Research Summary

Selected Publications

• 1. Kashiwagi K^#, Shichino Y^#, Osaki T^#, Sakamoto A, Nishimoto M, Takahashi M, Mito M, Weber F, Ikeuchi Y^*, Iwasaki S^*, and Ito T^*. (#: equal contribution)
  "eIF2B-capturing viral protein NSs suppresses the integrated stress response."
  Nat Commun. 12(1):7102. (2021) DOI: 10.1038/s41467-021-27337-x
• 2. Chhipi Shrestha JK, Schneider-Poetsch T, Suzuki T, Mito M, Khan K, Dohmae N, Iwasaki S^*, and Yoshida M^*.
  "Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns."
  Cell Chem Biol. 29(2):259-275.e10. (2022) DOI: 10.1016/j.chembiol.2021.07.015
• 3. Makino S, Kawamata T, Iwasaki S^*, and Ohsumi Y^*.
  "Selectivity of mRNA degradation by autophagy."
  Nat Commun. 12(1):2316. (2021). DOI: 10.1038/s41467-021-22574-6
• 4. Yoshimoto R, Chhipi Shrestha JK, Schneider-Poetsch T, Furuno M, Burroughs MA, Noma S, Suzuki H, Hayashizaki Y, Mayeda A, Nakagawa S, Kaida D, Iwasaki S^*, and Yoshida M^*.
  "Spliceostatin A interaction with SF3B1 limits U1 snRNP availability and causes premature cleavage and polyadenylation."
  Cell Chem Biol. 28(9):1356-1365.e4. (2021) DOI: 10.1016/j.chembiol.2021.03.002
• 5. Chen M, Asanuma M^#, Takahashi M^#, Shichino Y, Mito M, Fujiwara K, Saito H, Floor SN, Ingolia NT, Sodeoka M, Dodo K, Ito T, and Iwasaki S^*. (#: equal contribution)
  "Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A."
  Cell Chem Biol. 28(4):475-486.e8. (2021) DOI: 10.1016/j.chembiol.2020.11.008
• 6. Han P, Shichino Y, Schneider-Poetsch T, Mito M, Hashimoto S, Udagawa T, Kohno K, Yoshida M, Mishima Y, Inada T, and Iwasaki S^*.
  "Genome-wide survey of ribosome collision."
  Cell Rep. 31(5):107610. (2020) DOI: 10.1016/j.celrep.2020.107610
• 7. Padrón A, Iwasaki S, and Ingolia NT.
  "Proximity RNA labeling by APEX-Seq reveals the organization of translation initiation complexes and repressive RNA granules."
  Mol Cell. 75(4):875-887.e5. (2019) DOI: 10.1016/j.molcel.2019.07.030
• 8. Iwasaki S^*, Iwasaki W^#, Takahashi M^#, Sakamoto A, Watanabe C, Shichino Y, Floor SN, Fujiwara K, Mito M, Dodo K, Sodeoka M, Imataka H, Honma T, Fukuzawa K, Ito T^*, and Ingolia NT^*. (#: equal contribution)
  "The translation inhibitor rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA."
  Mol Cell. 73(4):738-748.e9. (2019) DOI: 10.1016/j.molcel.2018.11.026
• 9. Iwasaki S, Floor SN, and Ingolia NT.
  "Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor."
  Nature. 534(7608):558-61. (2016) DOI: 10.1038/nature17978
• 10. Iwasaki S^#, Sasaki MH^#, Sakaguchi Y, Suzuki T, Tadakuma H, and Tomari Y. (#: equal contribution)
  "Defining fundamental steps in the assembly of the Drosophila RNAi enzyme complex."
  Nature. 521(7553):533-6. (2015) DOI: 10.1038/nature14254

Recent Research Results

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  Mar. 8, 2019
  Natural plant defense could lead to new personalized cancer therapy

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  Jun. 19, 2018
  Blue gene regulation helps plants respond properly to light

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