student Trainee
Shiho Makino
Research Fellow
Mari Mito
Technical Staff I
Rie Yokoyama
Special Temporary Employee

Contact Information

S205 Bioscience Bldg,
2-1 Hirosawa,
Wako, Saitama
351-0198, Japan
Email: shintaro.iwasaki [at] riken.jp

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