Research Summary

Selected Publications

Papers with an asterisk(*) are based on research conducted outside of RIKEN.

• 1. *Vaidya, AS., Peterson, F.C., Eckhardt, J., Xing, Z., Park, S.Y., Dejonghe, W., Takeuchi, J., Pri-Tal, O., Faria, J., Elzinga, D., Volkman, B.F., Todoroki, Y., Mosquna, A., Okamoto, M., Cutler, S.R.:
  "Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo."
  Proc. Natl. Acad. Sci. USA. 118: e2108281118 (2021)
• 2. *Takeuchi, J., Fukui, K., Seo, Y., Takaoka, Y., Okamoto, M.:
  "Ligand–receptor interactions in plant hormone signaling.
  Plant Journal, 105, 290–306 (2021)
• 3. *Vaidya, A.S., Helander, J.D.M., Peterson, F.C., Elzinga, D., Dejonghe, W., Kaundal, A., Park, S.Y., Xing, Z., Mega, R., Takeuchi, J. Khanderahoo B. Bishay S. Volkman BF. Todoroki Y. Okamoto M. Cutler SR.:
  "Dynamic control of plant water use using designed ABA receptor agonists."
  Science 366: 6464 (2019)
• 4. *Fujioka, H., Samejima, H., Suzuki, H., Mizutani, M., Okamoto, M., Sugimoto, Y.:
  "Aberrant protein phosphatase 2C leads to abscisic acid insensitivity and high transpiration in parasitic Striga."
  Nature Plants 5: 258-262 (2019)
• 5. Mega, R., Abe, F., Kim, J.K., Tsuboi, Y., Tanaka, K., Kobayashi, H., Sakata, Y., Ha:nada, K., Tsujimoto, H., Kikuchi, J., Cutler, S.R., Okamoto, M.
  "Tuning water use efficiency and drought tolerance using abscisic acid receptors."
  Nature Plants 5: 153-159 (2019)
• 6. Nakaminami, K., Okamoto, M., Higuchi-Takeuchi, M., Yoshizumi, T., Yamaguchi, Y., Fukao, Y., Shimizu, M., Ohashi, C., Tanaka, M., Matsui, M., Shinozaki, K., Seki, M., Hanada, K.:
  "AtPep3 is a hormone-like peptide that plays a role in the salinity stress tolerance of plants."
  Proc. Natl. Acad. Sci. USA. 115: 5810-5815 (2018)
• 7. *Takeuchi, J., Mimura, N., Okamoto, M., Yajima, S., Sue, M., Akiyama, T., Monda, K., Iba, K., Ohnishi, T., Todoroki, Y.:
  "Structure-Based Chemical Design of Abscisic Acid Antagonists That Block PYL-PP2C Receptor Interactions."
  ACS Chemical Biology 13: 1313-1321 (2018)
• 8. *Yan, D., Easwaran, V., Chau, V., Okamoto, M., Ierullo, M., Kimura, M., Endo, A., Yano, R., Pasha, A., Gong, Y., Bi, Y.M., Provart, N., Guttman, D., Krapp, A., Rothstein, S.J., Nambara, E.:
  "NIN-like protein 8 is a master regulator of nitrate-promoted seed germination in Arabidopsis."
  Nature Communications 7:13179 (2016)
• 9. Takeuchi, J., Okamoto, M., Akiyama, T., Muto, T., Yamaji, S., Sue, M., Seo, M., Kanno, Y., Kamo, T., Endo, A., Nambara, E., Hirai, N., Ohnishi, T., Cutler, S.R., Todoroki, Y.:
  "Designed abscisic acid analogues as antagonists of PYL-PP2C receptor interactions."
  Nature Chemical Biology 10:477-482 (2014)
• 10. *Okamoto, M., Peterson, F.C., Defries, A., Park, S.Y., Endo, A., Nambara, E., Volkman. B.F., Cutler, S.R.:
  "Activation of dimeric ABA receptor elicits guard cell closure, ABA-regulated gene expression and drought tolerance."
  Proc. Natl. Acad. Sci. USA 110: 12132-7 (2013)

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