Research Summary

Selected Publications

• 1.Padron A., Iwasaki S., and Ingolia NT.:
  "Proximity RNA labeling by APEX-Seq reveals the organization of translation initiation complexes and repressive RNA granules"
  Mol. Cell. 75(4):875-887. (2019)
• 2.Iwasaki S., Iwasaki W., Takahashi M. (equal contribution), Sakamoto A., Watanabe C., Shichino Y., Floor SN., Fujiwara K., Mito M., Dodo K., Sodeoka M., Imataka H., Honma T., Fukuzawa K., Ito T., and Ingolia NT.:
  "The translation inhibitor Rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA"
  Mol. Cell. 73(4):738-748. (2019)
• 3.AkichikaS., Hirano S (equal contribution)., Shichino Y., Suzuki T., Nishimasu H., Ishitani R., Sugita A., Hirose Y., Iwasaki S., Nureki O., and Suzuki T.:
  "Cap-specific terminal N⁶-methylation of RNA by an RNA polymerase II?associated methyltransferase"
  Science. 11;363(6423) (2019)
• 4.Kurihara Y., Makita Y., Kawashima M., Fujita T., Iwasaki S., and Matsui M.:
  "Transcripts from downstream alternative transcription start sites evade uORF-mediated inhibition of gene expression in Arabidopsis
  Proc Natl Acad Sci U S A. 115(30):7831-7836 (2018)
• 5.Iwasaki S. and Ingolia NT.:
  "The Growing Toolbox for Protein Synthesis Studies"
  Trends Biochem Sci. 42(8):612-624 (2017)
• 6.Iwasaki S., Floor SN., and Ingolia NT.:
  "Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor"
  Nature 534(7608), 558-61 (2016)
• 7.Werner A., Iwasaki S., Teerikorpi N., Fedrigo I., Ingolia NT., and Rape M.:
  "Cell fate determination by ubiquitin-dependent regulation of ribosome function"
  Nature 525(7570), 523-7 (2015)
• 8.Iwasaki S., Sasaki MH. (equal contribution), Sakaguchi Y., Suzuki T., Tadakuma H., and Tomari Y.:
  "Defining fundamental steps in the assembly of Drosophila RNAi enzyme comple"
  Nature 521(7553), 533-6 (2015)
• 9.Iwasaki S., Kobayashi M. (equal contribution), Yoda M., Sakaguchi Y., Katsuma S., Suzuki T., and Tomari Y.:
  "Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes"
  Mol. Cell. 39(2), 292-9 (2010)
• 10.Iwasaki S., Kawamata T., and Tomari Y.:
  "Drosophila Argonaute1 and Argonaute2 employ distinct mechanisms for translational repression"
  Mol Cell. 34(1), 58-67 (2009)

Recent Research Results

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  Mar. 8, 2019
  Natural plant defense could lead to new personalized cancer therapy

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  Jun. 19, 2018
  Blue gene regulation helps plants respond properly to light

Annual research report

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