Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1. Saito H, Handa Y, Chen M, Schneider-Poetsch T, Shichino Y, Takahashi M, Romo D, Yoshida M, Fürstner A, Ito T, Fukuzawa K, and Iwasaki S^#.
  "DMDA-PatA mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs."
  Nat Commun. 15(1):7418 (2024) DOI: 10.1038/s41467-024-51635-9
• 2. Tomuro K^#, Mito M^#, Toh H, Kawamoto N, Miyake T, Chow SYA, Doi M, Ikeuchi Y, Shichino Y^#, and Iwasaki S^#.
  "Calibrated ribosome profiling assesses the dynamics of ribosomal flux on transcripts."
  Nat Commun. 15(1):7061 (2024) DOI: 10.1038/s41467-024-51258-0
• 3. Shichino Y^#, Yamaguchi T, Kashiwagi K, Mito M, Takahashi M, Ito T, Ingolia NT, Kuba K, and Iwasaki S^#.
  "eIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition."
  Nat Struct Mol Biol. Online ahead of print. (2024) DOI: 10.1038/s41594-024-01321-7
• 4. Apostolopoulos A, Kawamoto N, Chow SYA, Tsuiji H, Ikeuchi Y, Shichino Y^#, and Iwasaki S^#.
  "dCas13-mediated translational repression for accurate gene silencing in mammalian cells."
  Nat Commun. 15(1):2205 (2024) DOI: 10.1038/s41467-024-46412-7
• 5. Tanaka M^#, Yokoyama T^#, Saito H^#, Nishimoto M, Tsuda K, Sotta N, Shigematsu H, Shirouzu M, Iwasaki S^#, Ito T^#, and Fujiwara T^#.
  "Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1."
  Nat Chem Biol. 20(5):605–614 (2024) DOI: 10.1038/s41589-023-01513-0
• 6. Kashiwagi K^#, Shichino Y^#, Osaki T^#, Sakamoto A, Nishimoto M, Takahashi M, Mito M, Weber F, Ikeuchi Y^#, Iwasaki S^#, and Ito T^#.
  "eIF2B-capturing viral protein NSs suppresses the integrated stress response."
  Nat Commun. 12(1):7102. (2021) DOI: 10.1038/s41467-021-27337-x
• 7. Chen M, Asanuma M^#, Takahashi M^#, Shichino Y, Mito M, Fujiwara K, Saito H, Floor SN, Ingolia NT, Sodeoka M, Dodo K, Ito T, and Iwasaki S^#.
  "Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A."
  Cell Chem Biol. 28(4):475-486.e8. (2021) DOI: 10.1016/j.chembiol.2020.11.008
• 8. Han P, Shichino Y, Schneider-Poetsch T, Mito M, Hashimoto S, Udagawa T, Kohno K, Yoshida M, Mishima Y, Inada T, and Iwasaki S^#.
  "Genome-wide survey of ribosome collision."
  Cell Rep. 31(5):107610. (2020) DOI: 10.1016/j.celrep.2020.107610
• 9. Iwasaki S^#, Iwasaki W^#, Takahashi M^#, Sakamoto A, Watanabe C, Shichino Y, Floor SN, Fujiwara K, Mito M, Dodo K, Sodeoka M, Imataka H, Honma T, Fukuzawa K, Ito T^#, and Ingolia NT^#.
  "The translation inhibitor rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA."
  Mol Cell. 73(4):738-748.e9. (2019) DOI: 10.1016/j.molcel.2018.11.026
• 10. *Iwasaki S, Floor SN, and Ingolia NT^#.
  "Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor."
  Nature. 534(7608):558-61. (2016) DOI: 10.1038/nature17978

Recent Research Results

• 

  Jul. 11, 2024
  Silencing certain genes while still allowing others to talk

• 

  Jun. 1, 2023
  How a fungus sidesteps a plant’s defense mechanism

• 

  Mar. 8, 2019
  Natural plant defense could lead to new personalized cancer therapy

• 

  Jun. 19, 2018
  Blue gene regulation helps plants respond properly to light

Annual research report

Related Links

Lab Members

Contact Information