Research Summary

Selected Publications

• 1. Zheng Y., Sakai K., Takagi H., Watanabe K., Sato-Shiozaki Y., Misumi Y., Kurisu G., Nogawa T., Takita R., Takahashi S.:
  "Iron-sulphur protein catalysed [4+2] cycloadditions in natural product biosynthesis."
  Nat. Commun., 15(1): 5779 (2024).
• 2. Zheng Y., Morita N., Takagi H., Shiozaki-Sato Y., Jun Ishikawa, Shin-ya K., and Takahashi S.:
  "Alanyl-tRNA synthetase-like enzymes catalyzed aminoacylation in the biosynthesis of nucleoside sulfamate ascamycin."
  ACS Catal. 14: 3533−3542 (2024).
• 3. Sakai K., Futamura Y., Nogawa T., Zhao Y., Koshino H., Osada H., and Takahashi S.:
  "Production of kinanthraquinone D with anti-malarial activity by heterologous gene expression and biotransformation in Streptomyces lividans TK23."
  J. Nat. Prod., 87(4): 855–860 (2024).
• 4. Abdelhakim I.A., Futamura Y., Asami Y., Hanaki H., Kito N., Masuda S., Shibata A., Shirasu K., Osada H., Ishikawa J., and Takahashi S.:
  "Expression of Syo_1.56 SARP Regulator Unveils Unprecedented Elasnin Derivatives with Potent Antibacterial Activity."
  J. Nat. Prod., 87(5): 1459–1470 (2024).
• 5. Hashimoto T., Suenaga H., Amagai K., Hashimoto J., Kozone I., Takahashi S., Kazuo Shin-ya K.:
  "In vitro module editing of NRPS enables production of highly potent Gq-signaling inhibitor FR900359 derived from unculturable plant symbiont."
  Angew. Chem. Int. Ed., 63: e202317805 (2024).
• 6. Vo N.N.Q., Nomura Y., Kinugasa K., Takagi H., and Takahashi S.:
  "Identification and characterization of a bifunctional drimenol synthase of bacterial origin from Aquimarina spongiae."
  ACS Chem. Biol., 17: 1226−1238 (2022).
• 7. Fujiyama K., Kato N., Re S., Kinugasa K., Watanabe K., Takita R., Nogawa T., Hino T., Osada H., Sugita Y., Takahashi S., and Nagano S.:
  "Molecular basis for two stereoselective Diels-Alderases that produce decalin skeletons."
  Angew. Chem. Int. Ed. Engl. 60: 22401-22410 (2021).
• 8. Panthee S., Kito N., Hayashi T., Shimizu T, Ishikawa J., Osada H., and Takahashi S.:
  "β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593."
  Sci. Rep. 10(1): 10230 (2020).
• 9. Kanoh N., Kawamata A., Suzuki K., Takahashi Y., Miyazawa T., Nakamura T., Moriya T., Hirano H., Osada H., Iwabuchi Y., and Takahashi S.:
  "An integrated screening system for the selection of exemplary substrates for natural and engineered cytochrome P450s."
  Sci. Rep. 9(1): 18023 (2019).
• 10. Kato N., Nogawa T., Takita R., Kinugasa K., Kanai M., Uchiyama M., Osada H., and Takahashi S.:
  "Control of the stereochemical course of [4+2] cycloaddition during trans-decalin formation by Fsa2-family enzymes."
  Angew. Chem. Int. Ed., 57: 9754-9758 (2018).

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